Researchers in Kate Storey's laboratory investigate how cells become different from each other during embryonic development.
We wish to understand how neural cells arise and how their proliferation and differentiation are controlled. Our work focuses on the developing spinal cord and insights from these studies inform our investigation of these processes in embryonic stem cell derived neural tissue and in maturing spinal cord progenitors, which become adult neural stem cells. We address these questions using cell specific gain and loss of gene function approaches as well as genome-wide analyses and real-time imaging techniques. The overall aim of our work is to identify the gene regulatory mechanisms that control neural differentiation, with a long-term goal to inform strategies for therapeutic treatment of neural injury and disease.