DR JOOST ZOMERDIJK

+44 (0) 1382 384242, INTERNAL EXT. 84242

GENE REGULATION AND EXPRESSION

COLLEGE OF LIFE SCIENCES, UNIVERSITY OF DUNDEE

Molecular Mechanisms and Control in Transcription by RNA polymerase I

Ribosomal RNAs are the key components of ribosomes, the protein synthesis factories of a cell, and each cell needs to make millions of copies to sustain cell growth and proliferation. In eukaryotes, the major ribosomal RNAs are produced by RNA Polymerase I transcription of the ribosomal RNA genes, which takes place in the nucleolus. Complex cellular mechanisms operate to control RNA Polymerase I transcription of the ribosomal RNA genes. Deregulation of such transcription can disrupt normal cell growth, causing cell death or runaway growth, and has been implicated in certain developmental defects and cancers.

The Zomerdijk Laboratory investigates how ribosomal RNA genes are transcribed by RNA polymerase I in mammalian cells, how this process is regulated and how it affects cell growth and proliferation.

To see details of our research Click Here

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