Welcome to the website

Investigating gene regulation during hypoxia at the University of Dundee

The Rocha Lab is now mainly funded by Cancer Research UK

Our latest article on the HIF-1/NF-kappaB crosstalk makes the cover!! See here !

Sonia is now a Professor!

- Latest Publications

-->KDM2 family members are regulated by HIF-1 in hypoxia.

-->Potent and selective chemical probe of hypoxic signalling downstream of HIF-alpha hydroxylation via VHL inhibition.

-->Hypoxia Induced NF-kappaB

-->CDK dependent phosphorylation of PHD1 on Serine 130 alters its substrate preference in cells.

-->NF-kappaB and HIF crosstalk in immune responses.

-->Cezanne regulated E2F1-dependent HIF-2alpha expression.

-->Dose dependent effects of Allopurinol on human foreskin fibroblast cell and human umbilical vein endothelial cells under hypoxia.

-->The role of Hypoxia in Inflammatory disease.

--> HIF-1alpha restricts NF-kappaB dependent gene expression to control innate immunity signals.