12 Apr 2018
Dr Virdee and colleagues in the Medical Research Council Protein Phosphorylation and Ubiquitylation Unit (MRC PPU) have discovered a novel class of E3 ligase. The E3 ligase, MYCBP2, operates in a unique way, selectively transferring ubiquitin to non-lysine amino acids with selectivity for threonine. The ubiquitin is linked to the threonine amino acid via a chemically distinct ester linkage thereby uncovering an unanticipated area of cellular biology. The findings are published in Nature.
12 Apr 2018
Professor Sir Ian Wilmut – who led the team that created Dolly the sheep – has backed an initiative to tackle Parkinson’s disease, after being diagnosed with the condition.
04 Apr 2018
In a paper just published in Molecular Cell, Dominka Kwasna from Yogesh Kulathu’s group at the MRC PPU, in collaboration with Ian Gibbs-Seymour at the University of Oxford, reports the discovery of a completely new class of enzymes that is important for protecting the cell’s DNA from damage.
23 Mar 2018
Researchers from the University of Dundee and the Francis Crick Institute have made a significant discovery about a cellular pathway associated with developmental defects and a myriad of diseases ranging from alopecia to colorectal cancer.
19 Mar 2018
Last week, the School’s Annual Research Symposium was held at Crieff Hydro. The programme of talks and poster presentations covered the diverse research taking place in the School. Newly appointed Principal Investigators and Professors gave talks alongside more junior members of the School, who spoke as part of the SLS showcase sessions.
07 Mar 2018
A Parkinson’s patient who has lived with the disease for more than a decade has visited the University of Dundee to see how money he has raised will be used to research potential new treatments for the condition.
20 Feb 2018
Research from Professor Anton Gartner’s group in the Centre for Gene Expression and Regulation has provided new information on the mechanics of cell division. Published today in Nature Communications, the work shows the role of a particular protein in this process that may have implications in understanding some types of breast and ovarian cancer.
22 Jan 2018
Last week, at Review of the Year, Professor Julian Bow presented the annual School Prizes. The awards recognise excellence by members of the School in research and public engagement.
15 Jan 2018
Mitophagy is the autophagic removal of damaged or impaired mitochondria. A new study published in Cell Metabolism from Ian Ganley and colleagues, shows for the first time that dopaminergic neurons within the substantia nigra undergo a striking amount of mitophagy. This is important because it is this population of neurons that degenerate in Parkinson’s Disease (PD) and impaired mitophagy has been implicated in this pathology.
13 Nov 2017
Professor Karim Labib will delve into the science behind the fabric of our very existence at the next Café Science event. Professor Labib from the MRCPPU will be talking about DNA and how it passes from one generation to the next. At the event, on Monday 13 November at Avery & Co, he will explain what this process can tell us about the evolution of life.