The Blow Lab:

CR-UK Chromosome Replication Research Group

Blow, J.J., Gillespie, P., Francis, D. and Jackson, D.A. (2001). Replication origins in Xenopus egg extract are 5-15 kb apart and are activated in clusters that fire at different times. J. Cell Biol. 152, 15-26. [abstract] [pdf]

Tada, S., Li, A., Maiorano, D., Méchali, M. and Blow, J.J. (2001). Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin. Nature Cell Biol. 3, 107-113. [abstract] [pdf]

Mattock, H., Jares, P., Zheleva, D., Lane, D.P., Warbrick, E. and Blow, J.J. (2001). Use of peptides from p21WAF1/Cip1 to investigate PCNA function in Xenopus egg extracts. Exp. Cell Res. 265, 242-251. [abstract] [pdf]

Blow, J.J. (2001). Control of chromosomal DNA replication in the early Xenopus embryo. EMBO J. 20, 3293-3297. [abstract] [pdf]

Li, A. and Blow, J.J. (2001). The origin of CDK regulation. Nat. Cell Biol. 3, E182-E184. [abstract]

Blow, J.J. (2001). Replication Licensing System. In: “DKFZ Cancer Research Encyclopaedia” (ed. M. Schwab; Springer-Verlag, Heidelberg) 769-773.

Nieduszynski, C.A., Donaldson, A.D. and Blow, J.J. (2001). Chromosome replication: from ORC to fork. Genome Biology 2(12): reports4030.1–4030.3.

Gillespie, P.J., Li, A. and Blow, J.J. (2001). Reconstitution of licensed replication origins on Xenopus sperm nuclei using purified proteins. BioMed Central Biochem. 2, 15. [abstract] [pdf]

Donaldson, A.D. and Blow, J.J. (2001). Stable driving prevents fatal smashes – DNA replication under control. Curr. Biol. 11, R979–R982. [abstract]

Blow, J.J. and Hodgson, B. (2002). Origin Licensing – Defining the Proliferative State? Trends Cell Biol. 12, 72-78. [abstract] [pdf]

Dimitrova, D.S., Prokhorova, T.A., Blow, J.J., Todorov, I., and Gilbert, D.M. (2002). Mammalian nuclei become licensed for DNA replication during late telophase. J. Cell Sci. 115, 51-59. [abstract] [pdf]

Hodgson, B., Li, A., Tada, S. and Blow, J.J. (2002). Geminin becomes activated as an inhibitor of Cdt1/RLF-B following nuclear import. Curr. Biol. 12, 678-683. [abstract] [pdf]

Shreeram, S., Sparks, A., Lane, D.P. and Blow, J.J. (2002). Cell type-specific responses of human cells to inhibition of replication licensing. Oncogene 21, 6624-6632. [Faculty of 1000 Recommendation] [abstract] [pdf]

Chapman, N.R., Webster, G.A., Gillespie, P.J., Wilson, B.J., Crouch, D.H. and Perkins, N.D. (2002) A novel form of the RelA nuclear factor kB subunit is induced by and forms a complex with the proto-oncogene c-Myc. Biochem. J. 366, 459-469. [abstract]

Woodward, A., Li, A. and Blow, J.J. (2002). Steps leading to the initiation of replication: where we are and where we may be going. Chemtracts 15, 289-312. [pdf]

Shreeram, S. and Blow, J.J. (2003). The role of the replication licensing system in cell proliferation and cancer. Progress Cell Cycle Res. 5, 287-293. [abstract] [pdf]

Blow, J.J. (2003) A new role for Ran in ensuring precise duplication of chromosomal DNA. Cell 113, 2-4. [abstract]

Li, A. and Blow, J.J. (2003) Degradation ensures integrity. Nature 423, 818-819. [abstract]

Blow, J.J. (2003) Studying DNA replication to find smarter cancer drugs. Cancer Research UK Scientific Yearbook 2002/03 36-38. [pdf]

Li, A. and Blow, J.J. (2004). Non-proteolytic inactivation of geminin requires CDK-dependent ubiquitination. Nat. Cell Biol. 6, 260-267. [abstract] [pdf]

Oehlmann, M., Score, A.J. and Blow, J.J. (2004). The role of Cdc6 in ensuring complete genome licensing and S phase checkpoint activation. J. Cell Biol. 165, 181–190. [abstract] [pdf]

Li, A. and Blow, J.J. (2004). Negative regulation of geminin by CDK-dependent ubiquitination controls replication licensing. Cell Cycle 3, 443-445. [abstract] [pdf]

Jares, P., Luciani, M.G. and Blow, J.J. (2004). A Xenopus Dbf4 homolog is required for XCdc7 chromatin binding and DNA replication. BMC Molecular Biology 5, 5. [abstract] [pdf]

Khoudoli, G.A., Porter, I.M., Blow, J.J. and Swedlow, J.R. (2004). Optimisation of the two-dimensional gel electrophoresis protocol using the Taguchi approach. Proteome Sci. 2:6. [abstract] [pdf]

Eward, K.L., Obermann, E.C., Shreeram, S., Loddo, M., Fanshawe, T., Williams, C., Jung, H.-I., Prevost, A.T., Blow, J.J., Stoeber K. and Williams, G.H. (2004). DNA replication licensing in somatic and germ cells J. Cell Sci. 117, 5875-5886. [abstract] [pdf]

Luciani, M.G., Oehlmann, M. and Blow, J.J. (2004). Characterisation of a novel ATR-dependent, Chk1-independent, intra-S phase checkpoint that suppresses initiation of replication in Xenopus. J. Cell Sci. 117, 6019-6030. [abstract] [pdf]

Ferenbach, A., Li, A., Brito-Martins, M. and Blow, J.J. (2005). Functional domains of the Xenopus replication licensing factor Cdt1. Nucleic Acids Res. 33, 316-324. [abstract] [pdf]

Li, A. and Blow, J.J. (2005). Cdt1 down-regulation by proteolysis and geminin inhibition prevents DNA re-replication in Xenopus. EMBO J. 24, 395-404. [abstract] [pdf]

Nieduszynski, C.A., Blow, J.J. and Donaldson, A.D. (2005). The requirement of replication origins for pre-replication complex proteins is modulated by transcription. Nucleic Acids Res. 33, 2410-2420. [abstract] [pdf]

Blow, J.J. and Dutta, A. (2005). Preventing re-replication of chromosomal DNA. Nat. Rev. Cell Mol. Biol. 6, 476-486. [abstract] [pdf]

Blow, J.J. and Tanaka, T.U. (2005). The chromosome cycle: coordinating replication and segregation. EMBO Rep, 6, 1028–1034. [abstract] [pdf]

Publications 2001 - 2005