Latest News for 07/2020
12 May 2020
Launching today, Tuesday 12 May, the COVID-19 Protein Portal allows UK scientists to access protein reagents for critical research relating to SARS-CoV-2. Protein reagents are provided free of charge by a consortium of leading protein production laboratories, in an Open Science initiative led by Wellcome and UKRI.
30 Mar 2020
Scientists at the Universities of Dundee and Glasgow are combining their expertise to aid the global battle against coronavirus. The collaboration brings together world-leading researchers at Medical Research Council-funded units at both institutions to generate biological tools that will enable them to study the virus and identify ways of defeating it.
26 Mar 2020
A protocol for utilizing human peripheral blood neutrophils for research into the Parkinson’s disease associated LRRK2 kinase has been published. The collaborative work led by Esther Sammler, Clinical Programme Leader in the Medical Research Council Protein Phosphorylation and Ubiquitylation Unit in the School and Clinical Senior Lecturer & Honorary Consultant in the School of Medicine.
New collaboration will harness latest technology to uncover role of proteins in neurodegenerative...02 Mar 2020
A pioneering collaboration between the UK Dementia Research Institute (DRI) and the Medical Research Council’s Protein Phosphorylation and Ubiquitylation Unit (MRC PPU) will use the very latest advances in technology to study rare cell populations and the role of proteins in diseases such as Alzheimer’s and Parkinson’s.
31 Oct 2019
Researchers at the University of Dundee have made a discovery they believe has the potential to put the brakes on the ‘runaway train’ that is Parkinson’s disease. The team, based at the Medical Research Council Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU) in the School of Life Sciences, have discovered a new enzyme that inhibits the LRRK2 pathway. Mutations of the LRRK2 gene are the most common cause of genetic Parkinson’s.
29 Aug 2019
Hannah Tovell a PhD student in Dario Alessi lab working in collaboration with Claire Crafter (AstraZeneca) and Alessio Ciulli and Andrea Testa in his lab have elaborated a compound that we have termed SGK3-PROTAC1 that induces selective degradation of SGK3 protein kinase. Hannah was able to show that SGK3-PROTAC1 suppressed proliferation of ZR-75-1 and CAMA-1 cancer cell lines treated with a PI3K inhibitor (GDC0941) more effectively than could be achieved by a conventional SGK isoform inhibitor (14H), underscoring the benefit of the PROTAC approach.
15 Apr 2019
Hannah Tovell an Alessi lab PhD student working closely with the Ciulli lab has published an improved HaloPROTAC method to induce post–translational knockdown of endogenous proteins. This approach makes use of CRISPR/Cas9 genome editing technology to introduce a Halo tag onto the N or C terminus of any desired target protein that can then be targeted for degradation by a HaloPROTAC probe (see Figure).
05 Nov 2018
The success of a University of Dundee collaboration that has attracted almost £60 million of investment, helped develop dozens of drugs for clinical use and won the prestigious Queen’s Anniversary Award will be celebrated this week. Scientists, politicians and representatives of some of the world’s biggest pharmaceutical companies will come together to mark the 20th anniversary of the University of Dundee’s Division of Signal Transduction Therapy (DSTT).
07 May 2018
The Michael J. Fox Foundation for Parkinson’s Research (MJFF) has awarded MRC PPU Director Dario Alessi the 2018 MJFF Langston Award for “service and dedication to our shared goals of advancing Parkinson's understanding and therapeutic development”. For further information see here.
12 Apr 2018
Professor Sir Ian Wilmut – who led the team that created Dolly the sheep – has backed an initiative to tackle Parkinson’s disease, after being diagnosed with the condition.