Sponsors

The objective of the work in our laboratory is to determine the function of modification with the Small Ubiquitin-like Modifier (SUMO) in important biological processes. The laboratory utilizes a wide variety of approaches and combines cell, molecular and structural biology. A system wide analysis of SUMO substrates is being conducted using Stable Isotope Labeling with Amino acids in Cell culture (SILAC) and high resolution Orbitrap mass spectrometrs. To identify genes involved in particular pathways we have established whole genome siRNA screening as a collaboration with the High Throughput facility set up by Professor Julie Frearson which has state of the art robotic and data handling infrastructure. RTH is also an honorary member of The Protein Ubiquitination Unit of The Scottish Institute for Cell Signaling (SCILLS) and is part of the RUBICON EU Network of excellence in ubiquitin and ubiquitin-like proteins.

We are part of the Wellcome Trust Centre for Gene Regulation and Expression and our laboratories are housed on the Mezzanine Floor of the Sir James Black Building. Our laboratory consists of 4 bays with bench and office space for 16 researchers, plus a tissue culture facility, hot rooms (37 and 27°C), cold room, radioactive handling suite and direct access to the communal equipment area. Why not take the tour and see the movies of our lab. If you are interested in PhD studies in this area (click here for current projects) please contact Gail Guild (g.guild@dundee.ac.uk).  If you are an experienced and committed researcher and are interested in postdoctoral work in this area please contact Ron Hay directly (r.t.hay@dundee.ac.uk).