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The objective of the work in our laboratory is to establish the role of ubiquitin and ubiquitin-like proteins in important biological processes. We presently have a number of projects investigating the role of SUMO in ubiquitylation pathways, stress responses such as DNA damage and heat-stress, and the chemotherapeutic consequcnes of arsenic therapy. The laboratory utilizes a wide variety of approaches and combines cell, molecular and structural biology with quantitative proteomics. We are continuing to develop both labelled and label-free proteomic methods to monitor protein SUMOylation in cells. Ron Hay is also an honorary member of The MRC Protein Phosphorylation and Ubiquitylation Unit and has established an siRNA screening platform with state of the art robotic and data handling infrastructure to identify genes in the ubiquitin pathway involved in disease processes.

We are part of the Centre for Gene Regulation and Expression and our laboratories are housed on the Mezzanine Floor of the Sir James Black Building. Our laboratory consists of 4 bays with bench and office space for 16 researchers, plus a tissue culture facility, hot rooms (37 and 27°C), cold room, radioactive handling suite and direct access to the communal equipment area. We also have our own Q exactive mass spctrometer housed in the MRC-PPU proteomics facility. Why not take the tour and see the movies of our lab. If you are interested in PhD studies in this area (click here for current projects) please contact Gail Guild (g.guild@dundee.ac.uk).  If you are an experienced and committed researcher and are interested in postdoctoral work in this area please contact Ron Hay directly (r.t.hay@dundee.ac.uk).