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Investigating gene regulation during hypoxia at the University of Dundee

The Rocha Lab is now mainly funded by Cancer Research UK

Our latest article on the HIF-1/NF-kappaB crosstalk makes the cover!! See here !

- Latest Publications

-->Cezanne regulated E2F1-dependent HIF-2alpha expression.

-->HIF-1alpha, a novel piece in the NF-kappaB puzzle.

-->Dose dependent effects of Allopurinol on human foreskin fibroblast cell and human umbilical vein endothelial cells under hypoxia.

-->The role of Hypoxia in Inflammatory disease.

--> HIF-1alpha restricts NF-kappaB dependent gene expression to control innate immunity signals.

-->PITX1, a specificity determinant in the HIF-1alpha-mediated transcriptional response to hypoxia.

-->Cezanne (OTUD7B) regulates HIF-1alpha homeostasis in a proteasome-independent manner

-->Chromatin and oxygen sensing in the context of JmjC histone demethylases