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This is a full list of publications. For publications by individuals please see the personal pages. Allan C, Burel JM, Moore J, Blackburn C, Linkert M, Loynton S, Macdonald D, Moore WJ, Neves C, Patterson A, Porter M, Tarkowska A, Loranger B, Avondo J, Lagerstedt I, Lianas L, Leo S, Hands K, Hay RT, Patwardhan A, Best C, Kleywegt GJ, Zanetti G, Swedlow JR. OMERO: flexible, model-driven data management for experimental biology. Nat Methods. 2012 Feb 28;9(3):245-53. doi: 10.1038/nmeth.1896 Matic I, Hay RT. Detection and Quantitation of SUMO Chains by Mass Spectrometry. Methods Mol Biol. 2012;832:239-47. Larance M, Bailly AP, Pourkarimi E, Hay RT, Buchanan G, Coulthurst S, Xirodimas DP, Gartner A, Lamond AI. Stable-isotope labeling with amino acids in nematodes. Nat Methods. 2011 Aug 28;8(10):849-51. doi: 10.1038/nmeth.1679. Matic I, Jaffray EG, Oxenham SK, Groves MJ, Barratt CL, Tauro S, Stanley-Wall NR, Hay RT. Absolute SILAC-compatible expression strain allows Sumo-2 copy number determination in clinical samples. J Proteome Res. 2011 Oct 7;10(10):4869-75. Epub 2011 Aug 25. Plechanovová A, Jaffray EG, McMahon SA, Johnson KA, Navrátilová I, Naismith JH, Hay RT. Mechanism of ubiquitylation by dimeric RING ligase RNF4. Nat Struct Mol Biol. 2011 Aug 21;18(9):1052-9. doi: 10.1038/nsmb.2108. Tatham MH, Matic I, Mann M, Hay RT. Comparative Proteomic Analysis Identifies a Role for SUMO in Protein Quality Control. Sci Signal. 2011 Jun 21;4(178):rs4. Summary , Abstract , Reprint , Full Text Napolitano LM, Jaffray EG, Hay RT, Meroni G. Functional interactions between ubiquitin E2 enzymes and TRIM proteins. Biochem J. 2011 Mar 1;434(2):309-19. Bruderer R, Tatham MH, Plechanovova A, Matic I, Garg AK, Hay RT. Purification and identification of endogenous polySUMO conjugates. EMBO Rep. 2011 Feb;12(2):142-8. Epub 2011 Jan 21. Hattersley N, Shen L, Jaffray EG, Hay RT. The SUMO protease SENP6 is a direct regulator of PML nuclear bodies. Mol Biol Cell. 2011 Jan 1;22(1):78-90. Epub 2010 Dec 9. Golebiowski F, Tatham MH, Nakamura A, Hay RT. High-stringency tandem affinity purification of proteins conjugated to ubiquitin-like moieties. Nat Protoc. 2010;5(5):873-82. Epub 2010 Apr 15.PMID: 20431533 Geoffroy MC, Jaffray EG, Walker KJ, Hay RT. Arsenic-induced SUMO-dependent recruitment of RNF4 into PML nuclear bodies. Mol Biol Cell. 2010 Dec;21(23):4227-39. Epub 2010 Oct 13. Castillo-Lluva S, Tatham MH, Jones RC, Jaffray EG, Edmondson RD, Hay RT, Malliri A. SUMOylation of the GTPase Rac1 is required for optimal cell migration. Nat Cell Biol. 2010 Nov;12(11):1078-85. Epub 2010 Oct 10. Tatham MH, Rodriguez MS, Xirodimas DP, Hay RT.Detection of protein SUMOylation in vivo. Nat Protoc. 2009;4(9):1363-71. Epub 2009 Sep 3.PMID: 19730420 Geoffroy MC, Hay RT.An additional role for SUMO in ubiquitin-mediated proteolysis. Nat Rev Mol Cell Biol. 2009 Aug;10(8):564-8. Epub 2009 May 28. Review.PMID: 19474794 Golebiowski F, Matic I, Tatham MH, Cole C, Yin Y, Nakamura A, Cox J, Barton GJ, Mann M, Hay RT. System-wide changes to SUMO modifications in response to heat shock. Sci Signal. 2009 May 26;2(72):ra24.PMID: 19471022 Shen LN, Geoffroy MC, Jaffray EG, Hay RT. Characterization of SENP7, a SUMO-2/3-specific isopeptidase. Biochem J. 2009 Jun 26;421(2):223-30.PMID: 19392659 Tatham MH, Hay RT. FRET-based in vitro assays for the analysis of SUMO protease activities. Methods Mol Biol. 2009;497:253-68. Review.PMID: 19107423 Miles WO, Jaffray EG, Campbell SG, Takeda S , Bayston LJ, Basu SP, Raftery LA, Ashe MP, Hay RT and Ashe HL. Medea SUMOylation restricts the signalling range of the Dpp morphogen in the Drosophila embryo. Genes and Development 2008 Sep 15;22(18):2578-90. 1: Richard DJ, Bolderson E, Cubeddu L, Wadsworth RI, Savage K, Sharma GG, Nicolette ML, Tsvetanov S, McIlwraith MJ, Pandita RK, Takeda S, Hay RT, Gautier J, West SC, Paull TT, Pandita TK, White MF, Khanna KK. Single-stranded DNA-binding protein hSSB1 is critical for genomic stability. Nature. 2008 May 29;453(7195):677-81. Epub 2008 Apr 30. PMID: 18449195 *2: Tatham MH, Geoffroy MC, Shen L, Plechanovova A, Hattersley N, Jaffray EG, Palvimo JJ, Hay RT. RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation. Nat Cell Biol. 2008 May;10(5):538-46. Epub 2008 Apr 13. PMID: 18408734 3: Agostinho M, Santos V, Ferreira F, Costa R, Cardoso J, Pinheiro I, Rino J, Jaffray E, Hay RT, Ferreira J. Conjugation of human topoisomerase 2 alpha with small ubiquitin-like modifiers 2/3 in response to topoisomerase inhibitors: cell cycle stage and chromosome domain specificity. Cancer Res. 2008 Apr 1;68(7):2409-18. Erratum in: Cancer Res. 2008 Apr 15;68(8):3076. PMID: 18381449 4: Martin SF, Tatham MH, Hay RT, Samuel ID. Quantitative analysis of multi-protein interactions using FRET: application to the SUMO pathway. Protein Sci. 2008 Apr;17(4):777-84. PMID: 18359863 5: Watson MR, Wallace K, Gieling RG, Manas DM, Jaffray E, Hay RT, Mann DA, Oakley F. NF-kappaB is a critical regulator of the survival of rodent and human hepatic myofibroblasts. J Hepatol. 2008 Apr;48(4):589-97. Epub 2008 Jan 31. PMID: 18279996 6: Xirodimas DP, Sundqvist A, Nakamura A, Shen L, Botting C, Hay RT. Ribosomal proteins are targets for the NEDD8 pathway. EMBO Rep. 2008 Mar;9(3):280-6. Epub 2008 Feb 15. PMID: 18274552 7: Matic I, van Hagen M, Schimmel J, Macek B, Ogg SC, Tatham MH, Hay RT, Lamond
AI, Mann M, Vertegaal AC. In vivo identification of human small ubiquitin-like modifier polymerization sites by high accuracy mass spectrometry and an in vitro to in vivo strategy. Mol Cell Proteomics. 2008 Jan;7(1):132-44. Epub 2007 Oct 15. 8: Hay RT. SUMO-specific proteases: a twist in the tail. Trends Cell Biol. 2007 Aug;17(8):370-6. Epub 2007 Sep 4. Review. PMID: 17768054 9: Tillmanns S, Otto C, Jaffray E, Du Roure C, Bakri Y, Vanhille L, Sarrazin S, Hay RT, Sieweke MH. SUMO modification regulates MafB-driven macrophage differentiation by enabling Myb-dependent transcriptional repression. Mol Cell Biol. 2007 Aug;27(15):5554-64. Epub 2007 Jun 4. PMID: 17548468 10: Jacobs AM, Nicol SM, Hislop RG, Jaffray EG, Hay RT, Fuller-Pace FV. SUMO modification of the DEAD box protein p68 modulates its transcriptional activity and promotes its interaction with HDAC1. Oncogene. 2007 Mar 19; [Epub ahead of print] PMID: 17369852 11: Meinecke I, Cinski A, Baier A, Peters MA, Dankbar B, Wille A, Drynda A, Mendoza H, Gay RE, Hay RT, Ink B, Gay S, Pap T. Modification of nuclear PML protein by SUMO-1 regulates Fas-induced apoptosis in rheumatoid arthritis synovial fibroblasts. Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5073-8. PMID: 17360386 12: Dorval V, Mazzella MJ, Mathews PM, Hay RT, Fraser PE. Modulation of Abeta generation by small ubiquitin-like modifiers does not require conjugation to target proteins. Biochem J. 2007 Jun 1;404(2):309-16. PMID: 17346237 13: Martin SF, Hattersley N, Samuel ID, Hay RT, Tatham MH. A fluorescence-resonance-energy-transfer-based protease activity assay and its use to monitor paralog-specific small ubiquitin-like modifier processing. Anal Biochem. 2007 Apr 1;363(1):83-90. PMID: 17288980 *14: Shen L, Tatham MH, Dong C, Zagorska A, Naismith JH, Hay RT. SUMO protease SENP1 induces isomerization of the scissile peptide bond. Nat Struct Mol Biol. 2006 Dec;13(12):1069-77. PMID: 17099698 15: Cockman ME, Lancaster DE, Stolze IP, Hewitson KS, McDonough MA, Coleman ML, Coles CH, Yu X, Hay RT, Ley SC, Pugh CW, Oldham NJ, Masson N, Schofield CJ, Ratcliffe PJ. Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH). Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14767-72. Epub 2006 Sep 26. PMID: 17003112 16: Vertegaal AC, Andersen JS, Ogg SC, Hay RT, Mann M, Lamond AI. Distinct and overlapping sets of SUMO-1 and SUMO-2 target proteins revealed by quantitative proteomics. Mol Cell Proteomics. 2006 Dec;5(12):2298-310. PMID: 17000644 17: Janssen K, Hofmann TG, Jans DA, Hay RT, Schulze-Osthoff K, Fischer U. Apoptin is modified by SUMO conjugation and targeted to promyelocytic leukemia protein nuclear bodies. Oncogene. 2007 Mar 8;26(11):1557-66. PMID: 16924230 18: Hay RT. Role of ubiquitin-like proteins in transcriptional regulation. Ernst Schering Res Found Workshop. 2006;(57):173-92. PMID: 16568955 19: Shen LN, Dong C, Liu H, Naismith JH, Hay RT. The structure of SENP1-SUMO-2 complex suggests a structural basis for discrimination between SUMO paralogues during processing. Biochem J. 2006 Jul 15;397(2):279-88. PMID: 16553580 20: Fernandez-Lloris R, Osses N, Jaffray E, Shen LN, Vaughan OA, Girwood D, Bartrons R, Rosa JL, Hay RT, Ventura F. Repression of SOX6 transcriptional activity by SUMO modification. FEBS Lett. 2006 Feb 20;580(5):1215-21. PMID: 16442531 21: Jaffray EG, Hay RT. Detection of modification by ubiquitin-like proteins. Methods. 2006 Jan;38(1):35-8. PMID: 16343933 22: Cooper HJ, Tatham MH, Jaffray E, Heath JK, Lam TT, Marshall AG, Hay RT. Fourier transform ion cyclotron resonance mass spectrometry for the analysis of small ubiquitin-like modifier (SUMO) modification: identification of lysines in RanBP2 and SUMO targeted for modification during the E3 autoSUMOylation reaction. Anal Chem. 2005 Oct 1;77(19):6310-9. PMID: 16194093 23: Desterro JM, Keegan LP, Jaffray E, Hay RT, O'Connell MA, Carmo-Fonseca M. SUMO-1 modification alters ADAR1 editing activity. 24: Hofmann TG, Jaffray E, Stollberg N, Hay RT, Will H. Regulation of homeodomain-interacting protein kinase 2 (HIPK2) effector function through dynamic small ubiquitin-related modifier-1 (SUMO-1) modification. J Biol Chem. 2005 Aug 12;280(32):29224-32. PMID: 15958389 25: Degerny C, Monte D, Beaudoin C, Jaffray E, Portois L, Hay RT, de Launoit Y, Baert JL. SUMO modification of the Ets-related transcription factor ERM inhibits its transcriptional activity. J Biol Chem. 2005 Jul 1;280(26):24330-8. PMID: 15857832 26: Hay RT. SUMO: a history of modification. Mol Cell. 2005 Apr 1;18(1):1-12. PMID: 15808504 *27: Shen LN, Liu H, Dong C, Xirodimas D, Naismith JH, Hay RT. Structural basis of NEDD8 ubiquitin discrimination by the deNEDDylating enzyme NEDP1. EMBO J. 2005 Apr 6;24(7):1341-51. PMID: 15775960 28: Boyer-Guittaut M, Birsoy K, Potel C, Elliott G, Jaffray E, Desterro JM, Hay RT, Oelgeschlager T. SUMO-1 modification of human transcription factor (TF) IID complex subunits: inhibition of TFIID promoter-binding activity through SUMO-1 modification of hsTAF5. J Biol Chem. 2005 Mar 18;280(11):9937-45. PMID: 15637059 29: Bouras T, Fu M, Sauve AA, Wang F, Quong AA, Perkins ND, Hay RT, Gu W, Pestell RG. SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1. J Biol Chem. 2005 Mar 18;280(11):10264-76. PMID: 15632193 30: Ghioni P, D'Alessandra Y, Mansueto G, Jaffray E, Hay RT, La Mantia G, Guerrini L. The protein stability and transcriptional activity of p63alpha are regulated by SUMO-1 conjugation. Cell Cycle. 2005 Jan;4(1):183-90. PMID: 15611636 *31: Tatham MH, Kim S, Jaffray E, Song J, Chen Y, Hay RT. Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection. Nat Struct Mol Biol. 2005 Jan;12(1):67-74. PMID: 15608651 32: Fujihara S, Jaffray E, Farrow SN, Rossi AG, Haslett C, Hay RT. Inhibition of NF-kappa B by a cell permeable form of I kappa B alpha induces apoptosis in eosinophils. Biochem Biophys Res Commun. 2005 Jan 21;326(3):632-7. PMID: 15596146 33: Cooper HJ, Heath JK, Jaffray E, Hay RT, Lam TT, Marshall AG. Identification of sites of ubiquitination in proteins: a fourier transform ion cyclotron resonance mass spectrometry approach. Anal Chem. 2004 Dec 1;76(23):6982-8. PMID: 15571350 34: Boggio R, Colombo R, Hay RT, Draetta GF, Chiocca S. A mechanism for inhibiting the SUMO pathway. Mol Cell. 2004 Nov 19;16(4):549-61. PMID: 15546615 35: Honkavuori KS, Pollard BD, Rodriguez MS, Hay RT, Kemp GD. Dual role of the adenovirus pVI C terminus as a nuclear localization signal and activator of the viral protease. J Gen Virol. 2004 Nov;85(Pt 11):3367-76. PMID: 15483253 36: Argasinska J, Zhou K, Donnelly RJ, Hay RT, Lee CG. 37: Xirodimas DP, Saville MK, Bourdon JC, Hay RT, Lane DP. Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity. Cell. 2004 Jul 9;118(1):83-97. PMID: 15242646 38: Girdwood DW, Tatham MH, Hay RT. SUMO and transcriptional regulation. Semin Cell Dev Biol. 2004 Apr;15(2):201-10. PMID: 15209380 39: Vertegaal AC, Ogg SC, Jaffray E, Rodriguez MS, Hay RT, Andersen JS, Mann M, Lamond AI. A proteomic study of SUMO-2 target proteins. J Biol Chem. 2004 Aug 6;279(32):33791-8. PMID: 15175327 40: Smolle M, Hay RT, Byron O. Hydrodynamic bead modelling of the 2:1 p50-IkappaBgamma complex. Biophys Chem. 2004 Mar 1;108(1-3):259-71. PMID: 15043934 41: Hay RT. Modifying NEMO. Nat Cell Biol. 2004 Feb;6(2):89-91. No abstract available. PMID: 14755268 42: Yang SH, Jaffray E, Senthinathan B, Hay RT, Sharrocks AD. SUMO and transcriptional repression: dynamic interactions between the MAP kinase and SUMO pathways. Cell Cycle. 2003 Nov-Dec;2(6):528-30. PMID: 14504467 43: Hay DC, Beers C, Cameron V, Thomson L, Flitney FW, Hay RT. Activation of NF-kappaB nuclear transcription factor by flow in human endothelial cells. Biochim Biophys Acta. 2003 Sep 23;1642(1-2):33-44. PMID: 12972291 44: Tatham MH, Kim S, Yu B, Jaffray E, Song J, Zheng J, Rodriguez MS, Hay RT, Chen Y. Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation. Biochemistry. 2003 Aug 26;42(33):9959-69. PMID: 12924945 45: Yang SH, Jaffray E, Hay RT, Sharrocks AD. Dynamic interplay of the SUMO and ERK pathways in regulating Elk-1 transcriptional activity. Mol Cell. 2003 Jul;12(1):63-74. PMID: 12887893 46: Liu H, Naismith JH, Hay RT. Adenovirus DNA replication. Curr Top Microbiol Immunol. 2003;272:131-64. PMID: 12747549 *47: Mendoza HM, Shen LN, Botting C, Lewis A, Chen J, Ink B, Hay RT. NEDP1, a highly conserved cysteine protease that deNEDDylates Cullins. J Biol Chem. 2003 Jul 11;278(28):25637-43. Epub 2003 May 1. PMID: 12730221 *48: Girdwood D, Bumpass D, Vaughan OA, Thain A, Anderson LA, Snowden AW, Garcia-Wilson E, Perkins ND, Hay RT. P300 transcriptional repression is mediated by SUMO modification. Mol Cell. 2003 Apr;11(4):1043-54. PMID: 12718889 49: Tatham MH, Chen Y, Hay RT. Role of two residues proximal to the active site of Ubc9 in substrate recognition by the Ubc9.SUMO-1 thiolester complex. Biochemistry. 2003 Mar 25;42(11):3168-79. PMID: 12641448 50: Lang V, Janzen J, Fischer GZ, Soneji Y, Beinke S, Salmeron A, Allen H, Hay RT, Ben-Neriah Y, Ley SC. betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932. Mol Cell Biol. 2003 Jan;23(1):402-13. PMID: 12482991 51: Xirodimas DP, Chisholm J, Desterro JM, Lane DP, Hay RT. P14ARF promotes accumulation of SUMO-1 conjugated (H)Mdm2. FEBS Lett. 2002 Sep 25;528(1-3):207-11. PMID: 12297306 52: Fu M, Wang C, Wang J, Zhang X, Sakamaki T, Yeung YG, Chang C, Hopp T, Fuqua SA, Jaffray E, Hay RT, Palvimo JJ, Janne OA, Pestell RG. Androgen receptor acetylation governs trans activation and MEKK1-induced apoptosis without affecting in vitro sumoylation and trans-repression function. Mol Cell Biol. 2002 May;22(10):3373-88. PMID: 11971970 53: Lin D, Tatham MH, Yu B, Kim S, Hay RT, Chen Y. Identification of a substrate recognition site on Ubc9. J Biol Chem. 2002 Jun 14;277(24):21740-8. PMID: 11877416 54: Fujihara S, Ward C, Dransfield I, Hay RT, Uings IJ, Hayes B, Farrow SN, Haslett C, Rossi AG. Inhibition of nuclear factor-kappaB activation un-masks the ability of TNF-alpha to induce human eosinophil apoptosis. Eur J Immunol. 2002 Feb;32(2):457-66. PMID: 11813164 55: Botting CH, Hay RT. Role of conserved residues in the activity of adenovirus preterminal protein. J Gen Virol. 2001 Aug;82(Pt 8):1917-27. PMID: 11457998 *56: Tatham MH, Jaffray E, Vaughan OA, Desterro JM, Botting CH, Naismith JH, Hay RT. Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9. J Biol Chem. 2001 Sep 21;276(38):35368-74. PMID: 11451954 57: Hay RT. Protein modification by SUMO. 58: Hay DC, Kemp GD, Dargemont C, Hay RT. Interaction between hnRNPA1 and IkappaBalpha is required for maximal activation of NF-kappaB-dependent transcription. Mol Cell Biol. 2001 May;21(10):3482-90. PMID: 11313474 59: Seeler JS, Marchio A, Losson R, Desterro JM, Hay RT, Chambon P, Dejean A. Common properties of nuclear body protein SP100 and TIF1alpha chromatin factor: role of SUMO modification. Mol Cell Biol. 2001 May;21(10):3314-24. PMID: 11313457 *60: Rodriguez MS, Dargemont C, Hay RT. SUMO-1 conjugation in vivo requires both a consensus modification motif and nuclear targeting. J Biol Chem. 2001 Apr 20;276(16):12654-9. PMID: 11124955 61: Liu H, Naismith JH, Hay RT. Identification of conserved residues contributing to the activities of adenovirus DNA polymerase. J Virol. 2000 Dec;74(24):11681-9. PMID: 11090167 *62: Rodriguez MS, Desterro JM, Lain S, Lane DP, Hay RT. Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation. Mol Cell Biol. 2000 Nov;20(22):8458-67. PMID: 11046142 63: Desterro JM, Rodriguez MS, Hay RT. Regulation of transcription factors by protein degradation. Cell Mol Life Sci. 2000 Aug;57(8-9):1207-19. PMID: 11028913 64: Jimenez LA, Thompson J, Brown DA, Rahman I, Antonicelli F, Duffin R, Drost EM, Hay RT, Donaldson K, MacNee W. Activation of NF-kappaB by PM(10) occurs via an iron-mediated mechanism in the absence of IkappaB degradation. Toxicol Appl Pharmacol. 2000 Jul 15;166(2):101-10. PMID: 10896851 65: Midgley CA, Desterro JM, Saville MK, Howard S, Sparks A, Hay RT, Lane DP. An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo. Oncogene. 2000 May 4;19(19):2312-23. PMID: 10822382 66: Clarkson RW, Heeley JL, Chapman R, Aillet F, Hay RT, Wyllie A, Watson CJ. NF-kappaB inhibits apoptosis in murine mammary epithelia. J Biol Chem. 2000 Apr 28;275(17):12737-42. PMID: 10777569 67: Middleton G, Hamanoue M, Enokido Y, Wyatt S, Pennica D, Jaffray E, Hay RT, Davies AM. Cytokine-induced nuclear factor kappa B activation promotes the survival of developing neurons. J Cell Biol. 2000 Jan 24;148(2):325-32. PMID: 10648565 68: Hay RT, Vuillard L, Desterro JM, Rodriguez MS. Control of NF-kappa B transcriptional activation by signal induced proteolysis of I kappa B alpha. Philos Trans R Soc Lond B Biol Sci. 1999 Sep 29;354(1389):1601-9. Review. PMID: 10582246 *69: Rodriguez MS, Desterro JM, Lain S, Midgley CA, Lane DP, Hay RT. SUMO-1 modification activates the transcriptional response of p53. EMBO J. 1999 Nov 15;18(22):6455-61. PMID: 10562557 70: Elsharkawy AM, Wright MC, Hay RT, Arthur MJ, Hughes T, Bahr MJ, Degitz K, Mann DA. Persistent activation of nuclear factor-kappaB in cultured rat hepatic stellate cells involves the induction of potentially novel Rel like factors and prolonged changes in the expression of IkappaB family proteins. 71: Vuillard L, Nicholson J, Hay RT. A complex containing betaTrCP recruits Cdc34 to catalyse ubiquitination of IkappaBalpha. FEBS Lett. 1999 Jul 23;455(3):311-4. PMID: 10437795 72: Hamanoue M, Middleton G, Wyatt S, Jaffray E, Hay RT, Davies AM. p75-mediated NF-kappaB activation enhances the survival response of developing sensory neurons to nerve growth factor. Mol Cell Neurosci. 1999 Jul;14(1):28-40. PMID: 10433815 73: Botting CH, Hay RT. Characterisation of the adenovirus preterminal protein and its interaction with the POU homeodomain of NFIII (Oct-1). Nucleic Acids Res. 1999 Jul 1;27(13):2799-805. PMID: 10373599 *74: Cabannes E, Khan G, Aillet F, Jarrett RF, Hay RT. Mutations in the IkBa gene in Hodgkin's disease suggest a tumour suppressor role for IkappaBalpha. Oncogene. 1999 May 20;18(20):3063-70. PMID: 10340377 75: Baghdiguian S, Martin M, Richard I, Pons F, Astier C, Bourg N, Hay RT, Chemaly R, Halaby G, Loiselet J, Anderson LV, Lopez de Munain A, Fardeau M, Mangeat P, Beckmann JS, Lefranc G. Calpain 3 deficiency is associated with myonuclear apoptosis and profound perturbation of the IkappaB alpha/NF-kappaB pathway in limb-girdle muscular dystrophy type 2A. Nat Med. 1999 May;5(5):503-11. No abstract available. Erratum in: Nat Med 1999 Jul;5(7):849. PMID: 10229226 *76: Desterro JM, Rodriguez MS, Kemp GD, Hay RT. Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1. J Biol Chem. 1999 Apr 9;274(15):10618-24. PMID: 10187858 77: Rodriguez MS, Thompson J, Hay RT, Dargemont C. Nuclear retention of IkappaBalpha protects it from signal-induced degradation and inhibits nuclear factor kappaB transcriptional activation. J Biol Chem. 1999 Mar 26;274(13):9108-15. PMID: 10085161 78: Turpin P, Hay RT, Dargemont C. Characterization of IkappaBalpha nuclear import pathway. J Biol Chem. 1999 Mar 5;274(10):6804-12. PMID: 10037782 79: Duprez E, Saurin AJ, Desterro JM, Lallemand-Breitenbach V, Howe K, Boddy MN, Solomon E, de The H, Hay RT, Freemont PS. SUMO-1 modification of the acute promyelocytic leukaemia protein PML: implications for nuclear localisation. J Cell Sci. 1999 Feb;112 ( Pt 3):381-93. PMID: 9885291 80: Michalopoulos I, Hay RT. Role of the conserved lysine 80 in stabilisation of NF-kappaB p50 DNA binding. Nucleic Acids Res. 1999 Jan 15;27(2):503-9. PMID: 9862972 *81: Desterro JM, Rodriguez MS, Hay RT. SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation. Mol Cell. 1998 Aug;2(2):233-9. PMID: 9734360 82: Wood KM, Roff M, Hay RT. Defective IkappaBalpha in Hodgkin cell lines with constitutively active NF-kappaB. Oncogene. 1998 Apr 23;16(16):2131-9. PMID: 9572494 83: Parker EJ, Botting CH, Webster A, Hay RT. Adenovirus DNA polymerase: domain organisation and interaction with preterminal protein. Nucleic Acids Res. 1998 Mar 1;26(5):1240-7. PMID: 9469832 84: Stark LA, Hay RT. Human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) interacts with Lys-tRNA synthetase: implications for priming of HIV-1 reverse transcription. J Virol. 1998 Apr;72(4):3037-44. PMID: 9525626 *85: Desterro JM, Thomson J, Hay RT. Ubch9 conjugates SUMO but not ubiquitin. FEBS Lett. 1997 Nov 17;417(3):297-300. PMID: 9409737 86: Kroll M, Conconi M, Desterro MJ, Marin A, Thomas D, Friguet B, Hay RT, Virelizier JL, Arenzana-Seisdedos F, Rodriguez MS. The carboxy-terminus of I kappaB alpha determines susceptibility to degradation by the catalytic core of the proteasome. Oncogene. 1997 Oct 9;15(15):1841-50. PMID: 9362451 87: Webster A, Leith IR, Nicholson J, Hounsell J, Hay RT. Role of preterminal protein processing in adenovirus replication. J Virol. 1997 Sep;71(9):6381-9. PMID: 9261355 88: Arenzana-Seisdedos F, Turpin P, Rodriguez M, Thomas D, Hay RT, Virelizier JL, Dargemont C. Nuclear localization of I kappa B alpha promotes active transport of NF-kappa B from the nucleus to the cytoplasm. J Cell Sci. 1997 Feb;110 ( Pt 3):369-78. PMID: 9057089 89: Webster A, Leith IR, Hay RT. Domain organization of the adenovirus preterminal protein. J Virol. 1997 Jan;71(1):539-47. PMID: 8985382 90: Bell S, Matthews JR, Jaffray E, Hay RT. I(kappa)B(gamma) inhibits DNA binding of NF-kappaB p50 homodimers by interacting with residues that contact DNA. Mol Cell Biol. 1996 Nov;16(11):6477-85. PMID: 8887676 91: Monaghan A, Hay RT. Pyridoxal 5'-phosphate inhibition of adenovirus DNA polymerase. J Biol Chem. 1996 Sep 27;271(39):24242-8. PMID: 8798669 92: Lamb JW, Duncan GH, Reavy B, Gildow FE, Mayo MA, Hay RT. Assembly of virus-like particles in insect cells infected with a baculovirus containing a modified coat protein gene of potato leafroll luteovirus. J Gen Virol. 1996 Jul;77 ( Pt 7):1349-58. PMID: 8757974 93: Matthews JR, Botting CH, Panico M, Morris HR, Hay RT. Inhibition of NF-kappaB DNA binding by nitric oxide. 94: Rodriguez MS, Wright J, Thompson J, Thomas D, Baleux F, Virelizier JL, Hay RT, Arenzana-Seisdedos F. Identification of lysine residues required for signal-induced ubiquitination and degradation of I kappa B-alpha in vivo. Oncogene. 1996 Jun 6;12(11):2425-35. PMID: 8649784 95: Roff M, Thompson J, Rodriguez MS, Jacque JM, Baleux F, Arenzana-Seisdedos F, Hay RT. Role of IkappaBalpha ubiquitination in signal-induced activation of NFkappaB in vivo. J Biol Chem. 1996 Mar 29;271(13):7844-50. PMID: 8631829 96: Matthews JR, Nicholson J, Jaffray E, Kelly SM, Price NC, Hay RT. Conformational changes induced by DNA binding of NF-kappa B. Nucleic Acids Res. 1995 Sep 11;23(17):3393-402. PMID: 7567448 97: Matthews JR, Hay RT. Regulation of the DNA binding activity of NF-kappa B. *98: Arenzana-Seisdedos F, Thompson J, Rodriguez MS, Bachelerie F, Thomas D, Hay RT. Inducible nuclear expression of newly synthesized I kappa B alpha negatively regulates DNA-binding and transcriptional activities of NF-kappa B. Mol Cell Biol. 1995 May;15(5):2689-96. PMID: 7739549 99: Rodriguez MS, Michalopoulos I, Arenzana-Seisdedos F, Hay RT. Inducible degradation of I kappa B alpha in vitro and in vivo requires the acidic C-terminal domain of the protein. Mol Cell Biol. 1995 May;15(5):2413-9 PMID: 7739525 100: Alcami J, Lain de Lera T, Folgueira L, Pedraza MA, Jacque JM, Bachelerie F, Noriega AR, Hay RT, Harrich D, Gaynor RB, et al. Absolute dependence on kappa B responsive elements for initiation and Tat-mediated amplification of HIV transcription in blood CD4 T lymphocytes. EMBO J. 1995 Apr 3;14(7):1552-60. PMID: 7729429 101: Jaffray E, Wood KM, Hay RT. Domain organization of I kappa B alpha and sites of interaction with NF-kappa B p65. Mol Cell Biol. 1995 Apr;15(4):2166-72. PMID: 7891711 102: Hay RT, Freeman A, Leith I, Monaghan A, Webster A. Molecular interactions during adenovirus DNA replication. Curr Top Microbiol Immunol. 1995;199 ( Pt 2):31-48. PMID: 7555069 103: Webster A, Leith IR, Hay RT. Activation of adenovirus-coded protease and processing of preterminal protein. J Virol. 1994 Nov;68(11):7292-300. PMID: 7933113 104: Diaz-Meco MT, Dominguez I, Sanz L, Dent P, Lozano J, Municio MM, Berra E, Hay RT, Sturgill TW, Moscat J. zeta PKC induces phosphorylation and inactivation of I kappa B-alpha in vitro. EMBO J. 1994 Jun 15;13(12):2842-8. PMID: 8026469 105: Monaghan A, Webster A, Hay RT. Adenovirus DNA binding protein: helix destabilising properties. Nucleic Acids Res. 1994 Mar 11;22(5):742-8. PMID: 8139913 106: Crompton J, Toogood CI, Wallis N, Hay RT. Expression of a foreign epitope on the surface of the adenovirus hexon. J Gen Virol. 1994 Jan;75 ( Pt 1):133-9. PMID: 7509367 107: Mellits KH, Hay RT, Goodbourn S. Proteolytic degradation of MAD3 (I kappa B alpha) and enhanced processing of the NF-kappa B precursor p105 are obligatory steps in the activation of NF-kappa B. Nucleic Acids Res. 1993 Nov 11;21(22):5059-66. PMID: 8255759 108: Hay RT. Control of nuclear factor-kappa B DNA-binding activity by inhibitory proteins containing ankyrin repeats. Biochem Soc Trans. 1993 Nov;21(4):926-30. Review. No abstract available. PMID: 8132095 109: Hay RT, Nicholson J. DNA binding alters the protease susceptibility of the p50 subunit of NF-kappa B. Nucleic Acids Res. 1993 Sep 25;21(19):4592-8. PMID: 8233795 110: Matthews JR, Watson E, Buckley S, Hay RT. Interaction of the C-terminal region of p105 with the nuclear localisation signal of p50 is required for inhibition of NF-kappa B DNA binding activity. Nucleic Acids Res. 1993 Sep 25;21(19):4516-23. PMID: 7694229 111: Matthews JR, Kaszubska W, Turcatti G, Wells TN, Hay RT. Role of cysteine62 in DNA recognition by the P50 subunit of NF-kappa B. Nucleic Acids Res. 1993 Apr 25;21(8):1727-34. PMID: 8493089 112: Webster A, Hay RT, Kemp G. The adenovirus protease is activated by a virus-coded disulphide-linked peptide. Cell. 1993 Jan 15;72(1):97-104. PMID: 8422686 113: Paya CV, Ten RM, Bessia C, Alcami J, Hay RT, Virelizier JL. NF-kappa B-dependent induction of the NF-kappa B p50 subunit gene promoter underlies self-perpetuation of human immunodeficiency virus transcription in monocytic cells. Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7826-30. PMID: 1502202 114: Matthews JR, Wakasugi N, Virelizier JL, Yodoi J, Hay RT. Thioredoxin regulates the DNA binding activity of NF-kappa B by reduction of a disulphide bond involving cysteine 62. Nucleic Acids Res. 1992 Aug 11;20(15):3821-30. PMID: 1508666 115: Toogood CI, Crompton J, Hay RT. Antipeptide antisera define neutralizing epitopes on the adenovirus hexon. J Gen Virol. 1992 Jun;73 ( Pt 6):1429-35. PMID: 1376769 116: Bosher J, Dawson A, Hay RT. Nuclear factor I is specifically targeted to discrete subnuclear sites in adenovirus type 2-infected cells. J Virol. 1992 May;66(5):3140-50. PMID: 1560540 *117: Temperley SM, Hay RT. Recognition of the adenovirus type 2 origin of DNA replication by the virally encoded DNA polymerase and preterminal proteins. EMBO J. 1992 Feb;11(2):761-8. PMID: 1537347 118: Bosher J, Leith IR, Temperley SM, Wells M, Hay RT. The DNA-binding domain of nuclear factor I is sufficient to cooperate with the adenovirus type 2 DNA-binding protein in viral DNA replication. J Gen Virol. 1991 Dec;72 ( Pt 12):2975-80. PMID: 1765770 119: Temperley SM, Burrow CR, Kelly TJ, Hay RT. Identification of two distinct regions within the adenovirus minimal origin of replication that are required for adenovirus type 4 DNA replication in vitro. J Virol. 1991 Sep;65(9):5037-44. PMID: 1870210 120: Temperley SM, Hay RT. Replication of adenovirus type 4 DNA by a purified fraction from infected cells. Nucleic Acids Res. 1991 Jun 25;19(12):3243-9. PMID: 1829516 121: Bosher J, Robinson EC, Hay RT. Interactions between the adenovirus type 2 DNA polymerase and the DNA binding domain of nuclear factor I. New Biol. 1990 Dec;2(12):1083-90. PMID: 2088500 122: Lamb JW, Hay RT. Ribozymes that cleave potato leafroll virus RNA within the coat protein and polymerase genes. J Gen Virol. 1990 Oct;71 ( Pt 10):2257-64. PMID: 2230733 123: Bahner I, Lamb J, Mayo MA, Hay RT. Expression of the genome of potato leafroll virus: readthrough of the coat protein termination codon in vivo. J Gen Virol. 1990 Oct;71 ( Pt 10):2251-6. PMID: 2230732 124: Watson CJ, Hay RT. Expression of adenovirus type 2 DNA polymerase in insect cells infected with a recombinant baculovirus. Nucleic Acids Res. 1990 Mar 11;18(5):1167-73. PMID: 2181402 125: Clark L, Matthews JR, Hay RT. Interaction of enhancer-binding protein EBP1 (NF-kappa B) with the human immunodeficiency virus type 1 enhancer. J Virol. 1990 Mar;64(3):1335-44. PMID: 2406459 126: Leith IR, Hay RT, Russell WC. Adenovirus subviral particles and cores can support limited DNA replication. J Gen Virol. 1989 Dec;70 ( Pt 12):3235-48. PMID: 2607337 127: Toogood CI, Murali R, Burnett RM, Hay RT. *128: Cleat PH, Hay RT. Co-operative interactions between NFI and the adenovirus DNA binding protein at the adenovirus origin of replication. EMBO J. 1989 Jun;8(6):1841-8. PMID: 2767055 129: Clark L, Nicholson J, Hay RT. Enhancer binding protein (EBP1) makes base and backbone contacts over one complete turn of the DNA double helix. J Mol Biol. 1989 Apr 20;206(4):615-26. PMID: 2544731 130: Hay RT, Russell WC. Recognition mechanisms in the synthesis of animal virus DNA. Biochem J. 1989 Feb 15;258(1):3-16. Review. No abstract available. PMID: 2649089 131: Clark L, Hay RT. Sequence requirement for specific interaction of an enhancer binding protein (EBP1) with DNA. Nucleic Acids Res. 1989 Jan 25;17(2):499-516. PMID: 2536920 132: Leith IR, Hay RT, Russell WC. Detection of Z DNA binding proteins in tissue culture cells. Nucleic Acids Res. 1988 Sep 12;16(17):8277-89. PMID: 3419919 133: Toogood CI, Hay RT. DNA sequence of the adenovirus type 41 hexon gene and predicted structure of the protein. J Gen Virol. 1988 Sep;69 ( Pt 9):2291-301. PMID: 3411299 *134: Clark L, Pollock RM, Hay RT. Identification and purification of EBP1: a HeLa cell protein that binds to a region overlapping the 'core' of the SV40 enhancer. Genes Dev. 1988 Aug;2(8):991-1002. PMID: 2844627 135: Harris MP, Hay RT. DNA sequences required for the initiation of adenovirus type 4 DNA replication in vitro. J Mol Biol. 1988 May 5;201(1):57-67. PMID: 3418700 136: Barrett P, Clark L, Hay RT. A cellular protein binds to a conserved sequence in the adenovirus type 2 enhancer. Nucleic Acids Res. 1987 Mar 25;15(6):2719-35. PMID: 3031610 137: Hay RT, Barrett P, Clark L, Harris M. The role of sequence-specific DNA-binding proteins in adenovirus DNA replication. J Cell Sci Suppl. 1987;7:51-65. PMID: 3503889 138: Hay RT, McDougall IM. Viable viruses with deletions in the left inverted terminal repeat define the adenovirus origin of DNA replication. J Gen Virol. 1986 Feb;67 ( Pt 2):321-32. PMID: 3003240 *139: Hay RT. Origin of adenovirus DNA replication. Role of the nuclear factor I binding site in vivo. J Mol Biol. 1985 Nov 5;186(1):129-36. PMID: 4078897 *140: Hay RT. The origin of adenovirus DNA replication: minimal DNA sequence requirement in vivo. EMBO J. 1985 Feb;4(2):421-6. PMID: 4018031 141: Hay RT, Stow ND, McDougall IM. Replication of adenovirus mini-chromosomes. J Mol Biol. 1984 Jun 5;175(4):493-510. PMID: 6737476 142: Hay RT, Hendrickson EA, DePamphilis ML. Sequence specificity for the initiation of RNA-primed simian virus 40 DNA synthesis in vivo. J Mol Biol. 1984 May 15;175(2):131-57. PMID: 6202875 *143: Hay RT, DePamphilis ML. Initiation of SV40 DNA replication in vivo: location and structure of 5' ends of DNA synthesized in the ori region. Cell. 1982 Apr;28(4):767-79. PMID: 6178514 144: Hay RT, Hay J. Characteristics of chromatin preparations from herpes simplex virus infected cells. Biochim Biophys Acta. 1981 Aug 27;655(1):71-81. PMID: 6266485 145: Hay RT, Hay J. Properties of herpesvirus-induced "immediate early" polypeptides. Virology. 1980 Jul 15;104(1):230-4. PMID: 6249025 146: Hay RT, Hay J. Synthesis of herpes simplex virus DNA in preparations of chromatin from infected cell nuclei. J Gen Virol. 1978 Nov;41(2):427-31. PMID: 214524
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