Publications

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I. Primary research papers

 

1.      Kawabe, Y., Morio, T., James, J.L., Prescott, A.R., Tanaka, Y.and Schaap, P.(2009) Activated cAMP receptors turn encystation into sporulation. Proc.Nat.Acad.Sci.USA, 106, 7089-7094.

2.      Ritchie, A.V., Van Es, S., Fouquet, C.and Schaap, P.(2008).From drought sensing to developmental control: evolution of cyclic AMP signaling in social amoebas Mol.Biol.Evol.25, 1-10.

3.      Alvarez-Curto, E., Saran, S., Meima, M., Zobel, J., Scott, C., and Schaap, P.(2007).cAMP production by adenylyl cyclase G induces prespore differentiation in Dictyostelium slugs.Development 134, 959-966.

4.      Alvarez-Curto, E., Weening, K.E., and Schaap, P.(2007).Pharmacological profiling of the Dictyostelium adenylate cyclases ACA, ACB and ACG. Biochem.J.401, 309-316.

5.      Meima, M.E., Weening, K.E., and Schaap, P.(2007).Vectors for expression of proteins with single or combinatorial fluorescent protein and tandem affinity purification tags in Dictyostelium.Protein Expr.Purif.53, 283-288.

6.      Schaap, P., Winckler, T., Nelson, M., Alvarez-Curto, E., Elgie, B., Hagiwara, H., Cavender, J., Milano-Curto, A., Rozen, D.E., Dingermann, T., et al.(2006).Molecular phylogeny and evolution of morphology in the social amoebas. Science 314, 661-663.

7.      Alvarez-Curto, E., Rozen, D.E., Ritchie, A.V., Fouquet, C., Baldauf, S.L.and Schaap, P.(2005).Evolutionary origin of cAMP-based chemoattraction in the social amoebae. Proc.Natl.Acad.Sci.USA 102, 6385-6390.

8.      Saran, S.and Schaap, P.(2004).Adenylyl cyclase G is activated by an intramolecular osmosensor. Mol.Biol.Cell 15, 1479-1486.

9.      Darley, C.P., Li, Y., Schaap, P.and McQueen-Mason, S.J.(2003).Expression of a family of expansin-like proteins during the development of Dictyostelium discoideum. FEBS Lett., 546,416-418.

10.    Muhia, D.K., Swales, C.A., Eckstein-Ludwig, U., Saran, S., Polley, S.D., Kelly, J.M., Schaap, P., Krishna, S.and Baker, D.A.(2003) Multiple splice variants encode a novel adenylyl cyclase of possible plastid origin expressed in the sexual stage of the malaria parasite Plasmodium falciparum. J.Biol.Chem. 278, 22014 - 22022.

11.    Araki, T., Tsujioka, M., Abe, T., Fukuzawa, M., Meima, M., Schaap, P., Morio, T., Urushihara, H., Katoh, M., Maeda, M.,Tanaka, Y., Takeuchi, I.and Williams.J.G.(2003).A STAT regulated, stress-induced signalling pathway in Dictyostelium. J.Cell Sci.116, 2907-2915.

12.    Meima M.E., Weening K.E.and Schaap, P.(2003).A novel cAMP-stimulated cAMP phosphodiesterase in Dictyostelium discoideum. J.Biol.Chem. 278, 14356-14362.

13.    Weening, K.E., Verkerke-Van Wijk, I., Thompson, C.R., Kessin, R.H., Podgorski, G.and Schaap, P. (2003). Contrasting activities of the aggregative and late PdsA promoters in Dictyostelium development. Dev.Biol. 255, 373-382.

14.    Meima, M.E., Biondi, R.M.and Schaap, P.(2002) Identification of a novel type of cGMP phosphodiesterase that is defective in the chemotactic stmF mutants. Mol.Biol.Cell.13, 3870-3877.

15.    Segovia, M., Francisco J., Gordillo, L., Schaap, P.and Figueroa, F.L.(2001) Light regulation of cyclic AMP levels in the red macroalga Porphyra leucosticta.J.Photochem.Photobiol. 64, 69-74.

16.    Roelofs, J., Meima, M., Schaap, P., and Van Haastert, P.J.(2001).The Dictyostelium homologue of mammalian soluble adenylyl cyclase encodes a guanylyl cyclase, EMBO J.20, 4341-4348.

17.    Verkerke-van Wijk, I., Fukuzawa, M., Devreotes, P.N., and Schaap, P.(2001).Adenylyl cyclase A expression is tip-specific in Dictyostelium slugs and directs StatA nuclear translocation and CudA gene expression, Dev.Biol. 234, 151-60.

18.    Carucci, D.J., Witney, A.A., Warhurst, D.C., Muhia, D.K., Schaap, P., Meima, M., Li, J.-L., Taylor, M.C., Kelly, J.M., Baker, D.A.(2000) Guanylyl cyclase activity associated with putative bifunctional integral membrane proteins in Plasmodium falciparum. J.Biol.Chem.275, 22147-22156.

19.    Taylor, M.C., Muhia, D., Baker, D.A., Mondragon, A., Schaap, P.and Kelly, J.M.(1999).Trypanosoma cruzi adenylyl cyclase is encoded by a complex multigene family. Mol.Biochem.Parasitol.104, 205-217.

20.    Meima, M.E.and Schaap, P.(1999).Fingerprinting of adenylyl cyclase activities during Dictyostelium development indicates a dominant role for adenylyl cyclase B in terminal differentiation. Dev.Biol. 212, 182-190.

21.    Mohanti, S., Jermyn, K.A., Early, A., Kawata, T., Aubry, L., Ceccarelli, A., Schaap, P., Williams, J.G., Firtel, R.A. (1999).Evidence that the Dictyostelium Dd-STATa protein is a repressor that regulates commitment to stalk cell differentiation and is also required for efficient chemotaxis. Development 126, 3391-3405.

22.    Virdy, K.J., Sands, T.W., Kopko, S.H., Van Es, S., Meima, M.E., Schaap, P.and Cotter, D.A.(1999).High cAMP in spores of Dictyostelium discoideum: Association with spore dormancy and inhibition of germination. Microbiology 145, 1883-1890.

23.    Kim, H.-J., Chang, W-T., Meima, M., Gross, J.D.and Schaap, P.(1998).A novel adenylyl cyclase activity detected in rapidly developing mutants of Dictyostelium. J.Biol.Chem.273, 30859-30862.

24.    Jin,T., Soede, R.D.M., Liu, J., Kimmel, A.R., Devreotes, P.N.and Schaap, P.(1998).Temperature-sensitive Gß mutants discriminate between G-protein dependent and G-protein independent gene regulation and signaling mediated by serpentine receptors. EMBO J.17, 5076-5984.

25.    Verkerke- Van Wijk, I., Kim, J-Y., Brandt, R., Devreotes, P.N.and Schaap, P.(1998).Functional promiscuity of gene regulation by the Dictyostelium cAMP receptors cAR1, cAR2 and cAR3. Mol.Cell.Biol.18, 5744-5749.

26.    Verkerke-Van Wijk, I., Brandt, R., Bosman, L.and Schaap, P.(1998).Two distinct signaling pathways mediate DIF induction of prestalk gene expression in Dictyostelium. Exp.Cell Res.245, 179-185.

27.    Kim, J.Y., Soede, R., Schaap, P., Valkema, R., Borleis, A., Van Haastert, P.J.M., Devreotes, P.N.and Hereld, D.(1997).Phosphorylation of chemoattractant receptors is not essential for chemotaxis or termination of G-protein-mediated responses. J.Biol.Chem. 272, 27313-27318.

28.    Van Es, S., Kooistra, R.A.and Schaap, P.(1997).Two ras genes in Dictyostelium minutum show high sequence homology but different developmental regulation from Dictyostelium discoideum rasD and rasG genes. Gene 187, 93-97.

29.    Schaap, P., Nebl, T and Fisher, P.R.(1996) A slow sustained increase in cytosolic Ca2+ levels mediates stalk gene induction by differentiation inducing factor in Dictyostelium. EMBO J.15, 5177-5183.

30.    Van Es, S., Virdy, K.J., Pitt, G.S., Meima, M., Sands, T.W., Devreotes, P.N., Cotter, D.A.and Schaap, P. (1996). Adenylyl cyclase G, an osmosensor controling germination of Dictyostelium spores. J.Biol.Chem.271, 23623-23625.

31.    Soede, R.D.M., Hopper, N.A., Williams, J.G.and Schaap, P.(1996).Extracellular cAMP depletion triggers stalk gene expression in Dictyostelium; disparities in dose dependency and developmental timing indicate that prespore induction and stalk repression by cAMP are mediated by separate signaling pathways. Dev.Biol.177, 152-159.

32.    Schaap, P., Tang, Y.and Othmer, H.G.(1996) A model for pattern formation in Dictyostelium discoideum. Differentiation 60, 1-16.

33.    Schaap, P., Brandt, R.and Van Es, S.(1995).Regulation of Dictyostelium adenylyl cyclases by morphogen-induced modulation of cytosolic pH or Ca2+ levels. Dev.Biol.168, 179-188.

34.    Schulkes, C., Verkerke-van Wijk, W.and Schaap, P.(1995).Transformation with vectors harboring the NEOR selection marker induces germination-specific adenylylcyclase activity in Dictyostelium cells. Exp.Cell Res. 220, 505-508.

35.    Schulkes, C.and Schaap, P.(1995).cAMP-dependent protein kinase activity is essential for preaggregative gene expression in Dictyostelium. FEBS Lett. 368, 381-384.

36.    Pitt, G.S., Brandt, R., Lin, K.C., Devreotes, P.N.and Schaap, P.(1994) Extracellular cAMP is sufficient to restore developmental gene expression and morphogenesis in Dictyostelium cells lacking the aggregation adenylyl cyclase (ACA). Genes & Development 7, 2172-2180.

37.    Van Es, S, Nieuwenhuizen B.W., Lenouvel, F., Van Deursum, E.M.and Schaap, P.(1994).Universal signals control slime mold stalk formation. Proc.Natl.Acad.Sci.USA 91, 8219-8223.

38.    Soede, R.D.M, Insall, R.H.Devreotes, P.N.and Schaap, P.(1994).Extracellular cAMP can restore development in Dictyostelium cells lacking one, but not two subtypes of early cAMP receptors (cARs). Development 120, 1997-2002.

39.    Insall, R.H., Soede.R.D.M., Schaap, P.and Devreotes, P.N.(1994).Two cAMP receptors activate common signaling pathways in Dictyostelium. Mol.Biol.Cell 5, 703-711.

40.    Van Es, S., Hodgkinson, S., Schaap, P.and Kay, R.R.(1994).Metabolic pathways for differentiation inducing factor-1 and their regulation are conserved between closely related Dictyostelium species, but not between distant members of the family. Differentiation, 58, 95-100.

41.    Schaap, P., Van Ments-Cohen, M., Soede, R.D.M., Brandt, R., Firtel, R.A., Dostmann, W., Genieser, H.-G., Jastorff, B.and Van Haastert, P.J.M.(1993) Cell-permeable non-hydrolysable cAMP derivatives as tools for analysis of signaling pathways controlling gene regulation in Dictyostelium. J.Biol.Chem. 268, 6323-6331.

42.    Peters, D.J.M., Snaar-Jagalska, B.E.,Van Haastert, P.J.M.and Schaap, P.(1992).Lithium, an inhibitor of cAMP-induced inositol 1,4,5-trisphosphate accumulation in Dictyostelium discoideum, inhibits activation of G proteins, reduces activation of adenylyl cyclase, but potentiates activation of guanylyl cyclase by cAMP. Eur.J.Biochem. 209, 299-304.

43.    Van Haastert, P.J.M., Wang, M., Bominaar, A.A., Devreotes, P.N.and Schaap, P.(1992) cAMP-induced desensization of surface cAMP receptors in Dictyostelium: Different second messengers mediate receptor phosphorylation, loss of ligand binding, degradation of receptor and reduction of receptor mRNA levels. Mol.Biol.Cell. 3, 603-612.

44.    Van Ments-Cohen, M., Genieser, H-G., Jastorff, B., Van Haastert, P.J.M.and Schaap, P.(1991).Kinetics and nucleotide specificity of a surface cAMP binding site, which is not down-regulated by cAMP. FEMS Microbiol. Lett. 82, 9-14.

45.    Peters, D.J.M., Bominaar, A.A., Snaar-Jagalska, B.E., Brandt, R., Van Haastert, P.J.M., Ceccarelli, A., Williams, J.G.and Schaap, P.(1991) Selective induction of gene expression and second messenger accumulation in Dictyostelium discoideum by the partial chemotactic antagonist 8-p-chlorophenylthio-cAMP. Proc.Natl.Acad.Sci. USA. 88, 9219-9223.

46.    Bominaar, A.A., Kesbeke, F., Snaar-Jagalska, B.E., Peters, D.J.M., Schaap, P.and Van Haastert, P.J.M.(1991) Aberrant chemotaxis and differentiation in Dictyostelium mutant fgdC with a defective regulation of receptor stimulated phosphoinositidase C. J.Cell Sci. 100, 825-831.

47.    Wang, M., Roelfsema, J.H., Williams, J.G.and Schaap, P.(1990).Cytoplasmic acidification facilitates but does not mediate DIF-induced prestalk gene expression in Dictyostelium discoideum. Dev.Biol.140, 182-188.

48.    Wang, M.and Schaap, P.(1989).Ammonia depletion and DIF trigger stalk cell differentiation in intact Dictyostelium discoideum slugs. Development 105, 569-574.

49.    Van Lookeren Campagne, M.M., Aerts, R.J., Spek, W., Firtel, R.A.and Schaap, P.(1989).Cyclic-AMP-induced elevation of intracellular pH precedes, but does not mediate, the induction of prespore differentiation in Dictyostelium discoideum. Development 105, 401-406.

50.    Peters, D.J.M., Van Lookeren Campagne, M.M., Van Haastert, P.J.M., Spek, W.and Schaap, P.(1989).Lithium ions induce prestalk-associated gene expression and inhibit prespore gene expression in Dictyostelium discoideum. J.Cell Sci. 93, 205-210.

51.    Wang, M., Aerts, R.J., Spek, W.and Schaap, P.(1988).Cell cycle phase in Dictyostelium discoideum is correlated with the expression of cyclic AMP production, detection, and degradation. Dev.Biol. 125, 410-416.

52.    Spek, W., Van Drunen, K., Van Eijk, R.and Schaap, P.(1988).Opposite effects of adenosine on two types of cAMP-induced gene expression in Dictyostelium indicate the involvement of at least two different intracellular pathways for the transduction of cAMP signals. FEBS Lett. 228, 231-234.

53.    Wang, M., Van Driel, R.and Schaap, P.(1988).Cyclic AMP-phosphodiesterase induces dedifferentiation of prespore cells in Dictyostelium discoideum slugs: evidence that cyclic AMP is the morphogenetic signal for prespore differentiation. Development 103, 611-618.

54.    Van Lookeren Campagne, M.M., Wang, M., Spek, W., Peters, D.and Schaap, P.(1988).Lithium respecifies cyclic-AMP induced cell-type specific gene expression in Dictyostelium. Dev.Gen. 9, 589-596.

55.    Wang, M., Van Haastert, P.J.M., Devreotes, P.N.and Schaap, P.(1988).Localization of chemoattractant receptors on Dictyostelium discoideum cells during aggregation and down-regulation. Dev.Biol.128, 72-77.

56.    Schaap, P., Van Lookeren Campagne, M.M., Van Driel, R., Spek, W., Van Haastert, P.J.M.and Pinas, J.(1986).Postaggregative differentiation induction by cyclic AMP in Dictyostelium: Intracellular transduction pathway and requirement for additional stimuli. Dev.Biol.118, 52-63.

57.    Wang, M., Van Haastert, P.J.M.and Schaap, P.(1986).Multiple effects of differentiation-inducing factor on prespore differentiation and cyclic-AMP signal transduction in Dictyostelium. Differentiation 33, 24-28.

58.    Kesbeke, F., Van Haastert, P.J.M.and Schaap, P.(1986).Cyclic AMP relay and cyclic AMP-induced cyclic GMP accumulation during development of Dictyostelium discoideum. FEMS Microbiol.Lett. 34, 85-89.

59.    Van Lookeren Campagne, M.M., Schaap, P.and Van Haastert, P.J.M.(1986).Specificity of adenosine inhibition of cAMP-induced responses in Dictyostelium resembles that of the P site of higher organisms. Dev.Biol.117, 245-251.

60.    Schaap, P.and Wang, M.(1986).Interactions between adenosine and oscillatory cAMP signaling regulate size and pattern in Dictyostelium. Cell 45, 137.

61.    Schaap, P.(1985).cAMP relay during early culmination of Dictyostelium minutum. Differentiation 28, 205-208.

62.    Schaap, P.and Van Driel, R.(1985).Induction of post-aggregative differentiation in Dictyostelium discoideum by cAMP.Evidence for involvement of the cell surface cAMP receptor. Exp.Cell Res.159, 388-398.

63.    Schaap, P., Pinas, J.E.and Wang, M.(1985).Patterns of cell differentiation in several cellular slime mold species. Dev.Biol. 111, 51-61.

64.    Schaap, P.and Wang, M.(1985).cAMP induces a transient elevation of cGMP levels during early culmination of Dictyostelium minutum. Cell Differ.16, 29-33.

65.    Wang, M.and Schaap, P.(1985).Correlations between tip dominance, prestalk/prespore pattern, and cAMP-relay efficiency in slugs of Dictyostelium discoideum. Differentiation 30, 7-14.

66.    Schaap, P., Konijn, T.M.and Van Haastert, P.J.M.(1984).cAMP pulses coordinate morphogenetic movement during fruiting body formation of Dictyostelium minutum. Proc.Natl.Acad.Sci.USA 81, 2122-2126.

67.    Schaap, P.and Spek, W.(1984).Cyclic-AMP binding to the cell surface during development of Dictyostelium discoideum. Differentiation 27, 83-87.

68.    Schaap, P.and Wang, M.(1984).The possible involvement of oscillatory cAMP signaling in multicellular morphogenesis of the cellular slime molds. Dev.Biol.105, 470-478.

69.    Schaap, P., Van der Molen, L.and Konijn, T.M.(1983).The organisation of fruiting body formation in Dictyostelium minutum. Cell Differ.12, 287-297.

70.    Schaap, P.(1983).Quantitative analysis of the spatial distribution of ultrastructural differentiation markers during development of Dictyostelium discoideum. Wilhelm Roux's Arch.Dev.Biol.192, 86-94.

71.    Schaap, P., Van der Molen, L.and Konijn T.M.(1982).Early recognition of prespore differentiation in Dictyostelium discoideum and its significance for models on pattern formation. Differentiation 22, 1-5.

72.    Schaap, P., Van der Molen, L.and Konijn, T.M.(1981).Development of the simple cellular slime mold Dictyostelium minutum. Dev.Biol. 85, 171-179.

73.    Schaap, P., Van der Molen, L.and Konijn, T.M.(1981).The vacuolar apparatus of the simple cellular slime mold Dictyostelium minutum. Biol.Cell 41, 133-142.

74.    Schaap, P.and Van der Molen, L.(1980).Membrane modulations during development of Dictyostelium minutum. Electron Microscopy 2, 42-43.

75.    Braggaar-Schaap, P.(1979).A sensitive method for assaying acetylcholine synthesis in human and frog skeletal muscle. J.Neurochem. 33, 389-392.

 

II.Invited reviews and book chapters

 

76.    Kawabe, Y., Alvarez-Curto, E., Ritchie, A.V.and Schaap, P.(2009).The evolution of morphogenetic signalling in social amoebae.In: Evolutionary Biology: Concept, Modeling, and Application, Ed.P.Pontarotti.Springer Verlag, Heidelberg.Pp 91-107.

77.    Scott, C and Schaap, P.(2009).Dictyostelium.In: Encyclopedia of Microbiology, Ed.M.Schaechter. Elsevier, Oxford.pp.606-616.

78.    Schaap, P.(2007).The evolution of size and pattern in the social amoebas. BioEssays 29, 635-644.

79.    Schaap, P.(2006).The Dictyostelium genome - blueprint for a multicellular protist.In: Genome evolution in eukaryotic microbes.Eds.L.A.Katz and D.Bhattacharya, Oxford University Press, pp.214-226.

80.    Schaap, P.(2005) Guanylyl cyclases across the tree of life.Frontiers in Bioscience 10, 1495-1498.

81.    Schaap, P.(2004).Non-metazoan class III nucleotidyl cyclases: Novel forms and functions. IUBMB Life 56, 527-528.

82.    Nebl, T., Kotsifas, M., Schaap, P.and Fisher, P.R.(2002).Multiple signaling pathways connect chemoattractant receptors and calcium channels in Dictyostelium. J.Muscle Res.Cell Mot. 23, 853-865.

83.    Saran, S., Meima, M.E., Alvarez-Curto, E., Weening, K.E., Rozen.D.E.and Schaap, P.(2002).cAMP signaling in Dictyostelium.Complexity of cAMP synthesis, degradation and detection. J.Muscle Res.Cell Mot. 23, 793-802.

84.    Schaap, P.(2002) Survival by cAMP in social amoebae: an intersection between eukaryotic and prokaryotic signaling systems. Microbiology Today, 29, 136-138.

85.    Alvarez-Curto, E., Meima, M.E.and Schaap, P.(2001) Expression and role of adenylyl cyclases during late development in Dictyostelium discoideum. Int.J.Dev.Biol. 45, S147-S148.

86.    Meima, M.E.and Schaap, P.(1999).Dictyostelium development:socializing through cAMP. Seminars Cell Dev.Biol. 10, 567-576.

87.    Schaap, P.and Williams, J.G.(1999).Cell communication in Dictyostelium.In: Development, Genetics, Epigenetics and Environmental regulation.(V.E.A.Russo, D.J.Cove, L.G.Edgar, R.Jaenisch, F.Salamini, eds.) Springer-Verlag, Berlin.pp.83-97.

88.    Othmer, H.G.and Schaap, P.(1998).Oscillatory cAMP signaling in the development of Dictyostelium discoideum. Comments in Theoretical Biology 5, 175-282.

89.    Verkerke-Van Wijk, I.and Schaap, P.(1997).cAMP, a signal for survival.In: Dictyostelium - A Model System for Cell and Developmental Biology.Y.Maeda, K.Inouye and I.Takeuchi, editors.Universal Academy Press Inc.Tokyo, pp.145-162.

90.    Reymond, C.D., Schaap, P., Veron, M.and Williams, J.G. (1995).Dual role of cAMP during Dictyostelium development. Experientia 51, 1166-1174.

91.    Schaap, P.and Wang M.(1993).Four signals to shape a slime mold.In: Experimental and Theoretical advances in Biological Pattern Formation.eds.H.G.Othmer, P.K.Maini and J.D.Murray.NATO ASI series, Plenum Press, New York.pp 301-318.

92.    Soede, R.D.M., Peters, D.J.M., Jastorff, B., Van Haastert, P.J.M.and Schaap, P.(1993) A pharmacological approach to identify hormone signaling pathways controlling gene regulation in Dictyostelium.In: New developments in lipid-protein interactions and receptor function.eds.Wirtz, K.W.A.and Gustafsen, J.A.NATO ASI series.

93.    Schaap, P., Peters, D.J.M., Haribabu, B and Dottin, R.P.(1993) Gene regulation by hormone-like signals in Dictyostelium.in: Signal Transduction: prokaryotic and simple eukaryotic systems. eds.J.Kurjan and B.L.Taylor. Academic Press, San Diego, pp 353-376.

94.    Schaap, P.(1991).Intercellular interactions during Dictyostelium development. In Microbial cell-cell interactions. ed.M.Dworkin. American Society for Microbiology, Washington.pp 147-178.

95.    Peters, D.J.M., Cammans, M., Smit, S., Spek, W., Van Lookeren Campagne, M.M.and Schaap, P.(1991).Control of cAMP-induced gene expression by divergent signal transduction pathways. Dev.Gen.12, 25-34.

96.    Schaap, P.(1986).Regulation of size and pattern in the cellular slime molds. Differentiation 33, 1-16.

97.     Polak, R.L., Molenaar, P.C.and Braggaar-Schaap, P.(1977).Regulation of acetylcholine synthesis in rat brain.In: Cholinergic Mechanisms and Psychopharmacology   (Jenden D.J., ed.) Pp.511-524.Plenum Press, New York.

 

 

 

 

 

 

 

 

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Last updated: 04/02/10.