MRC PPU DNA Sequencing and Services Established in 1998, we are a core DNA sequencing and fragment analysis facility based within the Medical Research Council Protein Phosphorylation and Ubiquitylation Unit (MRC PPU) in Dundee, Scotland. We are proud to be able to say that since our start we have continued to provide our services not only to local laboratories in Scotland but through the UK and internationally. Indeed we have hundreds of clients who rely on our services.
We provide a wide range of contract research products for DNA analysis and associated services and treat all clients and their samples with the strictest of confidentiality. We are also willing to discuss custom projects. Please contact us to discuss your individual requirements and how we might assist you.
International Centre for Kinase Profiling Protein kinases are the pharmaceutical industry's most important class of drug target. Nineteen protein kinase inhibitors have been approved for clinical use and over 150 more are undergoing clinical trials of which about 25 are in Phase III. A major challenge in this area is to develop a drug that selectively suppresses the activity of one, or at most a few, of the 500 protein kinases encoded by the human genome. The MRC Protein Phosphorylation Unit at Dundee pioneered analysis of the selectivity of protein kinase inhibitors by setting up the first service to tackle this problem in 1998. This procedure, termed "kinase profiling" proved to be of great help to the pharmaceutical industry, speeding up the development of specific protein kinase inhibitors with therapeutic potential. Since then many biotechnology companies, as well as academic drug discovery centres, have entered this area, and also need access to "kinase profiling" services at an affordable price. Our service is available to anyone that wishes to use it and our panel of protein kinases has now increased in size to 140. We have also launched a new lipid kinase profiling service in July 2012. The information in this website explains how "kinase profiling" is carried out and how it can be accessed by interested parties.
MRC PPU Reagents Our aim for the MRC-PPU is to operate as one of the world’s leading centers for the investigation of signal transduction pathways involving protein phosphorylation and ubiquitylation networks. We are also keen to make our range of essential resources and services available to aide with worldwide research in this area. To this end, we have decided to set up a simple user-friendly, web-based system whereby not-for-profit research groups can request clones, antibodies and proteins our unit possesses.