23 Apr 2019
Alan Prescott has been awarded third place in the annual British Society for Cell Biology (BSCB) image competition. His confocal image is of a cultured mouse embryo fibroblast from the mito-QC mouse. Mitochondria express both eGFP and mCherry but in lysosomes the eGFP, green fluorescence is quenched. Bright red dots are mitolysosomes. The nucleus is DAPI stained, blue. The image features in the Journal of Cell Biology publication from Ian Ganley's lab (McWilliams et al., (2016) JCB, 214(3).
19 Apr 2019
Latest research from Professor Kim Dale and collaborators has uncovered further knowledge into the developmental segmentation process which may also impact on our understanding of diseases such as cancer. This research was published this week in EMBO Reports.
15 Apr 2019
Hannah Tovell an Alessi lab PhD student working closely with the Ciulli lab has published an improved HaloPROTAC method to induce post–translational knockdown of endogenous proteins. This approach makes use of CRISPR/Cas9 genome editing technology to introduce a Halo tag onto the N or C terminus of any desired target protein that can then be targeted for degradation by a HaloPROTAC probe (see Figure).
22 Mar 2019
Last week, the School’s Annual Research Symposium was held at Crieff Hydro. The programme of talks and poster presentations covered the diverse research taking place in the School. Newly appointed Principal Investigators and Professors gave talks alongside more junior members of the School, who spoke as part of the SLS showcase sessions.
01 Feb 2019
Researchers from the Schools of Life Sciences and Medicine have been awarded a £275,000 grant from Diabetes UK. This inter-divisional and cross-School funding has been awarded to Professor Hari Hundal (Division of Cell Signalling & Immunology), Dr Ian Ganley (MRC Protein Phosphorylation and Ubiquitylation Unit) and Professor Rory McCrimmon (School of Medicine).
19 Nov 2018
Dr Greg Findlay from the Medical Research Council Protein Phosphorylation and Ubiquitylation Unit (MRC PPU) and an associate of the Division of Cell Development and Biology has been awarded tenure today.
07 Nov 2018
Scientists in the School have confirmed that a key cellular pathway that protects the brain from damage is disrupted in Parkinson’s patients, raising the possibility of new treatments for the disease. Parkinson’s is a disabling disorder of the brain for which there is no cure. Mutations in two genes called PINK1 and Parkin are associated with early-onset forms of Parkinson’s. Both encode distinct classes of enzymes that play a pivotal role in protecting the brain against stress.
06 Nov 2018
PhD students from the MRC PPU took part in the Biotechnology YES 2018 entrepreneurial competition last week. Luke Fulcher (Sapkota lab), Lambert Montava Garriga (Ganley lab), Maria Zachari (Ganley lab) and Marianna Longo (Ganley lab) formed the team “AllerTek” which sought to combat the presence of food allergens in meals. The biotechnology YES competition allows PhD students from across the UK to compete against each other with their ideas in a “dragons den” style pitch to secure theoretical funding for their innovation.
05 Nov 2018
The success of a University of Dundee collaboration that has attracted almost £60 million of investment, helped develop dozens of drugs for clinical use and won the prestigious Queen’s Anniversary Award will be celebrated this week. Scientists, politicians and representatives of some of the world’s biggest pharmaceutical companies will come together to mark the 20th anniversary of the University of Dundee’s Division of Signal Transduction Therapy (DSTT).
25 Oct 2018
Yesterday, saw our annual poster session for our third year PhD students take place in the School. The event allows our students to present their research findings to attendees from across the School. The day was a great success with lots of insightful scientific conversations taking place.