15 Jan 2018
Mitophagy is the autophagic removal of damaged or impaired mitochondria. A new study published in Cell Metabolism from Ian Ganley and colleagues, shows for the first time that dopaminergic neurons within the substantia nigra undergo a striking amount of mitophagy. This is important because it is this population of neurons that degenerate in Parkinson’s Disease (PD) and impaired mitophagy has been implicated in this pathology.
13 Nov 2017
Professor Karim Labib will delve into the science behind the fabric of our very existence at the next Café Science event. Professor Labib from the MRCPPU will be talking about DNA and how it passes from one generation to the next. At the event, on Monday 13 November at Avery & Co, he will explain what this process can tell us about the evolution of life.
31 Oct 2017
Adrien Rousseau has opened a new laboratory in the MRC PPU to investigate signalling pathways controlling proteasome homeostasis. A major goal of Adrien’s laboratory will be to unravel the crosstalk between protein phosphorylation and ubiquitin proteasomal degradation pathways. The aim is to better understand how cells prevent accumulation of unfolded, misfolded, or damaged proteins that is deleterious and an underlying cause of various age-related diseases, including cancers and neurodegenerative disorders.
24 Oct 2017
John Rouse, together with researchers Detlev Schindler at the University of Wuerzburg, and Minoru Takata at the University of Kyoto, have won the Fanconi Anemia Research Fund 2017 Discovery Award for the discovery and characterization of the Fanconi anemia gene FANCW. Commenting on the award John said: “I’m delighted that our work on FANCW should be recognized by the Fanconi Anemia Research Fund.
16 Oct 2017
Tom McWilliams, a postdoc at the MRC PPU has been awarded a prestigious Academy of Finland Research Fellowship. The Academy of Finland is the pre-eminent scientific funding body in Finland, and their highly competitive research fellowship scheme aims to attract and support young investigators with outstanding potential.
10 Oct 2017
Researchers in the laboratory of Professor Alessio Ciulli have designed a small molecule that tricks a particular E3 ubiquitin ligase protein to destroy another of its kind. E3 ligases act like ‘molecular assassins’ in cells as they naturally tag unwanted proteins for cellular degradation. There are believed to be over 600 E3 ligases in the human cell and many are involved in human diseases, providing many attractive targets for drug discovery.
05 Oct 2017
Scientists at the School have identified the structure of a key enzyme that protects the brain against Parkinson’s disease. The result of a decade of work, the research team said that solving the 3D structure and inner workings of the PINK1 enzyme represented a major breakthrough.
26 Sep 2017
This year, our traditional poster session for PhD students entering into their third year formed part of a Dundee-Tokyo Postgraduate Student Research Symposium, including a group of PhD students and academics from University of Tokyo.
18 Sep 2017
Life Sciences researcher Professor Karim Labib has been awarded £2million to explore the role that one of the most fundamental processes in cell biology plays in cancer. Professor Labib will receive the grant from Cancer Research UK to study mechanisms that preserve genome integrity during the final stages of chromosome replication in animal cells.
18 Jul 2017
Dr Miratul Muqit has been awarded the prestigious Francis Crick Medal and Lecture by the Royal Society in recognition of discoveries that have led to better understanding of the causes of Parkinson’s disease.