Mechanism of Mitotic Chromosome Condensation

Mitotic chromosome segregation requires proper chromosome assembly and the phosphorylation of a number of chromosomal proteins. The Aurora B protein kinase and its binding partners INCENP and survivin have a critical role in this process..... read more

Dynamics of the Interphase Nucleus

The interphase nucleus is a dynamic, yet surprisingly tightly-packed organelle. As a model for intranuclear mobility, we are studying the dynamics of the Cajal body..... read more

Cell Cycle Chromatin Proteomics

The events of the cell cycle have profound effects on nuclei and chromosomes. Chromosome replication, nuclear disassembly and reassembly, chromosome condensation and apoptosis all involve proteins that directly interact with chromatin..... read more

Image Informatics in Biological Microscopy

Digital fluorescence imaging is used in functional genomics, genetic and chemical screens, and cell biology for assays of molecular localization, interaction and mobility. However, there is no solution for systematically managing and analyzing this data..... read more