11 May 2020
Scientists and clinicians based at the Schools of Life Sciences and Medicine at the University have been awarded funding from the Chief Scientist Office that will help identify those most vulnerable to severe symptoms of coronavirus. The team led by Professor Doreen Cantrell, a Professor of Cellular Immunology and Professor James Chalmers, a leading respiratory disease physician at Ninewells, has been awarded £294,000 to help identify patients experiencing symptoms of Covid-19 whose condition could significantly worsen.
01 May 2020
Scientists at the University of Dundee and the EMBL’s European Bioinformatics Institute (EMBL-EBI) have published online some of the largest and highest resolution images yet recorded of the SARS-CoV-2 virus, the cause of the Covid-19 pandemic. The images were collected by a consortium of researchers from the Hubrecht Institute in Utrecht, Erasmus MC University Medical Center Rotterdam, and Maastricht University in the Netherlands.
01 May 2020
Whole genome sequencing gives new insights into cancer genomics Summary By analysing genomic data from worms, scientists detailed how mutations are caused by a combination of DNA damage and inaccurate repair This shows that a single DNA-damaging agent can generate a multitude of mutational signatures depending on the repair mechanisms involved in fixing the original damage The research could help pinpoint the causes of mutations found in the genomes of cancer patients and healthy individuals
28 Apr 2020
Researchers in the School have discovered a new neurodevelopmental disease caused by genetic mutations and helped explain why patients with these mutations suffer this condition. Around 1% of the global population are affected by intellectual disability, a condition characterised by significant limitations in both intellectual function and in adaptive behaviour. It was known that a molecule called GlcNAc was found on proteins related to intellectual disability, but its exact role in this disease remained unclear.
23 Apr 2020
A University of Dundee researcher has been awarded £1.6 million in funding from UK Research and Innovation (UKRI) to develop machine learning tools for the life sciences. Machine learning has rapidly transformed many aspects of our daily lives in the last decade. It is also increasingly playing a vital role in analysing biomedical data. However, using these techniques to answer fundamental, mechanistic questions about biological processes remains challenging.
13 Mar 2020
New research by Greg Findlay’s group in the MRC-PPU has identified a signalling system that controls embryonic stem cell development, which has implications for understanding how tissues form within the mammalian embryo. The paper, by Rosalia Fernandez-Alonso and Francisco Bustos, post-doctoral investigators in Greg’s lab, uncovers a new role for the EPH-Ephrin system in regulating stem cell differentiation.
04 Mar 2020
This week forty researchers completed a two-day workshop in Cryo Electron Microscopy (EM) held in the School. Cryo EM makes it possible to see the biological molecules that underpin life in atomic detail. Participants from Dundee and St Andrews benefited from lectures and practical workshops given by experts from across the UK including:
22 Jan 2020
Professors Vicky Cowling and Tomo Tanaka were given Investigator Awards from Wellcome in the recent funding round. Vicky’s award of £1.3M will allow her to take her expertise on mRNA cap regulation in a new direction while Tomo’s award of ~£1.5M will allow him to continue to build new knowledge on the process of cell division. This will fund their programmes of research for 5 years.
21 Jan 2020
Researchers in the School of Life Sciences at the University of Dundee have helped to uncover and understand the genome of a vitally important orphan crop, called water yam.
16 Jan 2020
A study published this week in the journal eLife, by a team at University of Dundee's School of Life Sciences uses a new approach to reveal the complexity and modifications of RNA that are essential to genetic control. They passed RNA through pores developed by Oxford Nanopore Technology to reveal directly the sequence of 1000s of RNA molecules.