Claire Scott

Scott, C and Schaap, P.(2009).Dictyostelium.In: Encyclopedia of Microbiology, Ed.M.Schaechter. Elsevier, Oxford.pp.606-616.

Karin E. Weening

Ph.D. student

Maria Romeralo

Allyson V. Ritchie

Ph.D. Student

Elisa Alvarez-Curto

Ph.D. student

Marcel Meima

Ph.D. student

Meima M.E., Weening K.E. and Schaap, P. (2003). A novel cAMP-stimulated cAMP phosphodiesterase in Dictyostelium discoideum. J. Biol. Chem. 278, 14356-14362.

Araki, T., Tsujioka, M., Abe, T., Fukuzawa, M., Meima, M., Schaap, P., Morio, T., Urushihara, H., Katoh, M., Maeda, M.,Tanaka, Y., Takeuchi, I. and Williams. J.G. (2003). A STAT regulated, stress-induced signalling pathway in Dictyostelium. J. Cell Sci. 116, 2907-2915

Meima, M.E., Biondi, R.M. and Schaap, P. (2002) Identification of a novel type of cGMP phosphodiesterase that is defective in the chemotactic stmF mutants. Mol. Biol. Cell. 13, 3870-3877.

Saran, S., Meima, M.E., Alvarez-Curto, E., Weening, K.E., Rozen. D.E. and Schaap, P. (2002). cAMP signaling in Dictyostelium. Complexity of cAMP synthesis, degradation and detection. J. Muscle Res. Cell Mot. 23, 793-802.

Roelofs, J., Meima, M., Schaap, P., and Van Haastert, P. J. (2001). The Dictyostelium homologue of mammalian soluble adenylyl cyclase encodes a guanylyl cyclase, EMBO J. 20, 4341-4348.

Carucci, D.J., Witney, A.A., Warhurst, D.C., Muhia, D.K., Schaap, P., Meima, M., Li, J.-L., Taylor, M.C., Kelly, J.M., Baker, D.A. (2000) Guanylyl cyclase activity associated with putative bifunctional integral membrane proteins in Plasmodium falciparum. J. Biol. Chem. 275, 22147-22156.

Meima, M.E. and Schaap, P. (1999). Dictyostelium development – socializing through cAMP. Seminars Cell Dev. Biol. 10, 567-576.

Meima, M.E. and Schaap, P. (1999). Fingerprinting of adenylyl cyclase activities during Dictyostelium development indicates a dominant role for adenylyl cyclase B in terminal differentiation. Dev. Biol. 212, 182-190.

Shweta Saran

Postdoctoral Researcher

Saran, S. and Schaap, P. (2004). Adenylyl cyclase G is activated by an intramolecular osmosensor. Mol. Biol. Cell 15, 1479-1486.

Muhia, D.K., Swales, C.A., Eckstein-Ludwig, U., Saran, S., Polley, S.D., Kelly, J.M., Schaap, P., Krishna, S. and Baker, D.A. (2003) Multiple splice variants encode a novel adenylyl cyclase of possible plastid origin expressed in the sexual stage of the malaria parasite Plasmodium falciparum. J. Biol. Chem. 278, 22014 - 22022.

Daniel E. Rozen

Postdoctoral Researcher

Schaap, P., Winckler, T., Nelson, M., Alvarez-Curto, E., Elgie, B., Hagiwara, H., Cavender, J., Milano-Curto, A., Rozen, D.E., Dingermann, T., et al.(2006).Molecular phylogeny and evolution of morphology in the social amoebas.Science 314, 661-663.

Alvarez-Curto, E., Rozen, D.E., Ritchie, A.V., Fouquet, C., Baldauf, S.L. and Schaap. P. (2005). The evolution of cAMP-based chemoattraction in the Dictyostelids. Proc. Natl. Acad. Sci. USA 102, 6385-6390.

Irene Verkerke-Van Wijk

Ph.D. student

Weening, K.E., Verkerke-Van Wijk, I., Thompson, C.R., Kessin, R.H., Podgorski, G. and Schaap, P. (2003). Contrasting activities of the aggregative and late PdsA promoters in Dictyostelium development. Dev. Biol. 255, 373-382.

Verkerke-van Wijk, I., Fukuzawa, M., Devreotes, P. N., and Schaap, P. (2001). Adenylyl cyclase A expression is tip-specific in Dictyostelium slugs and directs StatA nuclear translocation and CudA gene expression, Dev. Biol. 234, 151-60.

Verkerke- Van Wijk, I., Kim, J-Y., Brandt, R., Devreotes, P.N. and Schaap, P. (1998). Functional promiscuity of gene regulation by the Dictyostelium cAMP receptors cAR1, cAR2 and cAR3. Mol. Cell. Biol. 18, 5744-5749.

Verkerke-Van Wijk, I., Brandt, R., Bosman, L. and Schaap, P. (1998). Two distinct signaling pathways mediate DIF induction of prestalk gene expression in Dictyostelium. Exp. Cell Res. 245, 179-185.

Verkerke-Van Wijk, I. and Schaap, P. (1997). cAMP, a signal for survival. In: Dictyostelium - A Model System for Cell and Developmental Biology. Y. Maeda, K. Inouye and I. Takeuchi, editors. Universal Academy Press Inc. Tokyo, pp. 145-162.

Ron D.M. Soede

Ph.D. student

Jin,T., Soede, R.D.M., Liu, J., Kimmel, A.R., Devreotes, P.N. and Schaap, P. (1998). Temperature-sensitive Gß mutants discriminate between G-protein dependent and G-protein independent gene regulation and signaling mediated by serpentine receptors. EMBO J. 17, 5076-5984.

Kim, J.Y., Soede, R., Schaap, P., Valkema, R., Borleis, A., Van Haastert, P.J.M., Devreotes, P.N. and Hereld, D. (1997). Phosphorylation of chemoattractant receptors is not essential for chemotaxis or termination of G-protein-mediated responses. J. Biol. Chem. 272, 27313-27318.

Soede, R.D.M., Hopper, N.A., Williams, J.G. and Schaap, P. (1996). Extracellular cAMP depletion triggers stalk gene expression in Dictyostelium; disparities in dose dependency and developmental timing indicate that prespore induction and stalk repression by cAMP are mediated by separate signaling pathways. Dev. Biol. 177, 152-159.

Soede, R.D.M, Insall, R.H. Devreotes, P.N. and Schaap, P. (1994). Extracellular cAMP can restore development in Dictyostelium cells lacking one, but not two subtypes of early cAMP receptors (cARs). Development 120, 1997-2002.

Insall, R.H., Soede. R.D.M., Schaap, P. and Devreotes, P.N. (1994). Two cAMP receptors activate common signaling pathways in Dictyostelium. Mol. Biol. Cell 5, 703-711.

Schaap, P., Van Ments-Cohen, M., Soede, R.D.M., Brandt, R., Firtel, R.A., Dostmann, W., Genieser, H.-G., Jastorff, B. and Van Haastert, P.J.M. (1993) Cell-permeable non-hydrolysable cAMP derivatives as tools for analysis of signaling pathways controlling gene regulation in Dictyostelium. J. Biol. Chem. 268, 6323-6331.

Soede, R.D.M., Peters, D.J.M., Jastorff, B., Van Haastert, P.J.M. and Schaap, P. (1993) A pharmacological approach to identify hormone signaling pathways controlling gene regulation in Dictyostelium. In: New developments in lipid-protein interactions and receptor function. eds. Wirtz, K.W.A. and Gustafsen, J.A. NATO ASI series.

Saskia van Es

Ph.D. student

Virdy, K.J., Sands, T.W., Kopko, S.H., Van Es, S., Meima, M.E., Schaap, P. and Cotter, D.A. (1999). High cAMP in spores of Dictyostelium discoideum: Association with spore dormancy and inhibition of germination. Microbiology 145, 1883-1890.

Van Es, S., Kooistra, R.A. and Schaap, P. (1997). Two ras genes in Dictyostelium minutum show high sequence homology but different developmental regulation from Dictyostelium discoideum rasD and rasG genes. Gene 187, 93-97.

Van Es, S., Virdy, K.J., Pitt, G.S., Meima, M., Sands, T.W., Devreotes, P.N., Cotter, D.A. and Schaap, P. (1996). Adenylyl cyclase G, an osmosensor controling germination of Dictyostelium spores. J. Biol. Chem. 271, 23623-23625.

Schaap, P., Brandt, R. and Van Es, S. (1995). Regulation of Dictyostelium adenylyl cyclases by morphogen-induced modulation of cytosolic pH or Ca²⁺ levels. Dev. Biol. 168, 179-188.

Van Es, S, Nieuwenhuizen B.W., Lenouvel, F., Van Deursum, E.M. and Schaap, P. (1994). Universal signals control slime mold stalk formation. Proc. Natl. Acad. Sci. USA 91, 8219-8223.

Van Es, S., Hodgkinson, S., Schaap, P. and Kay, R.R. (1994). Metabolic pathways for differentiation inducing factor-1 and their regulation are conserved between closely related Dictyostelium species, but not between distant members of the family. Differentiation, 58, 95-100.

Conchita Schulkes

Schulkes, C., Verkerke-van Wijk, W. and Schaap, P. (1995). Transformation with vectors harboring the NEO^R selection marker induces germination-specific adenylylcyclase activity in Dictyostelium cells. Exp. Cell Res. 220, 505-508.

Schulkes, C. and Schaap, P. (1995). cAMP-dependent protein kinase activity is essential for preaggregative gene expression in Dictyostelium. FEBS Lett. 368, 381-384.

Dorien J. M. Peters

Ph.D. student

Schaap, P., Peters, D.J.M., Haribabu, B and Dottin, R.P. (1993) Gene regulation by hormone-like signals in Dictyostelium. in: Signal Transduction: prokaryotic and simple eukaryotic systems. eds. J. Kurjan and B.L. Taylor. Academic Press, San Diego, pp 353-376.

Peters, D.J.M., Snaar-Jagalska, B.E.,Van Haastert, P.J.M. and Schaap, P. (1992). Lithium, an inhibitor of cAMP-induced inositol 1,4,5-trisphosphate accumulation in Dictyostelium discoideum, inhibits activation of G proteins, reduces activation of adenylyl cyclase, but potentiates activation of guanylyl cyclase by cAMP. Eur. J. Biochem. 209, 299-304.

Peters, D.J.M., Cammans, M., Smit, S., Spek, W., Van Lookeren Campagne, M.M. and Schaap, P. (1991). Control of cAMP-induced gene expression by divergent signal transduction pathways. Dev.Gen. 12, 25-34.

Peters, D.J.M., Bominaar, A.A., Snaar-Jagalska, B.E., Brandt, R., Van Haastert, P.J.M., Ceccarelli, A., Williams, J.G. and Schaap, P. (1991) Selective induction of gene expression and second messenger accumulation in Dictyostelium discoideum by the partial chemotactic antagonist 8-p-chlorophenylthio-cAMP. Proc. Natl. Acad. Sci. USA. 88, 9219-9223.

Bominaar, A.A., Kesbeke, F., Snaar-Jagalska, B.E., Peters, D.J.M., Schaap, P. and Van Haastert, P.J.M. (1991) Aberrant chemotaxis and differentiation in Dictyostelium mutant fgdC with a defective regulation of receptor stimulated phosphoinositidase C. J. Cell Sci. 100, 825-831.

Peters, D.J.M., Van Lookeren Campagne, M.M., Van Haastert, P.J.M., Spek, W. and Schaap, P. (1989). Lithium ions induce prestalk-associated gene expression and inhibit prespore gene expression in Dictyostelium discoideum. J.Cell Sci. 93, 205-210

Van Lookeren Campagne, M.M., Wang, M., Spek, W., Peters, D. and Schaap, P. (1988). Lithium respecifies cyclic-AMP induced cell-type specific gene expression in Dictyostelium. Dev. Gen. 9, 589-596.

Michiel M. van Lookeren Campagne

Ph.D. student

Van Lookeren Campagne, M.M., Aerts, R.J., Spek, W., Firtel, R.A. and Schaap, P. (1989). Cyclic-AMP-induced elevation of intracellular pH precedes, but does not mediate, the induction of prespore differentiation in Dictyostelium discoideum. Development 105, 401-406.

Peters, D.J.M., Van Lookeren Campagne, M.M., Van Haastert, P.J.M., Spek, W. and Schaap, P. (1989). Lithium ions induce prestalk-associated gene expression and inhibit prespore gene expression in Dictyostelium discoideum. J.Cell Sci. 93, 205-210.

Van Lookeren Campagne, M.M., Wang, M., Spek, W., Peters, D. and Schaap, P. (1988). Lithium respecifies cyclic-AMP induced cell-type specific gene expression in Dictyostelium. Dev. Gen. 9, 589-596.

Schaap, P., Van Lookeren Campagne, M.M., Van Driel, R., Spek, W., Van Haastert, P.J.M. and Pinas, J. (1986). Postaggregative differentiation induction by cyclic AMP in Dictyostelium: Intracellular transduction pathway and requirement for additional stimuli. Dev. Biol. 118, 52-63.

Van Lookeren Campagne, M.M., Schaap, P. and Van Haastert, P.J.M. (1986). Specificity of adenosine inhibition of cAMP-induced responses in Dictyostelium resembles that of the P site of higher organisms. Dev.Biol. 117, 245-251.

Wouter Spek

Ph.D. student

Peters, D.J.M., Cammans, M., Smit, S., Spek, W., Van Lookeren Campagne, M.M. and Schaap, P. (1991). Control of cAMP-induced gene expression by divergent signal transduction pathways. Dev.Gen. 12, 25-34.

Peters, D.J.M., Van Lookeren Campagne, M.M., Van Haastert, P.J.M., Spek, W. and Schaap, P. (1989). Lithium ions induce prestalk-associated gene expression and inhibit prespore gene expression in Dictyostelium discoideum. J.Cell Sci. 93, 205-210.

Wang, M., Aerts, R.J., Spek, W. and Schaap, P. (1988). Cell cycle phase in Dictyostelium discoideum is correlated with the expression of cyclic AMP production, detection, and degradation. Dev.Biol. 125, 410-416.

Spek, W., Van Drunen, K., Van Eijk, R. and Schaap, P. (1988). Opposite effects of adenosine on two types of cAMP-induced gene expression in Dictyostelium indicate the involvement of at least two different intracellular pathways for the transduction of cAMP signals. FEBS Lett. 228, 231-234.

Van Lookeren Campagne, M.M., Wang, M., Spek, W., Peters, D. and Schaap, P. (1988). Lithium respecifies cyclic-AMP induced cell-type specific gene expression in Dictyostelium. Dev. Gen. 9, 589-596.

Schaap, P., Van Lookeren Campagne, M.M., Van Driel, R., Spek, W., Van Haastert, P.J.M. and Pinas, J. (1986). Postaggregative differentiation induction by cyclic AMP in Dictyostelium: Intracellular transduction pathway and requirement for additional stimuli. Dev. Biol. 118, 52-63

Wang Mei

Ph.D. student

Schaap, P. and Wang M. (1993). Four signals to shape a slime mold. In: Experimental and Theoretical advances in Biological Pattern Formation. eds. H.G. Othmer, P.K. Maini and J.D. Murray. NATO ASI series, Plenum Press, New York. pp 301-318.

Wang, M., Roelfsema, J.H., Williams, J.G. and Schaap, P. (1990). Cytoplasmic acidification facilitates but does not mediate DIF-induced prestalk gene expression in Dictyostelium discoideum. Dev.Biol. 140, 182-188.

Wang, M. and Schaap, P. (1989). Ammonia depletion and DIF trigger stalk cell differentiation in intact Dictyostelium discoideum slugs. Development 105, 569-574.

Wang, M., Aerts, R.J., Spek, W. and Schaap, P. (1988). Cell cycle phase in Dictyostelium discoideum is correlated with the expression of cyclic AMP production, detection, and degradation. Dev.Biol. 125, 410-416.

Wang, M., Van Driel, R. and Schaap, P. (1988). Cyclic AMP-phosphodiesterase induces dedifferentiation of prespore cells in Dictyostelium discoideum slugs: evidence that cyclic AMP is the morphogenetic signal for prespore differentiation. Development 103, 611-618.

Van Lookeren Campagne, M.M., Wang, M., Spek, W., Peters, D. and Schaap, P. (1988). Lithium respecifies cyclic-AMP induced cell-type specific gene expression in Dictyostelium. Dev. Gen. 9, 589-596.

Wang, M., Van Haastert, P.J.M., Devreotes, P.N. and Schaap, P. (1988). Localization of chemoattractant receptors on Dictyostelium discoideum cells during aggregation and down-regulation. Dev.Biol. 128, 72-77.

Wang, M., Van Haastert, P.J.M. and Schaap, P. (1986). Multiple effects of differentiation-inducing factor on prespore differentiation and cyclic-AMP signal transduction in Dictyostelium. Differentiation 33, 24-28.

Schaap, P. and Wang, M. (1986). Interactions between adenosine and oscillatory cAMP signaling regulate size and pattern in Dictyostelium. Cell 45, 137.

Schaap, P., Pinas, J.E. and Wang, M. (1985). Patterns of cell differentiation in several cellular slime mold species. Dev. Biol. 111, 51-61.

Schaap, P. and Wang, M. (1985). cAMP induces a transient elevation of cGMP levels during early culmination of Dictyostelium minutum. Cell Differ. 16, 29-33.

Wang, M. and Schaap, P. (1985). Correlations between tip dominance, prestalk/prespore pattern, and cAMP-relay efficiency in slugs of Dictyostelium discoideum. Differentiation 30, 7-14.