The Blow Lab:

CR-UK Chromosome Replication Research Group

Publications 1996 - 2000

Chong, J.P.J., Thömmes, P. and Blow, J.J. (1996). The role of MCM/P1 proteins in the licensing of DNA replication. Trends Biochem. Sci. 21, 102-106. [abstract] [pdf]

Strausfeld, U.P., Howell, M., Descombes, P.,  Chevalier, S., Rempel, R.E., Adamczewski, J., Maller, J.L., Hunt, T. and Blow, J.J. (1996). Both cyclin A and cyclin E have S-phase promoting (SPF) activity in Xenopus egg extracts. J. Cell Sci. 109, 1555-1563. [abstract] [pdf]

Blow, J.J. (ed.) (1996). Eukaryotic DNA Replication. (Oxford University Press, Oxford).

Blow, J.J. (1996) Chromosome Replication in Xenopus Egg Extracts. In "Eukaryotic DNA Replication" (J.J. Blow, ed.; Oxford University Press, Oxford), pp 143-164.

Rowles, A., Chong, J.P.J., Brown, L., Howell, M., Evan, G.I. and Blow, J.J. (1996). Interaction Between the Origin Recognition Complex and the Replication Licensing System in Xenopus. Cell 87, 287-296. [abstract] [pdf]

Blow, J.J. and Chong, J.P.J. (1996). DNA replication and its control. In "Principles of Medical Cell Biology" (E.E. Bittar, ed.; JAI Press, Connecticut), Vol 5: "Molecular and Cellular Genetics" pp 11-31.

Romanowski, P., Madine, M.A., Rowles, A., Blow, J.J. and Laskey, R.A. (1996). Xenopus Origin Recognition Complex is essential for DNA replication and MCM binding to chromatin. Current Biol. 6, 1416-1425. [abstract] [pdf]

Blow, J.J. and Chong J.P.J. (1996). DNA replication in Xenopus. In "DNA Replication in Eukaryotic Cells" (M. DePamphilis ed.; Cold Spring Harbor Press, New York), pp 971-982.

Chevalier, S. and Blow, J.J. (1996). Cell cycle control of replication initiation in eukaryotes. Current Opinion Cell Biol. 8, 815-821. [abstract]

Chong, J.P.J. and Blow, J.J. (1996). DNA Replication Licensing Factor. Progress in Cell Cycle Research 2 (Meijer, L. and Guidet, S. eds.; Plenum Press, New York), 83-90. [abstract]

Meijer, L., Borgne, A., Mulner, O., Chong, J.P.J., Blow, J.J., Inagaki, N., Inagaki, M., Delcros, J-G., Moulinoux, J-P. (1997). Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5. Eur. J. Biochem. 243, 527-536. [abstract] [pdf]     

Mahbubani, H.M., Chong, J.P.J., Chevalier, S., Thömmes, P. and Blow, J.J. (1997). Cell cycle regulation of the replication licensing system: involvement of a Cdk-dependent inhibitor. J. Cell Biol. 136, 125-135. [abstract] [pdf]     

Rowles, A. and Blow, J.J. (1997). Chromatin proteins involved in the initiation of DNA replication. Current Opinion. Genet. Dev. 7, 152-157. [abstract]

Chong, J.P.J., Thömmes, P., Rowles, A., Mahbubani, H.M. and Blow, J.J. (1997). Characterisation of the Xenopus replication licensing system. Methods Enzymol. 283, 549-564. [abstract] [pdf]

Thömmes, P., Kubota, Y., Takisawa, H., and Blow, J.J. (1997). The RLF-M component of the replication licensing system forms complexes containing all six MCM/P1 polypeptides. EMBO J. 16, 3312-3319. [abstract] [pdf]

Blow, J.J. (1998). DNA polymerase: keeping you cloned. Biological Sci. Rev. 10, 15-17.

Tada, S. and Blow, J.J. (1998). The replication licensing system. Biological Chem. 379, 941-949. [abstract]

Tada, S., Chong, J.P.J., Mahbubani, H. and Blow, J.J. (1999). The RLF-B component of the replication licensing system is distinct from Cdc6 and functions after Cdc6 binds to chromatin. Curr. Biol. 9, 211-214. [abstract] [pdf]

Donaldson, A.D. and Blow, J.J. (1999). The regulation of replication origin activation. Curr. Opinion Genet. Dev. 9, 62-68.  [abstract]

Rowles, A., Tada, S. and Blow, J.J. (1999). Changes in association of the Xenopus Origin Recognition Complex with chromatin on licensing of replication origins. J. Cell Sci. 112, 2011-2018. [abstract] [pdf]

Blow, J.J. and Prokhorova, T.A. (1999). Saying a firm ‘no’ to DNA re-replication.      Nature Cell Biol. 1, E175-177. [abstract]

Gillespie, P.J. and Blow, J.J. (2000). Nucleoplasmin-mediated chromatin remodelling is required for Xenopus sperm nuclei to become licensed for DNA replication. Nucleic Acids Res. 28, 472-480. [abstract] [pdf]     

Prokhorova, T.A. and Blow, J.J. (2000). Sequential MCM/P1 subcomplex assembly is required to form a hetero-hexamer with replication licensing activity. J. Biol. Chem. 275, 2491-2504. [abstract] [pdf]

Sun, W.-H., Hola, M., Pedley, K., Tada, S., Blow, J.J., Todorov, I.T., Kearsey, S.E. and Brooks, R.F. (2000). The replication capacity of intact mammalian nuclei in Xenopus egg extracts declines with quiescence, but the residual DNA synthesis is independent of Xenopus MCM proteins J. Cell Sci. 113, 683-695. [abstract] [pdf]

Romanowski, P., Marr, J., Madine, M.A., Rowles, A., Blow, J.J., Gautier, J. and Laskey, R.A. (2000). Interaction of Xenopus Cdc2.Cyclin A1 with the Origin Recognition Complex. J. Biol. Chem. 275, 4239-4243. [abstract] [pdf]

Blow, J.J. and Tada, S. (2000). A new check on issuing the licence. Nature 404, 650-651. [abstract]•

Jares, P. and Blow, J.J. (2000). Xenopus Cdc7 function is dependent on licensing but not on XORC, XCdc6 or CDK activity and is required for XCdc45 loading. Genes Dev. 14, 1528-1540. [abstract] [pdf]     

Jares, P., Donaldson A.D. and Blow, J.J. (2000). The Cdc7 protein kinase - target of the S phase checkpoint? EMBO Reports 1, 319-322. [abstract] [pdf]

Blow, J.J. (ed.) (2000). Cell multiplication. Current Opinion. Cell Biol. 12, vol 6. [abstract]