02 Jul 2019
Two PhD students in the School have been selected to join Europe’s finest University students in creative and intellectual collaboration at Roche Continents 2019. The highly prestigious Roche Continents - a full week of interdisciplinary challenges and inspiration – selects only 100 students from the sciences and arts at European Universities to attend. Tom Snelling from Philip Cohen's Lab (MRC-PPU) and Margarita Kalamara from Nicola Stanley-Wall’s Lab (Molecular Microbiology) are two of those who will take part in the week of activities in Salzburg in August.
21 Jun 2019
The University of Dundee has today awarded an Honorary Doctorate to Dr Samantha Budd Haeberlein who is Vice President of Late Stage Clinical Development at Biogen. Samantha is a distinguished graduate of Dundee having obtained a First Class Honours Degree in Biochemistry in 1994 and then completing a PhD in 1997 under the supervision of David Nicholls FRS on the bioenergetics of neurons. Since then Samantha has flourished in the pharmaceutical industry over the last 20 years and emerged as a global leader in developing effective therapies against Alzheimer’s disease.
18 Jun 2019
About 10 years ago, the discovery of the Linear Ubiquitin Assembly Complex (LUBAC) revolutionized our understanding of how the master transcription factor NF-kB was activated. LUBAC a complex of the three proteins, HOIP, HOIL-1 and Sharpin, produces unique “linear” ubiquitin chains in which ubiquitins are joined to each other by peptide bonds.
23 Apr 2019
Alan Prescott has been awarded third place in the annual British Society for Cell Biology (BSCB) image competition. His confocal image is of a cultured mouse embryo fibroblast from the mito-QC mouse. Mitochondria express both eGFP and mCherry but in lysosomes the eGFP, green fluorescence is quenched. Bright red dots are mitolysosomes. The nucleus is DAPI stained, blue. The image features in the Journal of Cell Biology publication from Ian Ganley's lab (McWilliams et al., (2016) JCB, 214(3).
19 Apr 2019
Latest research from Professor Kim Dale and collaborators has uncovered further knowledge into the developmental segmentation process which may also impact on our understanding of diseases such as cancer. This research was published this week in EMBO Reports.
15 Apr 2019
Hannah Tovell an Alessi lab PhD student working closely with the Ciulli lab has published an improved HaloPROTAC method to induce post–translational knockdown of endogenous proteins. This approach makes use of CRISPR/Cas9 genome editing technology to introduce a Halo tag onto the N or C terminus of any desired target protein that can then be targeted for degradation by a HaloPROTAC probe (see Figure).
22 Mar 2019
Last week, the School’s Annual Research Symposium was held at Crieff Hydro. The programme of talks and poster presentations covered the diverse research taking place in the School. Newly appointed Principal Investigators and Professors gave talks alongside more junior members of the School, who spoke as part of the SLS showcase sessions.
01 Feb 2019
Researchers from the Schools of Life Sciences and Medicine have been awarded a £275,000 grant from Diabetes UK. This inter-divisional and cross-School funding has been awarded to Professor Hari Hundal (Division of Cell Signalling & Immunology), Dr Ian Ganley (MRC Protein Phosphorylation and Ubiquitylation Unit) and Professor Rory McCrimmon (School of Medicine).
19 Nov 2018
Dr Greg Findlay from the Medical Research Council Protein Phosphorylation and Ubiquitylation Unit (MRC PPU) and an associate of the Division of Cell Development and Biology has been awarded tenure today.
07 Nov 2018
Scientists in the School have confirmed that a key cellular pathway that protects the brain from damage is disrupted in Parkinson’s patients, raising the possibility of new treatments for the disease. Parkinson’s is a disabling disorder of the brain for which there is no cure. Mutations in two genes called PINK1 and Parkin are associated with early-onset forms of Parkinson’s. Both encode distinct classes of enzymes that play a pivotal role in protecting the brain against stress.