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210: González AE, Muñoz VC, Cavieres VA, Bustamante HA, Cornejo VH, Januário YC, González I, Hetz C, daSilva LL, Rojas-Fernández A, Hay RT, Mardones GA, Burgos PV. Autophagosomes cooperate in the degradation of intracellular C-terminal fragments of the amyloid precursor protein via the MVB/lysosomal pathway. FASEB J. 2017 Jun;31(6):2446-2459. doi: 10.1096/fj.201600713R. Epub 2017 Mar 2. PubMed PMID: 28254759.

209: Tatham MH, Cole C, Scullion P, Wilkie R, Westwood NJ, Stark LA, Hay RT. A Proteomic Approach to Analyze the Aspirin-mediated Lysine Acetylome. Mol Cell Proteomics. 2017 Feb;16(2):310-326. doi: 10.1074/mcp.O116.065219. Epub 2016 Dec 2. PubMed PMID: 27913581; PubMed Central PMCID: PMC5294217.

208: Pelisch F, Tammsalu T, Wang B, Jaffray EG, Gartner A, Hay RT. A SUMO-Dependent Protein Network Regulates Chromosome Congression during Oocyte Meiosis. Mol Cell. 2017 Jan 5;65(1):66-77. doi: 10.1016/j.molcel.2016.11.001. Epub 2016 Dec 8. PubMed PMID: 27939944; PubMed Central PMCID: PMC5222697.

207: Maure JF, Moser SC, Jaffray EG, F Alpi A, Hay RT. Loss of ubiquitin E2 Ube2w rescues hypersensitivity of Rnf4 mutant cells to DNA damage. Sci Rep. 2016 May 17;6:26178. doi: 10.1038/srep26178. PubMed PMID: 27185577; PubMed Central PMCID: PMC4868978.

206: Shire K, Wong AI, Tatham MH, Anderson OF, Ripsman D, Gulstene S, Moffat J, Hay RT, Frappier L. Identification of RNF168 as a PML nuclear body regulator. J Cell Sci. 2016 Feb 1;129(3):580-91. doi: 10.1242/jcs.176446. Epub 2015 Dec 16. PubMed PMID: 26675234; PubMed Central PMCID: PMC4760303.

205: Maculins T, Carter N, Dorval T, Hudson K, Nissink JW, Hay RT, Alwan H. A Generic Platform for Cellular Screening Against Ubiquitin Ligases. Sci Rep. 2016 Jan 8;6:18940. doi: 10.1038/srep18940. PubMed PMID: 26743172; PubMed Central PMCID: PMC4705515.

204: Wimmer P, Berscheminski J, Blanchette P, Groitl P, Branton PE, Hay RT, Dobner T, Schreiner S. PML isoforms IV and V contribute to adenovirus-mediated oncogenic transformation by functionally inhibiting the tumor-suppressor p53. Oncogene. 2016 Jan 7;35(1):69-82. doi: 10.1038/onc.2015.63. Epub 2015 Mar 16. PubMed PMID: 25772236.

203: Pelisch F, Hay RT. Tools to Study SUMO Conjugation in Caenorhabditis elegans. Methods Mol Biol. 2016;1475:233-56. doi: 10.1007/978-1-4939-6358-4_17. PubMed PMID: 27631810.

202: Domingues P, Golebiowski F, Tatham MH, Lopes AM, Taggart A, Hay RT, Hale BG. Global Reprogramming of Host SUMOylation during Influenza Virus Infection. Cell Rep. 2015 Nov 17;13(7):1467-80. doi: 10.1016/j.celrep.2015.10.001. Epub 2015 Nov 5. PubMed PMID: 26549460; PubMed Central PMCID: PMC4660286.

201: Køhler JB, Tammsalu T, Jørgensen MM, Steen N, Hay RT, Thon G. Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast. Nat Commun. 2015 Nov 5;6:8827. doi: 10.1038/ncomms9827. PubMed PMID: 26537787; PubMed Central PMCID: PMC4667616.

200: Tammsalu T, Matic I, Jaffray EG, Ibrahim AF, Tatham MH, Hay RT. Proteome-wide identification of SUMO modification sites by mass spectrometry. Nat Protoc. 2015 Sep;10(9):1374-88. doi: 10.1038/nprot.2015.095. Epub 2015 Aug 20. PubMed PMID: 26292070.

199: Aguilar-Martinez E, Chen X, Webber A, Mould AP, Seifert A, Hay RT, Sharrocks AD. Screen for multi-SUMO-binding proteins reveals a multi-SIM-binding mechanism for recruitment of the transcriptional regulator ZMYM2 to chromatin. Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):E4854-63. doi: 10.1073/pnas.1509716112. Epub 2015 Aug 17. PubMed PMID: 26283374; PubMed Central PMCID: PMC4568223.

198: Branigan E, Plechanovová A, Jaffray EG, Naismith JH, Hay RT. Structural basis for the RING-catalyzed synthesis of K63-linked ubiquitin chains. Nat Struct Mol Biol. 2015 Aug;22(8):597-602. doi: 10.1038/nsmb.3052. Epub 2015 Jul 6. PubMed PMID: 26148049; PubMed Central PMCID: PMC4529489.

197: Sloan E, Tatham MH, Groslambert M, Glass M, Orr A, Hay RT, Everett RD. Analysis of the SUMO2 Proteome during HSV-1 Infection. PLoS Pathog. 2015 Jul 22;11(7):e1005059. doi: 10.1371/journal.ppat.1005059. eCollection 2015 Jul. PubMed PMID: 26200910; PubMed Central PMCID: PMC4511656.

196: Seifert A, Schofield P, Barton GJ, Hay RT. Proteotoxic stress reprograms the chromatin landscape of SUMO modification. Sci Signal. 2015 Jul 7;8(384):rs7. doi: 10.1126/scisignal.aaa2213. PubMed PMID: 26152697.

195: Rojas-Fernandez A, Herhaus L, Macartney T, Lachaud C, Hay RT, Sapkota GP. Rapid generation of endogenously driven transcriptional reporters in cells through CRISPR/Cas9. Sci Rep. 2015 Apr 29;5:9811. doi: 10.1038/srep09811. PubMed PMID: 25922883; PubMed Central PMCID: PMC4413877.

194: Bett JS, Ritorto MS, Ewan R, Jaffray EG, Virdee S, Chin JW, Knebel A, Kurz T, Trost M, Tatham MH, Hay RT. Ubiquitin C-terminal hydrolases cleave isopeptide- and peptide-linked ubiquitin from structured proteins but do not edit ubiquitin homopolymers. Biochem J. 2015 Mar 15;466(3):489-98. doi: 10.1042/BJ20141349. PubMed PMID: 25489924; PubMed Central PMCID: PMC4353193.

193: Pelisch F, Sonneville R, Pourkarimi E, Agostinho A, Blow JJ, Gartner A, Hay RT. Erratum: Dynamic SUMO modification regulates mitotic chromosome assembly and cell cycle progression in Caenorhabditis elegans. Nat Commun. 2015 Feb 12;6:6352. doi: 10.1038/ncomms7352. PubMed PMID: 25672768; PubMed Central PMCID: PMC4353261.

192: Pelisch F, Sonneville R, Pourkarimi E, Agostinho A, Blow JJ, Gartner A, Hay RT. Dynamic SUMO modification regulates mitotic chromosome assembly and cell cycle progression in Caenorhabditis elegans. Nat Commun. 2014 Dec 5;5:5485. doi: 10.1038/ncomms6485. Erratum in: Nat Commun. 2015;6:6352. PubMed PMID: 25475837; PubMed Central PMCID: PMC4268692.

191: Paraskevopoulos K, Kriegenburg F, Tatham MH, Rösner HI, Medina B, Larsen IB, Brandstrup R, Hardwick KG, Hay RT, Kragelund BB, Hartmann-Petersen R, Gordon C. Dss1 is a 26S proteasome ubiquitin receptor. Mol Cell. 2014 Nov 6;56(3):453-61. doi: 10.1016/j.molcel.2014.09.008. Epub 2014 Oct 9. PubMed PMID: 25306921; PubMed Central PMCID: PMC4232310.

190: Fritah S, Lhocine N, Golebiowski F, Mounier J, Andrieux A, Jouvion G, Hay RT, Sansonetti P, Dejean A. Sumoylation controls host anti-bacterial response to the gut invasive pathogen Shigella flexneri. EMBO Rep. 2014 Sep;15(9):965-72. doi: 10.15252/embr.201338386. Epub 2014 Aug 5. PubMed PMID: 25097252; PubMed Central PMCID: PMC4198040.

189: Vyas S, Matic I, Uchima L, Rood J, Zaja R, Hay RT, Ahel I, Chang P. Family-wide analysis of poly(ADP-ribose) polymerase activity. Nat Commun. 2014 Jul 21;5:4426. doi: 10.1038/ncomms5426. PubMed PMID: 25043379; PubMed Central PMCID: PMC4123609.

188: Lang V, Pallara C, Zabala A, Lobato-Gil S, Lopitz-Otsoa F, Farrás R, Hjerpe R, Torres-Ramos M, Zabaleta L, Blattner C, Hay RT, Barrio R, Carracedo A, Fernandez-Recio J, Rodríguez MS, Aillet F. Tetramerization-defects of p53 result in aberrant ubiquitylation and transcriptional activity. Mol Oncol. 2014 Jul;8(5):1026-42. doi: 10.1016/j.molonc.2014.04.002. Epub 2014 Apr 13. PubMed PMID: 24816189.

187: Xu Y, Plechanovová A, Simpson P, Marchant J, Leidecker O, Kraatz S, Hay RT, Matthews SJ. Structural insight into SUMO chain recognition and manipulation by the ubiquitin ligase RNF4. Nat Commun. 2014 Jun 27;5:4217. doi: 10.1038/ncomms5217. PubMed PMID: 24969970; PubMed Central PMCID: PMC4083429.

186: Berscheminski J, Wimmer P, Brun J, Ip WH, Groitl P, Horlacher T, Jaffray E, Hay RT, Dobner T, Schreiner S. Sp100 isoform-specific regulation of human adenovirus 5 gene expression. J Virol. 2014 Jun;88(11):6076-92. doi: 10.1128/JVI.00469-14. Epub 2014 Mar 12. PubMed PMID: 24623443; PubMed Central PMCID: PMC4093896.

185: Bett JS, Ibrahim AF, Garg AK, Rocha S, Hay RT. SiRNA screening to identify ubiquitin and ubiquitin-like system regulators of biological pathways in cultured mammalian cells. J Vis Exp. 2014 May 24;(87). doi: 10.3791/51572. PubMed PMID: 24893647; PubMed Central PMCID: PMC4207135.

184: Tammsalu T, Matic I, Jaffray EG, Ibrahim AFM, Tatham MH, Hay RT. Proteome-wide identification of SUMO2 modification sites. Sci Signal. 2014 Apr 29;7(323):rs2. doi: 10.1126/scisignal.2005146. PubMed PMID: 24782567; PubMed Central PMCID: PMC4051997.

183: MacKay C, Carroll E, Ibrahim AFM, Garg A, Inman GJ, Hay RT, Alpi AF. E3 ubiquitin ligase HOIP attenuates apoptotic cell death induced by cisplatin. Cancer Res. 2014 Apr 15;74(8):2246-2257. doi: 10.1158/0008-5472.CAN-13-2131. Epub 2014 Mar 31. PubMed PMID: 24686174; PubMed Central PMCID: PMC3990471.

182: Rojas-Fernandez A, Plechanovová A, Hattersley N, Jaffray E, Tatham MH, Hay RT. SUMO chain-induced dimerization activates RNF4. Mol Cell. 2014 Mar 20;53(6):880-92. doi: 10.1016/j.molcel.2014.02.031. PubMed PMID: 24656128; PubMed Central PMCID: PMC3991395.

181: Hands KJ, Cuchet-Lourenco D, Everett RD, Hay RT. PML isoforms in response to arsenic: high-resolution analysis of PML body structure and degradation. J Cell Sci. 2014 Jan 15;127(Pt 2):365-75. doi: 10.1242/jcs.132290. Epub 2013 Nov 4. PubMed PMID: 24190887; PubMed Central PMCID: PMC3889398.

180: Citro S, Jaffray E, Hay RT, Seiser C, Chiocca S. A role for paralog-specific sumoylation in histone deacetylase 1 stability. J Mol Cell Biol. 2013 Dec;5(6):416-27. doi: 10.1093/jmcb/mjt032. Epub 2013 Sep 25. PubMed PMID: 24068740.

179: Pozzebon ME, Varadaraj A, Mattoscio D, Jaffray EG, Miccolo C, Galimberti V, Tommasino M, Hay RT, Chiocca S. BC-box protein domain-related mechanism for VHL protein degradation. Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18168-73. doi: 10.1073/pnas.1311382110. Epub 2013 Oct 21. PubMed PMID: 24145437; PubMed Central PMCID: PMC3831490.

178: Tatham MH, Plechanovová A, Jaffray EG, Salmen H, Hay RT. Ube2W conjugates ubiquitin to α-amino groups of protein N-termini. Biochem J. 2013 Jul 1;453(1):137-45. doi: 10.1042/BJ20130244. PubMed PMID: 23560854; PubMed Central PMCID: PMC3778709.

177: Bett JS, Ibrahim AF, Garg AK, Kelly V, Pedrioli P, Rocha S, Hay RT. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. Biochem J. 2013 Apr 15;451(2):185-94. doi: 10.1042/BJ20130026. PubMed PMID: 23398456; PubMed Central PMCID: PMC3632086.

176: Hay RT. Decoding the SUMO signal. Biochem Soc Trans. 2013 Apr;41(2):463-73. doi: 10.1042/BST20130015. Review. PubMed PMID: 23514139.

175: Plechanovová A, Jaffray EG, Tatham MH, Naismith JH, Hay RT. Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis. Nature. 2012 Sep 6;489(7414):115-20. doi: 10.1038/nature11376. PubMed PMID: 22842904; PubMed Central PMCID: PMC3442243.

174: Zhou W, Hannoun Z, Jaffray E, Medine CN, Black JR, Greenhough S, Zhu L, Ross JA, Forbes S, Wilmut I, Iredale JP, Hay RT, Hay DC. SUMOylation of HNF4α regulates protein stability and hepatocyte function. J Cell Sci. 2012 Aug 1;125(Pt 15):3630-5. Epub 2012 Apr 14. PubMed PMID: 22505616; PubMed Central PMCID: PMC3445325.

173: Matic I, Ahel I, Hay RT. Reanalysis of phosphoproteomics data uncovers ADP-ribosylation sites. Nat Methods. 2012 Jul 30;9(8):771-2. doi: 10.1038/nmeth.2106. PubMed PMID: 22847107; PubMed Central PMCID: PMC3428868.

172: Yin Y, Seifert A, Chua JS, Maure JF, Golebiowski F, Hay RT. SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage. Genes Dev. 2012 Jun 1;26(11):1196-208. doi: 10.1101/gad.189274.112. PubMed PMID: 22661230; PubMed Central PMCID: PMC3371408.

171: Allan C, Burel JM, Moore J, Blackburn C, Linkert M, Loynton S, Macdonald D, Moore WJ, Neves C, Patterson A, Porter M, Tarkowska A, Loranger B, Avondo J, Lagerstedt I, Lianas L, Leo S, Hands K, Hay RT, Patwardhan A, Best C, Kleywegt GJ, Zanetti G, Swedlow JR. OMERO: flexible, model-driven data management for experimental biology. Nat Methods. 2012 Feb 28;9(3):245-53. doi: 10.1038/nmeth.1896. PubMed PMID: 22373911; PubMed Central PMCID: PMC3437820.

170: Matic I, Hay RT. Detection and quantitation of SUMO chains by mass spectrometry. Methods Mol Biol. 2012;832:239-47. doi: 10.1007/978-1-61779-474-2_17. PubMed PMID: 22350890.

169: Aillet F, Lopitz-Otsoa F, Egaña I, Hjerpe R, Fraser P, Hay RT, Rodriguez MS, Lang V. Heterologous SUMO-2/3-ubiquitin chains optimize IκBα degradation and NF-κB activity. PLoS One. 2012;7(12):e51672. doi: 10.1371/journal.pone.0051672. Epub 2012 Dec 20. PubMed PMID: 23284737; PubMed Central PMCID: PMC3527444.

168: Matic I, Jaffray EG, Oxenham SK, Groves MJ, Barratt CL, Tauro S, Stanley-Wall NR, Hay RT. Absolute SILAC-compatible expression strain allows Sumo-2 copy number determination in clinical samples. J Proteome Res. 2011 Oct 7;10(10):4869-75. doi: 10.1021/pr2004715. Epub 2011 Aug 25. PubMed PMID: 21830832; PubMed Central PMCID: PMC3189705.

167: Larance M, Bailly AP, Pourkarimi E, Hay RT, Buchanan G, Coulthurst S, Xirodimas DP, Gartner A, Lamond AI. Stable-isotope labeling with amino acids in nematodes. Nat Methods. 2011 Aug 28;8(10):849-51. doi: 10.1038/nmeth.1679. PubMed PMID: 21874007; PubMed Central PMCID: PMC3184259.

166: Plechanovová A, Jaffray EG, McMahon SA, Johnson KA, Navrátilová I, Naismith JH, Hay RT. Mechanism of ubiquitylation by dimeric RING ligase RNF4. Nat Struct Mol Biol. 2011 Aug 21;18(9):1052-9. doi: 10.1038/nsmb.2108. PubMed PMID: 21857666; PubMed Central PMCID: PMC3326525.

165: Tatham MH, Matic I, Mann M, Hay RT. Comparative proteomic analysis identifies a role for SUMO in protein quality control. Sci Signal. 2011 Jun 21;4(178):rs4. doi: 10.1126/scisignal.2001484. PubMed PMID: 21693764.

164: Napolitano LM, Jaffray EG, Hay RT, Meroni G. Functional interactions between ubiquitin E2 enzymes and TRIM proteins. Biochem J. 2011 Mar 1;434(2):309-19. doi: 10.1042/BJ20101487. PubMed PMID: 21143188.

163: Bruderer R, Tatham MH, Plechanovova A, Matic I, Garg AK, Hay RT. Purification and identification of endogenous polySUMO conjugates. EMBO Rep. 2011 Feb;12(2):142-8. doi: 10.1038/embor.2010.206. Epub 2011 Jan 21. PubMed PMID: 21252943; PubMed Central PMCID: PMC3049431.

162: Hattersley N, Shen L, Jaffray EG, Hay RT. The SUMO protease SENP6 is a direct regulator of PML nuclear bodies. Mol Biol Cell. 2011 Jan 1;22(1):78-90. doi: 10.1091/mbc.E10-06-0504. Epub 2010 Dec 9. PubMed PMID: 21148299; PubMed Central PMCID: PMC3016979.

161: Hannoun Z, Greenhough S, Jaffray E, Hay RT, Hay DC. Post-translational modification by SUMO. Toxicology. 2010 Dec 30;278(3):288-93. doi: 10.1016/j.tox.2010.07.013. Epub 2010 Jul 30. Review. PubMed PMID: 20674646.

160: Geoffroy MC, Jaffray EG, Walker KJ, Hay RT. Arsenic-induced SUMO-dependent recruitment of RNF4 into PML nuclear bodies. Mol Biol Cell. 2010 Dec;21(23):4227-39. doi: 10.1091/mbc.E10-05-0449. Epub 2010 Oct 13. PubMed PMID: 20943951; PubMed Central PMCID: PMC2993750.

159: Castillo-Lluva S, Tatham MH, Jones RC, Jaffray EG, Edmondson RD, Hay RT, Malliri A. SUMOylation of the GTPase Rac1 is required for optimal cell migration. Nat Cell Biol. 2010 Nov;12(11):1078-85. doi: 10.1038/ncb2112. Epub 2010 Oct 10. PubMed PMID: 20935639; PubMed Central PMCID: PMC2992316.

158: Hjerpe R, Aillet F, Lopitz-Otsoa F, Lang V, Torres-Ramos M, Farrás R, Hay RT, Rodríguez MS. Oligomerization conditions Mdm2-mediated efficient p53 polyubiquitylation but not its proteasomal degradation. Int J Biochem Cell Biol. 2010 May;42(5):725-35. doi: 10.1016/j.biocel.2010.01.010. Epub 2010 Jan 18. PubMed PMID: 20080206.

157: Golebiowski F, Tatham MH, Nakamura A, Hay RT. High-stringency tandem affinity purification of proteins conjugated to ubiquitin-like moieties. Nat Protoc. 2010 May;5(5):873-82. doi: 10.1038/nprot.2010.40. Epub 2010 Apr 15. PubMed PMID: 20431533.

156: Li X, Vadrevu S, Dunlop A, Day J, Advant N, Troeger J, Klussmann E, Jaffrey E, Hay RT, Adams DR, Houslay MD, Baillie GS. Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK. Biochem J. 2010 Apr 28;428(1):55-65. doi: 10.1042/BJ20091672. PubMed PMID: 20196770.

155: Makiyi EF, Frade RF, Lebl T, Jaffray EG, Cobb SE, Harvey AL, Slawin AM, Hay RT, Westwood NJ. Iso-seco-tanapartholides: Isolation, Synthesis and Biological Evaluation. European J Org Chem. 2009 Nov;2009(33):5711-5715. Epub 2009 Oct 7. PubMed PMID: 23606807; PubMed Central PMCID: PMC3627315.

154: Lake A, Shield LA, Cordano P, Chui DT, Osborne J, Crae S, Wilson KS, Tosi S, Knight SJ, Gesk S, Siebert R, Hay RT, Jarrett RF. Mutations of NFKBIA, encoding IkappaB alpha, are a recurrent finding in classical Hodgkin lymphoma but are not a unifying feature of non-EBV-associated cases. Int J Cancer. 2009 Sep 15;125(6):1334-42. doi: 10.1002/ijc.24502. PubMed PMID: 19507254.

153: Geoffroy MC, Hay RT. An additional role for SUMO in ubiquitin-mediated proteolysis. Nat Rev Mol Cell Biol. 2009 Aug;10(8):564-8. doi: 10.1038/nrm2707. Epub 2009 May 28. Review. PubMed PMID: 19474794.

152: Shen LN, Geoffroy MC, Jaffray EG, Hay RT. Characterization of SENP7, a SUMO-2/3-specific isopeptidase. Biochem J. 2009 Jun 26;421(2):223-30. doi: 10.1042/BJ20090246. PubMed PMID: 19392659.

151: Golebiowski F, Matic I, Tatham MH, Cole C, Yin Y, Nakamura A, Cox J, Barton GJ, Mann M, Hay RT. System-wide changes to SUMO modifications in response to heat shock. Sci Signal. 2009 May 26;2(72):ra24. doi: 10.1126/scisignal.2000282. PubMed PMID: 19471022.

150: Tatham MH, Hay RT. FRET-based in vitro assays for the analysis of SUMO protease activities. Methods Mol Biol. 2009;497:253-68. doi: 10.1007/978-1-59745-566-4_17. Review. PubMed PMID: 19107423.

149: Tatham MH, Rodriguez MS, Xirodimas DP, Hay RT. Detection of protein SUMOylation in vivo. Nat Protoc. 2009;4(9):1363-71. doi: 10.1038/nprot.2009.128. Epub 2009 Sep 3. PubMed PMID: 19730420.

148: Miles WO, Jaffray E, Campbell SG, Takeda S, Bayston LJ, Basu SP, Li M, Raftery LA, Ashe MP, Hay RT, Ashe HL. Medea SUMOylation restricts the signaling range of the Dpp morphogen in the Drosophila embryo. Genes Dev. 2008 Sep 15;22(18):2578-90. doi: 10.1101/gad.494808. PubMed PMID: 18794353; PubMed Central PMCID: PMC2546696.

147: Richard DJ, Bolderson E, Cubeddu L, Wadsworth RI, Savage K, Sharma GG, Nicolette ML, Tsvetanov S, McIlwraith MJ, Pandita RK, Takeda S, Hay RT, Gautier J, West SC, Paull TT, Pandita TK, White MF, Khanna KK. Single-stranded DNA-binding protein hSSB1 is critical for genomic stability. Nature. 2008 May 29;453(7195):677-81. doi: 10.1038/nature06883. Epub 2008 Apr 30. PubMed PMID: 18449195.

146: Tatham MH, Geoffroy MC, Shen L, Plechanovova A, Hattersley N, Jaffray EG, Palvimo JJ, Hay RT. RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation. Nat Cell Biol. 2008 May;10(5):538-46. doi: 10.1038/ncb1716. Epub 2008 Apr 13. PubMed PMID: 18408734.

145: Agostinho M, Santos V, Ferreira F, Costa R, Cardoso J, Pinheiro I, Rino J, Jaffray E, Hay RT, Ferreira J. Conjugation of human topoisomerase 2 alpha with small ubiquitin-like modifiers 2/3 in response to topoisomerase inhibitors: cell cycle stage and chromosome domain specificity. Cancer Res. 2008 Apr 1;68(7):2409-18. doi: 10.1158/0008-5472.CAN-07-2092. Erratum in: Cancer Res. 2008 Apr 15;68(8):3076. PubMed PMID: 18381449.

144: Watson MR, Wallace K, Gieling RG, Manas DM, Jaffray E, Hay RT, Mann DA, Oakley F. NF-kappaB is a critical regulator of the survival of rodent and human hepatic myofibroblasts. J Hepatol. 2008 Apr;48(4):589-97. doi: 10.1016/j.jhep.2007.12.019. Epub 2008 Jan 31. PubMed PMID: 18279996.

143: Martin SF, Tatham MH, Hay RT, Samuel ID. Quantitative analysis of multi-protein interactions using FRET: application to the SUMO pathway. Protein Sci. 2008 Apr;17(4):777-84. doi: 10.1110/ps.073369608. PubMed PMID: 18359863; PubMed Central PMCID: PMC2271167.

142: Xirodimas DP, Sundqvist A, Nakamura A, Shen L, Botting C, Hay RT. Ribosomal proteins are targets for the NEDD8 pathway. EMBO Rep. 2008 Mar;9(3):280-6. doi: 10.1038/embor.2008.10. Epub 2008 Feb 15. PubMed PMID: 18274552; PubMed Central PMCID: PMC2267383.

141: Matic I, van Hagen M, Schimmel J, Macek B, Ogg SC, Tatham MH, Hay RT, Lamond AI, Mann M, Vertegaal ACO. In vivo identification of human small ubiquitin-like modifier polymerization sites by high accuracy mass spectrometry and an in vitro to in vivo strategy. Mol Cell Proteomics. 2008 Jan;7(1):132-44. doi: 10.1074/mcp.M700173-MCP200. Epub 2007 Oct 15. PubMed PMID: 17938407; PubMed Central PMCID: PMC3840926.

140: Jacobs AM, Nicol SM, Hislop RG, Jaffray EG, Hay RT, Fuller-Pace FV. SUMO modification of the DEAD box protein p68 modulates its transcriptional activity and promotes its interaction with HDAC1. Oncogene. 2007 Aug 30;26(40):5866-76. Epub 2007 Mar 19. PubMed PMID: 17369852.

139: Tillmanns S, Otto C, Jaffray E, Du Roure C, Bakri Y, Vanhille L, Sarrazin S, Hay RT, Sieweke MH. SUMO modification regulates MafB-driven macrophage differentiation by enabling Myb-dependent transcriptional repression. Mol Cell Biol. 2007 Aug;27(15):5554-64. Epub 2007 Jun 4. PubMed PMID: 17548468; PubMed Central PMCID: PMC1952098.

138: Hay RT. SUMO-specific proteases: a twist in the tail. Trends Cell Biol. 2007 Aug;17(8):370-6. Epub 2007 Sep 4. Review. PubMed PMID: 17768054.

137: Dorval V, Mazzella MJ, Mathews PM, Hay RT, Fraser PE. Modulation of Abeta generation by small ubiquitin-like modifiers does not require conjugation to target proteins. Biochem J. 2007 Jun 1;404(2):309-16. PubMed PMID: 17346237; PubMed Central PMCID: PMC1868795.

136: Martin SF, Hattersley N, Samuel ID, Hay RT, Tatham MH. A fluorescence-resonance-energy-transfer-based protease activity assay and its use to monitor paralog-specific small ubiquitin-like modifier processing. Anal Biochem. 2007 Apr 1;363(1):83-90. Epub 2007 Jan 4. PubMed PMID: 17288980.

135: Meinecke I, Cinski A, Baier A, Peters MA, Dankbar B, Wille A, Drynda A, Mendoza H, Gay RE, Hay RT, Ink B, Gay S, Pap T. Modification of nuclear PML protein by SUMO-1 regulates Fas-induced apoptosis in rheumatoid arthritis synovial fibroblasts. Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5073-8. Epub 2007 Mar 14. PubMed PMID: 17360386; PubMed Central PMCID: PMC1829266.

134: Janssen K, Hofmann TG, Jans DA, Hay RT, Schulze-Osthoff K, Fischer U. Apoptin is modified by SUMO conjugation and targeted to promyelocytic leukemia protein nuclear bodies. Oncogene. 2007 Mar 8;26(11):1557-66. Epub 2006 Aug 21. PubMed PMID: 16924230.

133: Vertegaal AC, Andersen JS, Ogg SC, Hay RT, Mann M, Lamond AI. Distinct and overlapping sets of SUMO-1 and SUMO-2 target proteins revealed by quantitative proteomics. Mol Cell Proteomics. 2006 Dec;5(12):2298-310. Epub 2006 Sep 25. PubMed PMID: 17000644.

132: Shen L, Tatham MH, Dong C, Zagórska A, Naismith JH, Hay RT. SUMO protease SENP1 induces isomerization of the scissile peptide bond. Nat Struct Mol Biol. 2006 Dec;13(12):1069-77. Epub 2006 Nov 12. PubMed PMID: 17099698; PubMed Central PMCID: PMC3326531.

131: Cockman ME, Lancaster DE, Stolze IP, Hewitson KS, McDonough MA, Coleman ML, Coles CH, Yu X, Hay RT, Ley SC, Pugh CW, Oldham NJ, Masson N, Schofield CJ, Ratcliffe PJ. Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH). Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14767-72. Epub 2006 Sep 26. PubMed PMID: 17003112; PubMed Central PMCID: PMC1578504.

130: Shen LN, Dong C, Liu H, Naismith JH, Hay RT. The structure of SENP1-SUMO-2 complex suggests a structural basis for discrimination between SUMO paralogues during processing. Biochem J. 2006 Jul 15;397(2):279-88. PubMed PMID: 16553580; PubMed Central PMCID: PMC1513277.

129: Fernández-Lloris R, Osses N, Jaffray E, Shen LN, Vaughan OA, Girwood D, Bartrons R, Rosa JL, Hay RT, Ventura F. Repression of SOX6 transcriptional activity by SUMO modification. FEBS Lett. 2006 Feb 20;580(5):1215-21. Epub 2006 Jan 20. PubMed PMID: 16442531.

128: Hay RT. Role of ubiquitin-like proteins in transcriptional regulation. Ernst Schering Res Found Workshop. 2006;(57):173-92. Review. PubMed PMID: 16568955.

127: Jaffray EG, Hay RT. Detection of modification by ubiquitin-like proteins. Methods. 2006 Jan;38(1):35-8. PubMed PMID: 16343933.

126: Desterro JM, Keegan LP, Jaffray E, Hay RT, O'Connell MA, Carmo-Fonseca M. SUMO-1 modification alters ADAR1 editing activity. Mol Biol Cell. 2005 Nov;16(11):5115-26. Epub 2005 Aug 24. PubMed PMID: 16120648; PubMed Central PMCID: PMC1266412.

125: Cooper HJ, Tatham MH, Jaffray E, Heath JK, Lam TT, Marshall AG, Hay RT. Fourier transform ion cyclotron resonance mass spectrometry for the analysis of small ubiquitin-like modifier (SUMO) modification: identification of lysines in RanBP2 and SUMO targeted for modification during the E3 autoSUMOylation reaction. Anal Chem. 2005 Oct 1;77(19):6310-9. PubMed PMID: 16194093.

124: Hofmann TG, Jaffray E, Stollberg N, Hay RT, Will H. Regulation of homeodomain-interacting protein kinase 2 (HIPK2) effector function through dynamic small ubiquitin-related modifier-1 (SUMO-1) modification. J Biol Chem. 2005 Aug 12;280(32):29224-32. Epub 2005 Jun 15. PubMed PMID: 15958389.

123: Degerny C, Monte D, Beaudoin C, Jaffray E, Portois L, Hay RT, de Launoit Y, Baert JL. SUMO modification of the Ets-related transcription factor ERM inhibits its transcriptional activity. J Biol Chem. 2005 Jul 1;280(26):24330-8. Epub 2005 Apr 27. PubMed PMID: 15857832.

122: Shen LN, Liu H, Dong C, Xirodimas D, Naismith JH, Hay RT. Structural basis of NEDD8 ubiquitin discrimination by the deNEDDylating enzyme NEDP1. EMBO J. 2005 Apr 6;24(7):1341-51. Epub 2005 Mar 17. PubMed PMID: 15775960; PubMed Central PMCID: PMC1142549.

121: Hay RT. SUMO: a history of modification. Mol Cell. 2005 Apr 1;18(1):1-12. Review. PubMed PMID: 15808504.

120: Boyer-Guittaut M, Birsoy K, Potel C, Elliott G, Jaffray E, Desterro JM, Hay RT, Oelgeschläger T. SUMO-1 modification of human transcription factor (TF) IID complex subunits: inhibition of TFIID promoter-binding activity through SUMO-1 modification of hsTAF5. J Biol Chem. 2005 Mar 18;280(11):9937-45. Epub 2005 Jan 6. PubMed PMID: 15637059.

119: Bouras T, Fu M, Sauve AA, Wang F, Quong AA, Perkins ND, Hay RT, Gu W, Pestell RG. SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1. J Biol Chem. 2005 Mar 18;280(11):10264-76. Epub 2005 Jan 4. PubMed PMID: 15632193.

118: Fujihara S, Jaffray E, Farrow SN, Rossi AG, Haslett C, Hay RT. Inhibition of NF-kappa B by a cell permeable form of I kappa B alpha induces apoptosis in eosinophils. Biochem Biophys Res Commun. 2005 Jan 21;326(3):632-7. PubMed PMID: 15596146.

117: Ghioni P, D'Alessandra Y, Mansueto G, Jaffray E, Hay RT, La Mantia G, Guerrini L. The protein stability and transcriptional activity of p63alpha are regulated by SUMO-1 conjugation. Cell Cycle. 2005 Jan;4(1):183-90. Epub 2005 Jan 10. PubMed PMID: 15611636.

116: Tatham MH, Kim S, Jaffray E, Song J, Chen Y, Hay RT. Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection. Nat Struct Mol Biol. 2005 Jan;12(1):67-74. Epub 2004 Dec 19. PubMed PMID: 15608651.

115: Cooper HJ, Heath JK, Jaffray E, Hay RT, Lam TT, Marshall AG. Identification of sites of ubiquitination in proteins: a fourier transform ion cyclotron resonance mass spectrometry approach. Anal Chem. 2004 Dec 1;76(23):6982-8. PubMed PMID: 15571350.

114: Boggio R, Colombo R, Hay RT, Draetta GF, Chiocca S. A mechanism for inhibiting the SUMO pathway. Mol Cell. 2004 Nov 19;16(4):549-61. PubMed PMID: 15546615.

113: Honkavuori KS, Pollard BD, Rodriguez MS, Hay RT, Kemp GD. Dual role of the adenovirus pVI C terminus as a nuclear localization signal and activator of the viral protease. J Gen Virol. 2004 Nov;85(Pt 11):3367-76. PubMed PMID: 15483253.

112: Vertegaal AC, Ogg SC, Jaffray E, Rodriguez MS, Hay RT, Andersen JS, Mann M, Lamond AI. A proteomic study of SUMO-2 target proteins. J Biol Chem. 2004 Aug 6;279(32):33791-8. Epub 2004 Jun 2. PubMed PMID: 15175327.

111: Argasinska J, Zhou K, Donnelly RJ, Hay RT, Lee CG. A functional interaction between RHA and Ubc9, an E2-like enzyme specific for Sumo-1. J Mol Biol. 2004 Jul 30;341(1):15-25. PubMed PMID: 15312759.

110: Xirodimas DP, Saville MK, Bourdon JC, Hay RT, Lane DP. Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity. Cell. 2004 Jul 9;118(1):83-97. PubMed PMID: 15242646.

109: Girdwood DW, Tatham MH, Hay RT. SUMO and transcriptional regulation. Semin Cell Dev Biol. 2004 Apr;15(2):201-10. Review. PubMed PMID: 15209380.

108: Smolle M, Hay RT, Byron O. Hydrodynamic bead modelling of the 2:1 p50-IkappaBgamma complex. Biophys Chem. 2004 Mar 1;108(1-3):259-71. PubMed PMID: 15043934.

107: Hay RT. Modifying NEMO. Nat Cell Biol. 2004 Feb;6(2):89-91. PubMed PMID: 14755268.

106: Yang SH, Jaffray E, Senthinathan B, Hay RT, Sharrocks AD. SUMO and transcriptional repression: dynamic interactions between the MAP kinase and SUMO pathways. Cell Cycle. 2003 Nov-Dec;2(6):528-30. Review. PubMed PMID: 14504467.

105: Hay DC, Beers C, Cameron V, Thomson L, Flitney FW, Hay RT. Activation of NF-kappaB nuclear transcription factor by flow in human endothelial cells. Biochim Biophys Acta. 2003 Sep 23;1642(1-2):33-44. PubMed PMID: 12972291.

104: Tatham MH, Kim S, Yu B, Jaffray E, Song J, Zheng J, Rodriguez MS, Hay RT, Chen Y. Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation. Biochemistry. 2003 Aug 26;42(33):9959-69. PubMed PMID: 12924945.

103: Mendoza HM, Shen LN, Botting C, Lewis A, Chen J, Ink B, Hay RT. NEDP1, a highly conserved cysteine protease that deNEDDylates Cullins. J Biol Chem. 2003 Jul 11;278(28):25637-43. Epub 2003 May 1. PubMed PMID: 12730221.

102: Yang SH, Jaffray E, Hay RT, Sharrocks AD. Dynamic interplay of the SUMO and ERK pathways in regulating Elk-1 transcriptional activity. Mol Cell. 2003 Jul;12(1):63-74. PubMed PMID: 12887893.

101: Girdwood D, Bumpass D, Vaughan OA, Thain A, Anderson LA, Snowden AW, Garcia-Wilson E, Perkins ND, Hay RT. P300 transcriptional repression is mediated by SUMO modification. Mol Cell. 2003 Apr;11(4):1043-54. PubMed PMID: 12718889.

100: Tatham MH, Chen Y, Hay RT. Role of two residues proximal to the active site of Ubc9 in substrate recognition by the Ubc9.SUMO-1 thiolester complex. Biochemistry. 2003 Mar 25;42(11):3168-79. PubMed PMID: 12641448.

99: Liu H, Naismith JH, Hay RT. Adenovirus DNA replication. Curr Top Microbiol Immunol. 2003;272:131-64. Review. PubMed PMID: 12747549.

98: Lang V, Janzen J, Fischer GZ, Soneji Y, Beinke S, Salmeron A, Allen H, Hay RT, Ben-Neriah Y, Ley SC. betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932. Mol Cell Biol. 2003 Jan;23(1):402-13. PubMed PMID: 12482991; PubMed Central PMCID: PMC140687.

97: Xirodimas DP, Chisholm J, Desterro JM, Lane DP, Hay RT. P14ARF promotes accumulation of SUMO-1 conjugated (H)Mdm2. FEBS Lett. 2002 Sep 25;528(1-3):207-11. PubMed PMID: 12297306.

96: Lin D, Tatham MH, Yu B, Kim S, Hay RT, Chen Y. Identification of a substrate recognition site on Ubc9. J Biol Chem. 2002 Jun 14;277(24):21740-8. Epub 2002 Mar 4. PubMed PMID: 11877416.

95: Fu M, Wang C, Wang J, Zhang X, Sakamaki T, Yeung YG, Chang C, Hopp T, Fuqua SA, Jaffray E, Hay RT, Palvimo JJ, Jänne OA, Pestell RG. Androgen receptor acetylation governs trans activation and MEKK1-induced apoptosis without affecting in vitro sumoylation and trans-repression function. Mol Cell Biol. 2002 May;22(10):3373-88. PubMed PMID: 11971970; PubMed Central PMCID: PMC133781.

94: Fujihara S, Ward C, Dransfield I, Hay RT, Uings IJ, Hayes B, Farrow SN, Haslett C, Rossi AG. Inhibition of nuclear factor-kappaB activation un-masks the ability of TNF-alpha to induce human eosinophil apoptosis. Eur J Immunol. 2002 Feb;32(2):457-66. PubMed PMID: 11813164.

93: Tatham MH, Jaffray E, Vaughan OA, Desterro JM, Botting CH, Naismith JH, Hay RT. Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9. J Biol Chem. 2001 Sep 21;276(38):35368-74. Epub 2001 Jul 12. PubMed PMID: 11451954.

92: Botting CH, Hay RT. Role of conserved residues in the activity of adenovirus preterminal protein. J Gen Virol. 2001 Aug;82(Pt 8):1917-27. PubMed PMID: 11457998.

91: Hay DC, Kemp GD, Dargemont C, Hay RT. Interaction between hnRNPA1 and IkappaBalpha is required for maximal activation of NF-kappaB-dependent transcription. Mol Cell Biol. 2001 May;21(10):3482-90. PubMed PMID: 11313474; PubMed Central PMCID: PMC100270.

90: Seeler JS, Marchio A, Losson R, Desterro JM, Hay RT, Chambon P, Dejean A. Common properties of nuclear body protein SP100 and TIF1alpha chromatin factor: role of SUMO modification. Mol Cell Biol. 2001 May;21(10):3314-24. PubMed PMID: 11313457; PubMed Central PMCID: PMC100253.

89: Hay RT. Protein modification by SUMO. Trends Biochem Sci. 2001 May;26(5):332-3. PubMed PMID: 11343927.

88: Rodriguez MS, Dargemont C, Hay RT. SUMO-1 conjugation in vivo requires both a consensus modification motif and nuclear targeting. J Biol Chem. 2001 Apr 20;276(16):12654-9. Epub 2000 Dec 21. PubMed PMID: 11124955.

87: Liu H, Naismith JH, Hay RT. Identification of conserved residues contributing to the activities of adenovirus DNA polymerase. J Virol. 2000 Dec;74(24):11681-9. PubMed PMID: 11090167; PubMed Central PMCID: PMC112450.

86: Rodriguez MS, Desterro JM, Lain S, Lane DP, Hay RT. Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation. Mol Cell Biol. 2000 Nov;20(22):8458-67. PubMed PMID: 11046142; PubMed Central PMCID: PMC102152.

85: Gildow FE, Reavy B, Mayo MA, Duncan GH, Woodford JA, Lamb JW, Hay RT. Aphid Acquisition and Cellular Transport of Potato leafroll virus-like Particles Lacking P5 Readthrough Protein. Phytopathology. 2000 Oct;90(10):1153-61. doi: 10.1094/PHYTO.2000.90.10.1153. PubMed PMID: 18944480.

84: Desterro JM, Rodriguez MS, Hay RT. Regulation of transcription factors by protein degradation. Cell Mol Life Sci. 2000 Aug;57(8-9):1207-19. Review. PubMed PMID: 11028913.

83: Jiménez LA, Thompson J, Brown DA, Rahman I, Antonicelli F, Duffin R, Drost EM, Hay RT, Donaldson K, MacNee W. Activation of NF-kappaB by PM(10) occurs via an iron-mediated mechanism in the absence of IkappaB degradation. Toxicol Appl Pharmacol. 2000 Jul 15;166(2):101-10. PubMed PMID: 10896851.

82: Midgley CA, Desterro JM, Saville MK, Howard S, Sparks A, Hay RT, Lane DP. An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo. Oncogene. 2000 May 4;19(19):2312-23. PubMed PMID: 10822382.

81: Clarkson RW, Heeley JL, Chapman R, Aillet F, Hay RT, Wyllie A, Watson CJ. NF-kappaB inhibits apoptosis in murine mammary epithelia. J Biol Chem. 2000 Apr 28;275(17):12737-42. PubMed PMID: 10777569.

80: Middleton G, Hamanoue M, Enokido Y, Wyatt S, Pennica D, Jaffray E, Hay RT, Davies AM. Cytokine-induced nuclear factor kappa B activation promotes the survival of developing neurons. J Cell Biol. 2000 Jan 24;148(2):325-32. PubMed PMID: 10648565; PubMed Central PMCID: PMC2174280.

79: Rodriguez MS, Desterro JM, Lain S, Midgley CA, Lane DP, Hay RT. SUMO-1 modification activates the transcriptional response of p53. EMBO J. 1999 Nov 15;18(22):6455-61. PubMed PMID: 10562557; PubMed Central PMCID: PMC1171708.

78: Hay RT, Vuillard L, Desterro JM, Rodriguez MS. Control of NF-kappa B transcriptional activation by signal induced proteolysis of I kappa B alpha. Philos Trans R Soc Lond B Biol Sci. 1999 Sep 29;354(1389):1601-9. Review. PubMed PMID: 10582246; PubMed Central PMCID: PMC1692667.

77: Elsharkawy AM, Wright MC, Hay RT, Arthur MJ, Hughes T, Bahr MJ, Degitz K, Mann DA. Persistent activation of nuclear factor-kappaB in cultured rat hepatic stellate cells involves the induction of potentially novel Rel-like factors and prolonged changes in the expression of IkappaB family proteins. Hepatology. 1999 Sep;30(3):761-9. PubMed PMID: 10462383.

76: Vuillard L, Nicholson J, Hay RT. A complex containing betaTrCP recruits Cdc34 to catalyse ubiquitination of IkappaBalpha. FEBS Lett. 1999 Jul 23;455(3):311-4. PubMed PMID: 10437795.

75: Hamanoue M, Middleton G, Wyatt S, Jaffray E, Hay RT, Davies AM. p75-mediated NF-kappaB activation enhances the survival response of developing sensory neurons to nerve growth factor. Mol Cell Neurosci. 1999 Jul;14(1):28-40. PubMed PMID: 10433815.

74: Botting CH, Hay RT. Characterisation of the adenovirus preterminal protein and its interaction with the POU homeodomain of NFIII (Oct-1). Nucleic Acids Res. 1999 Jul 1;27(13):2799-805. PubMed PMID: 10373599; PubMed Central PMCID: PMC148491.

73: Cabannes E, Khan G, Aillet F, Jarrett RF, Hay RT. Mutations in the IkBa gene in Hodgkin's disease suggest a tumour suppressor role for IkappaBalpha. Oncogene. 1999 May 20;18(20):3063-70. PubMed PMID: 10340377.

72: Baghdiguian S, Martin M, Richard I, Pons F, Astier C, Bourg N, Hay RT, Chemaly R, Halaby G, Loiselet J, Anderson LV, Lopez de Munain A, Fardeau M, Mangeat P, Beckmann JS, Lefranc G. Calpain 3 deficiency is associated with myonuclear apoptosis and profound perturbation of the IkappaB alpha/NF-kappaB pathway in limb-girdle muscular dystrophy type 2A. Nat Med. 1999 May;5(5):503-11. Erratum in: Nat Med 1999 Jul;5(7):849. PubMed PMID: 10229226.

71: Desterro JM, Rodriguez MS, Kemp GD, Hay RT. Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1. J Biol Chem. 1999 Apr 9;274(15):10618-24. PubMed PMID: 10187858.

70: Rodriguez MS, Thompson J, Hay RT, Dargemont C. Nuclear retention of IkappaBalpha protects it from signal-induced degradation and inhibits nuclear factor kappaB transcriptional activation. J Biol Chem. 1999 Mar 26;274(13):9108-15. PubMed PMID: 10085161.

69: Turpin P, Hay RT, Dargemont C. Characterization of IkappaBalpha nuclear import pathway. J Biol Chem. 1999 Mar 5;274(10):6804-12. PubMed PMID: 10037782.

68: Duprez E, Saurin AJ, Desterro JM, Lallemand-Breitenbach V, Howe K, Boddy MN, Solomon E, de Thé H, Hay RT, Freemont PS. SUMO-1 modification of the acute promyelocytic leukaemia protein PML: implications for nuclear localisation. J Cell Sci. 1999 Feb;112 ( Pt 3):381-93. PubMed PMID: 9885291.

67: Michalopoulos I, Hay RT. Role of the conserved lysine 80 in stabilisation of NF-kappaB p50 DNA binding. Nucleic Acids Res. 1999 Jan 15;27(2):503-9. PubMed PMID: 9862972; PubMed Central PMCID: PMC148207.

66: Desterro JM, Rodriguez MS, Hay RT. SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation. Mol Cell. 1998 Aug;2(2):233-9. PubMed PMID: 9734360.

65: Wood KM, Roff M, Hay RT. Defective IkappaBalpha in Hodgkin cell lines with constitutively active NF-kappaB. Oncogene. 1998 Apr 23;16(16):2131-9. PubMed PMID: 9572494.

64: Stark LA, Hay RT. Human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) interacts with Lys-tRNA synthetase: implications for priming of HIV-1 reverse transcription. J Virol. 1998 Apr;72(4):3037-44. PubMed PMID: 9525626; PubMed Central PMCID: PMC109751.

63: Parker EJ, Botting CH, Webster A, Hay RT. Adenovirus DNA polymerase: domain organisation and interaction with preterminal protein. Nucleic Acids Res. 1998 Mar 1;26(5):1240-7. PubMed PMID: 9469832; PubMed Central PMCID: PMC147410.

62: Desterro JM, Thomson J, Hay RT. Ubch9 conjugates SUMO but not ubiquitin. FEBS Lett. 1997 Nov 17;417(3):297-300. PubMed PMID: 9409737.

61: Kroll M, Conconi M, Desterro MJ, Marin A, Thomas D, Friguet B, Hay RT, Virelizier JL, Arenzana-Seisdedos F, Rodriguez MS. The carboxy-terminus of I kappaB alpha determines susceptibility to degradation by the catalytic core of the proteasome. Oncogene. 1997 Oct 9;15(15):1841-50. PubMed PMID: 9362451.

60: Webster A, Leith IR, Nicholson J, Hounsell J, Hay RT. Role of preterminal protein processing in adenovirus replication. J Virol. 1997 Sep;71(9):6381-9. PubMed PMID: 9261355; PubMed Central PMCID: PMC191911.

59: Arenzana-Seisdedos F, Turpin P, Rodriguez M, Thomas D, Hay RT, Virelizier JL, Dargemont C. Nuclear localization of I kappa B alpha promotes active transport of NF-kappa B from the nucleus to the cytoplasm. J Cell Sci. 1997 Feb;110 ( Pt 3):369-78. PubMed PMID: 9057089.

58: Webster A, Leith IR, Hay RT. Domain organization of the adenovirus preterminal protein. J Virol. 1997 Jan;71(1):539-47. PubMed PMID: 8985382; PubMed Central PMCID: PMC191083.

57: Bell S, Matthews JR, Jaffray E, Hay RT. I(kappa)B(gamma) inhibits DNA binding of NF-kappaB p50 homodimers by interacting with residues that contact DNA. Mol Cell Biol. 1996 Nov;16(11):6477-85. PubMed PMID: 8887676; PubMed Central PMCID: PMC231649.

56: Monaghan A, Hay RT. Pyridoxal 5'-phosphate inhibition of adenovirus DNA polymerase. J Biol Chem. 1996 Sep 27;271(39):24242-8. PubMed PMID: 8798669.

55: Lamb JW, Duncan GH, Reavy B, Gildow FE, Mayo MA, Hay RT. Assembly of virus-like particles in insect cells infected with a baculovirus containing a modified coat protein gene of potato leafroll luteovirus. J Gen Virol. 1996 Jul;77 ( Pt 7):1349-58. PubMed PMID: 8757974.

54: Matthews JR, Botting CH, Panico M, Morris HR, Hay RT. Inhibition of NF-kappaB DNA binding by nitric oxide. Nucleic Acids Res. 1996 Jun 15;24(12):2236-42. PubMed PMID: 8710491; PubMed Central PMCID: PMC145924.

53: Rodriguez MS, Wright J, Thompson J, Thomas D, Baleux F, Virelizier JL, Hay RT, Arenzana-Seisdedos F. Identification of lysine residues required for signal-induced ubiquitination and degradation of I kappa B-alpha in vivo. Oncogene. 1996 Jun 6;12(11):2425-35. PubMed PMID: 8649784.

52: Roff M, Thompson J, Rodriguez MS, Jacque JM, Baleux F, Arenzana-Seisdedos F, Hay RT. Role of IkappaBalpha ubiquitination in signal-induced activation of NFkappaB in vivo. J Biol Chem. 1996 Mar 29;271(13):7844-50. PubMed PMID: 8631829.

51: Matthews JR, Nicholson J, Jaffray E, Kelly SM, Price NC, Hay RT. Conformational changes induced by DNA binding of NF-kappa B. Nucleic Acids Res. 1995 Sep 11;23(17):3393-402. PubMed PMID: 7567448; PubMed Central PMCID: PMC307216.

50: Matthews JR, Hay RT. Regulation of the DNA binding activity of NF-kappa B. Int J Biochem Cell Biol. 1995 Sep;27(9):865-79. Review. PubMed PMID: 7584622.

49: Arenzana-Seisdedos F, Thompson J, Rodriguez MS, Bachelerie F, Thomas D, Hay RT. Inducible nuclear expression of newly synthesized I kappa B alpha negatively regulates DNA-binding and transcriptional activities of NF-kappa B. Mol Cell Biol. 1995 May;15(5):2689-96. PubMed PMID: 7739549; PubMed Central PMCID: PMC230499.

48: Rodriguez MS, Michalopoulos I, Arenzana-Seisdedos F, Hay RT. Inducible degradation of I kappa B alpha in vitro and in vivo requires the acidic C-terminal domain of the protein. Mol Cell Biol. 1995 May;15(5):2413-9. PubMed PMID: 7739525; PubMed Central PMCID: PMC230470.

47: Alcamí J, Laín de Lera T, Folgueira L, Pedraza MA, Jacqué JM, Bachelerie F, Noriega AR, Hay RT, Harrich D, Gaynor RB, et al. Absolute dependence on kappa B responsive elements for initiation and Tat-mediated amplification of HIV transcription in blood CD4 T lymphocytes. EMBO J. 1995 Apr 3;14(7):1552-60. PubMed PMID: 7729429; PubMed Central PMCID: PMC398242.

46: Jaffray E, Wood KM, Hay RT. Domain organization of I kappa B alpha and sites of interaction with NF-kappa B p65. Mol Cell Biol. 1995 Apr;15(4):2166-72. PubMed PMID: 7891711; PubMed Central PMCID: PMC230444.

45: Hay RT, Freeman A, Leith I, Monaghan A, Webster A. Molecular interactions during adenovirus DNA replication. Curr Top Microbiol Immunol. 1995;199 ( Pt 2):31-48. Review. PubMed PMID: 7555069.

44: Webster A, Leith IR, Hay RT. Activation of adenovirus-coded protease and processing of preterminal protein. J Virol. 1994 Nov;68(11):7292-300. PubMed PMID: 7933113; PubMed Central PMCID: PMC237170.

43: Diaz-Meco MT, Dominguez I, Sanz L, Dent P, Lozano J, Municio MM, Berra E, Hay RT, Sturgill TW, Moscat J. zeta PKC induces phosphorylation and inactivation of I kappa B-alpha in vitro. EMBO J. 1994 Jun 15;13(12):2842-8. PubMed PMID: 8026469; PubMed Central PMCID: PMC395165.

42: Monaghan A, Webster A, Hay RT. Adenovirus DNA binding protein: helix destabilising properties. Nucleic Acids Res. 1994 Mar 11;22(5):742-8. PubMed PMID: 8139913; PubMed Central PMCID: PMC307877.

41: Crompton J, Toogood CI, Wallis N, Hay RT. Expression of a foreign epitope on the surface of the adenovirus hexon. J Gen Virol. 1994 Jan;75 ( Pt 1):133-9. PubMed PMID: 7509367.

40: Mellits KH, Hay RT, Goodbourn S. Proteolytic degradation of MAD3 (I kappa B alpha) and enhanced processing of the NF-kappa B precursor p105 are obligatory steps in the activation of NF-kappa B. Nucleic Acids Res. 1993 Nov 11;21(22):5059-66. PubMed PMID: 8255759; PubMed Central PMCID: PMC310617.

39: Hay RT. Control of nuclear factor-kappa B DNA-binding activity by inhibitory proteins containing ankyrin repeats. Biochem Soc Trans. 1993 Nov;21(4):926-30. Review. PubMed PMID: 8132095.

38: Hay RT, Nicholson J. DNA binding alters the protease susceptibility of the p50 subunit of NF-kappa B. Nucleic Acids Res. 1993 Sep 25;21(19):4592-8. PubMed PMID: 8233795; PubMed Central PMCID: PMC311195.

37: Matthews JR, Watson E, Buckley S, Hay RT. Interaction of the C-terminal region of p105 with the nuclear localisation signal of p50 is required for inhibition of NF-kappa B DNA binding activity. Nucleic Acids Res. 1993 Sep 25;21(19):4516-23. PubMed PMID: 7694229; PubMed Central PMCID: PMC311184.

36: Matthews JR, Kaszubska W, Turcatti G, Wells TN, Hay RT. Role of cysteine62 in DNA recognition by the P50 subunit of NF-kappa B. Nucleic Acids Res. 1993 Apr 25;21(8):1727-34. PubMed PMID: 8493089; PubMed Central PMCID: PMC309407.

35: Webster A, Hay RT, Kemp G. The adenovirus protease is activated by a virus-coded disulphide-linked peptide. Cell. 1993 Jan 15;72(1):97-104. PubMed PMID: 8422686.

34: Paya CV, Ten RM, Bessia C, Alcami J, Hay RT, Virelizier JL. NF-kappa B-dependent induction of the NF-kappa B p50 subunit gene promoter underlies self-perpetuation of human immunodeficiency virus transcription in monocytic cells. Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7826-30. PubMed PMID: 1502202; PubMed Central PMCID: PMC49804.

33: Matthews JR, Wakasugi N, Virelizier JL, Yodoi J, Hay RT. Thioredoxin regulates the DNA binding activity of NF-kappa B by reduction of a disulphide bond involving cysteine 62. Nucleic Acids Res. 1992 Aug 11;20(15):3821-30. PubMed PMID: 1508666; PubMed Central PMCID: PMC334054.

32: Toogood CI, Crompton J, Hay RT. Antipeptide antisera define neutralizing epitopes on the adenovirus hexon. J Gen Virol. 1992 Jun;73 ( Pt 6):1429-35. PubMed PMID: 1376769.

31: Bosher J, Dawson A, Hay RT. Nuclear factor I is specifically targeted to discrete subnuclear sites in adenovirus type 2-infected cells. J Virol. 1992 May;66(5):3140-50. PubMed PMID: 1560540; PubMed Central PMCID: PMC241077.

30: Temperley SM, Hay RT. Recognition of the adenovirus type 2 origin of DNA replication by the virally encoded DNA polymerase and preterminal proteins. EMBO J. 1992 Feb;11(2):761-8. PubMed PMID: 1537347; PubMed Central PMCID: PMC556509.

29: Bosher J, Leith IR, Temperley SM, Wells M, Hay RT. The DNA-binding domain of nuclear factor I is sufficient to cooperate with the adenovirus type 2 DNA-binding protein in viral DNA replication. J Gen Virol. 1991 Dec;72 ( Pt 12):2975-80. PubMed PMID: 1765770.

28: Temperley SM, Burrow CR, Kelly TJ, Hay RT. Identification of two distinct regions within the adenovirus minimal origin of replication that are required for adenovirus type 4 DNA replication in vitro. J Virol. 1991 Sep;65(9):5037-44. PubMed PMID: 1870210; PubMed Central PMCID: PMC248967.

27: Temperley SM, Hay RT. Replication of adenovirus type 4 DNA by a purified fraction from infected cells. Nucleic Acids Res. 1991 Jun 25;19(12):3243-9. PubMed PMID: 1829516; PubMed Central PMCID: PMC328317.

26: Bosher J, Robinson EC, Hay RT. Interactions between the adenovirus type 2 DNA polymerase and the DNA binding domain of nuclear factor I. New Biol. 1990 Dec;2(12):1083-90. PubMed PMID: 2088500.

25: Lamb JW, Hay RT. Ribozymes that cleave potato leafroll virus RNA within the coat protein and polymerase genes. J Gen Virol. 1990 Oct;71 ( Pt 10):2257-64. PubMed PMID: 2230733.

24: Bahner I, Lamb J, Mayo MA, Hay RT. Expression of the genome of potato leafroll virus: readthrough of the coat protein termination codon in vivo. J Gen Virol. 1990 Oct;71 ( Pt 10):2251-6. PubMed PMID: 2230732.

23: Watson CJ, Hay RT. Expression of adenovirus type 2 DNA polymerase in insect cells infected with a recombinant baculovirus. Nucleic Acids Res. 1990 Mar 11;18(5):1167-73. PubMed PMID: 2181402; PubMed Central PMCID: PMC330431.

22: Clark L, Matthews JR, Hay RT. Interaction of enhancer-binding protein EBP1 (NF-kappa B) with the human immunodeficiency virus type 1 enhancer. J Virol. 1990 Mar;64(3):1335-44. PubMed PMID: 2406459; PubMed Central PMCID: PMC249252.

21: Leith IR, Hay RT, Russell WC. Adenovirus subviral particles and cores can support limited DNA replication. J Gen Virol. 1989 Dec;70 ( Pt 12):3235-48. PubMed PMID: 2607337.

20: Toogood CI, Murali R, Burnett RM, Hay RT. The adenovirus type 40 hexon: sequence, predicted structure and relationship to other adenovirus hexons. J Gen Virol. 1989 Dec;70 ( Pt 12):3203-14. PubMed PMID: 2481711.

19: Cleat PH, Hay RT. Co-operative interactions between NFI and the adenovirus DNA binding protein at the adenovirus origin of replication. EMBO J. 1989 Jun;8(6):1841-8. PubMed PMID: 2767055; PubMed Central PMCID: PMC401031.

18: Clark L, Nicholson J, Hay RT. Enhancer binding protein (EBP1) makes base and backbone contacts over one complete turn of the DNA double helix. J Mol Biol. 1989 Apr 20;206(4):615-26. PubMed PMID: 2544731.

17: Hay RT, Russell WC. Recognition mechanisms in the synthesis of animal virus DNA. Biochem J. 1989 Feb 15;258(1):3-16. Review. PubMed PMID: 2649089; PubMed Central PMCID: PMC1138317.

16: Clark L, Hay RT. Sequence requirement for specific interaction of an enhancer binding protein (EBP1) with DNA. Nucleic Acids Res. 1989 Jan 25;17(2):499-516. PubMed PMID: 2536920; PubMed Central PMCID: PMC331599.

15: Leith IR, Hay RT, Russell WC. Detection of Z DNA binding proteins in tissue culture cells. Nucleic Acids Res. 1988 Sep 12;16(17):8277-89. PubMed PMID: 3419919; PubMed Central PMCID: PMC338558.

14: Toogood CI, Hay RT. DNA sequence of the adenovirus type 41 hexon gene and predicted structure of the protein. J Gen Virol. 1988 Sep;69 ( Pt 9):2291-301. PubMed PMID: 3411299.

13: Clark L, Pollock RM, Hay RT. Identification and purification of EBP1: a HeLa cell protein that binds to a region overlapping the 'core' of the SV40 enhancer. Genes Dev. 1988 Aug;2(8):991-1002. PubMed PMID: 2844627.

12: Harris MP, Hay RT. DNA sequences required for the initiation of adenovirus type 4 DNA replication in vitro. J Mol Biol. 1988 May 5;201(1):57-67. PubMed PMID: 3418700.

11: Barrett P, Clark L, Hay RT. A cellular protein binds to a conserved sequence in the adenovirus type 2 enhancer. Nucleic Acids Res. 1987 Mar 25;15(6):2719-35. PubMed PMID: 3031610; PubMed Central PMCID: PMC340680.

10: Hay RT, Barrett P, Clark L, Harris M. The role of sequence-specific DNA-binding proteins in adenovirus DNA replication. J Cell Sci Suppl. 1987;7:51-65. PubMed PMID: 3503889.

9: Hay RT, McDougall IM. Viable viruses with deletions in the left inverted terminal repeat define the adenovirus origin of DNA replication. J Gen Virol. 1986 Feb;67 ( Pt 2):321-32. PubMed PMID: 3003240.

8: Hay RT. Origin of adenovirus DNA replication. Role of the nuclear factor I binding site in vivo. J Mol Biol. 1985 Nov 5;186(1):129-36. PubMed PMID: 4078897.

7: Hay RT. The origin of adenovirus DNA replication: minimal DNA sequence requirement in vivo. EMBO J. 1985 Feb;4(2):421-6. PubMed PMID: 4018031; PubMed Central PMCID: PMC554202.

6: Hay RT, Stow ND, McDougall IM. Replication of adenovirus mini-chromosomes. J Mol Biol. 1984 Jun 5;175(4):493-510. PubMed PMID: 6737476.

5: Hay RT, Hendrickson EA, DePamphilis ML. Sequence specificity for the initiation of RNA-primed simian virus 40 DNA synthesis in vivo. J Mol Biol. 1984 May 15;175(2):131-57. PubMed PMID: 6202875.

4: Hay RT, DePamphilis ML. Initiation of SV40 DNA replication in vivo: location and structure of 5' ends of DNA synthesized in the ori region. Cell. 1982 Apr;28(4):767-79. PubMed PMID: 6178514.

3: Hay RT, Hay J. Characteristics of chromatin preparations from herpes simplex virus infected cells. Biochim Biophys Acta. 1981 Aug 27;655(1):71-81. PubMed PMID: 6266485.

2: Hay RT, Hay J. Properties of herpesvirus-induced "immediate early" polypeptides. Virology. 1980 Jul 15;104(1):230-4. PubMed PMID: 6249025.

1: Hay RT, Hay J. Synthesis of herpes simplex virus DNA in preparations of chromatin from infected cell nuclei. J Gen Virol. 1978 Nov;41(2):427-31. PubMed PMID: 214524.


 

 

 
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