Latest News for 07/2020
03 Feb 2020
University of Dundee researchers have shown how a natural product derived from a group of fungi that has inspired horror novels, movies and computer games works to switch on a protein known to affect cancer cells.
10 Jul 2019
Prof. Grahame Hardie and two of his co-workers, Diana Vara-Ciruelos and Fiona Russell, have published a review in the journal Open Biology with a title inspired by the classic novella by the Scottish author Robert Louis Stevenson. Their article discusses the controversial role in cancer of AMP-activated protein kinase (AMPK), which was first defined and named by Prof. Hardie at the University of Dundee in the late 1980s.
17 Apr 2019
Researchers from the Division of Cell Signalling and Immunology in the School have shown that a drug previously used to treat Type 2 diabetes could potentially be used to protect against cancer. A study carried out by Professors Grahame Hardie and Doreen Cantrell has shown that the drug phenformin protects mice against a type of cancer called T-cell lymphoma. It does this by switching on the protein AMPK, which was first defined by Professor Hardie in the 1980s. Subsequent research at Dundee showed a link between AMPK and cancer.
19 Jul 2017
A scientific collaboration between researchers in Scotland and China has uncovered a new kind of `energy sensor’ in our cells, changing our understanding of how the body monitors glucose levels and switches on the supply of alternative `fuels’. It is thought the research, published in the journal Nature, could have particular implications for diabetes, in which the level of glucose in the blood is abnormally high.
19 Apr 2017
School of Life Sciences scientists have won a hat-trick of funding awards from the Wellcome Trust that will see more than £6million invested in their research. Professors Doreen Cantrell, Mark Field and Grahame Hardie have been successful in winning grants from Wellcome.
05 Jul 2016
Research led by the University of Dundee has found that one of a new breed of drugs, which have been approved for treatment of Type 2 diabetes, may be particularly effective without the need to be used in combination with the existing drug, metformin.
05 Feb 2013
A review in Nature by Grahame Hardie of the Division of Cell Signalling and Immunology at CLS and Luke O’Neill (Trinity College Dublin) suggests that AMPK-activating drugs have both anti-cancer and anti-inflammatory properties.
23 Apr 2012
Grahame Hardie’s news story about aspirin’s potential for preventing cancer has gone global.
19 Apr 2012
New research carried out by Professor Grahame Hardie at the College of Life Sciences could lead to new uses for one of the world’s oldest medicines.
26 Mar 2012
Professor Grahame Hardie, of the Division of Cell Signalling and Immunology has been awarded a Wellcome Trust Senior Investigator Award for his research into 'Non-canonical pathways for regulation of AMPK'.