Welcome To Tom Owen-Hughes Lab

DNA provides a means of storing the genetic information required for life. Recently, dramatic progress has been made in the development of technologies that allow the large quantities of DNA that comprise eukaryotic genomes to be sequenced relatively quickly. The genome sequences for many organisms including humans are now well cataloged. However understanding how this information is regulated to ensure living organisms function correctly remains a considerable challenge and at the heart of our research programme.

DNA within eukaryotes is associated with proteins to form a condensed structure known as chromatin. This serves to physically package DNA within nuclei, but also provides a level at which access to genetic information can be regulated. A range of different strategies are used to alter the conformation of chromatin to ensure genes are regulated correctly. 

The projects ongoing in the lab involve studying some of these processes using a range of different approaches. These include biophysical and biochemical approaches to monitor the structure and mechanism of action of protein complexes together with genomics, proteomics and microscopy to study their functions. This is greatly assisted by the presence of excellent core facilities and colleagues within the Centre for Gene Regulation and Expression and School of Life Sciences
Our research involves collaborative interactions with a range of research groups worldwide. Sharing expertise and resources can often provide an enjoyable and productive means of progress.

Looking forward a major area of interest is to study the contribution of chromatin remodelling enzymes to cancer, see Projects for more information.

Confused? See our non-scientist description - Why what we do is important

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