Publications 2010

Leachman SA, Hickerson RP, Schwartz ME, Bullough EE, Hutcherson SL, Boucher KM, Hansen CD, Eliason MJ, Srivastsa GS, Kornbrust DJ, Smith FJDMcLean WHI, Milstone LM and Kaspar RL (2010) First-in-human Mutation-targeted siRNA Phase Ib Trial of an Inherited Skin Disorder. Mol Ther 8:442-6 [Epub ahead of print 24th November 2009].  (Pub Med ID: 19935778)

O’Regan GM, Campbell LE, Cordell HJ, Irvine AD, McLean WHI and Brown SJ (2010) Chromosome 11q13.5 variant associated with childhood atopic eczema; an effect supplementary to filaggrin mutations. J Allergy Clin Immunol, 125:170-174  (Pub Med ID: 20109745)

Bergboer JG, Zeeuwen PL, Irvine AD, Weidinger S, Giardina E, Novelli G, Den Heijer M, Rodriguez E, Illig T, Riveira-Munoz E, Campbell LE, Tyson J, Dannhauser EN, O'Regan GM, Galli E, Klopp N, Koppelman GH, Novak N, Estivill X, McLean WHI, Postma DS, Armour JA and Schalkwijk J. (2010) Deletion of Late Cornified Envelope 3B and 3C genes is not associated with atopic dermatitis. J Invest Dermatol 130:2057-2061. (Pub Med ID: 20376060)

O'Regan GM, Kemperman PM, Sandilands A, Chen H, Campbell LE, Kroboth K, Watson R, Rowland M, Puppels GJ, McLean WHI, Caspers PJ and Irvine AD. (2010) Raman profiles of the stratum corneum define 3 filaggrin genotype-determined atopic dermatitis endophenotypes. J Allergy Clin Immunol. 126:574-80 [Epub ahead of print 9th July 2010]. (Pub Med ID: 20621340)

Chervet L, Galichet A, McLean WHI, Chen H, Suter MM, Roosje PJ and Müller EJ. (2010) Missing C-terminal filaggrin expression, NFkappaB activation and hyperproliferation identify the dog as a putative model to study epidermal dysfunction in atopic dermatitis. Exp Dermatol 19:e343-346. (Pub Med ID: 20626465)

Osawa R, Konno S, Akiyama M, Nemoto-Hasebe I, Nomura T, Nomura Y, Abe R, Sandilands AMcLean WHI, Hizawa N, Nishimura M and Shimizu H. (2010) Japanese-specific filaggrin gene mutations in Japanese patients suffering from atopic eczema and asthma. J Invest Dermatol. 130:2834-2836. [Epub ahead of print Aug 5] (PMID: 20686498)

Nomura Y, Akiyama M, Nomura T, Nemoto-Hasebe I, Abe R, McLean WHI and Shimizu H. (2010) Chromosome 11q13.5 variant: No association with atopic eczema in the Japanese population. J Dermatol Sci. 59:210-212 [Epub ahead of print 7th July 2010]. (Pub Med ID: 20656460)

Strange A, Capon F, Spencer CC, Knight J, Weale ME, Allen MH, Barton A, Band G, Bellenguez C, Bergboer JG, Blackwell JM, Bramon E, Bumpstead SJ, Casas JP, Cork MJ, Corvin A, Deloukas P, Dilthey A, Duncanson A, Edkins S, Estivill X, Fitzgerald O, Freeman C, Giardina E, Gray E, Hofer A, Hüffmeier U, Hunt SE, Irvine AD, Jankowski J, Kirby B, Langford C, Lascorz J, Leman J, Leslie S, Mallbris L, Markus HS, Mathew CG, McLean WHI, McManus R, Mössner R, Moutsianas L, Naluai AT, Nestle FO, Novelli G, Onoufriadis A, Palmer CN, Perricone C, Pirinen M, Plomin R, Potter SC, Pujol RM, Rautanen A, Riveira-Munoz E, Ryan AW, Salmhofer W, Samuelsson L, Sawcer SJ, Schalkwijk J, Smith CH, Ståhle M, Su Z, Tazi-Ahnini R, Traupe H, Viswanathan AC, Warren RB, Weger W, Wolk K, Wood N, Worthington J, Young HS, Zeeuwen PL, Hayday A, Burden AD, Griffiths CE, Kere J, Reis A, McVean G, Evans DM, Brown MA, Barker JN, Peltonen L, Donnelly P and Trembath RC. (2010) A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. Nat Genet 42:985-990 [Epub ahead of print 17th Oct]. (PubMed ID: 20953190)

Jakasa I, Koster ES, Calkoen F, McLean WHI, Campbell LE, Bos JD, Verberk MM and Kezic S. (2010) Skin Barrier Function in Healthy Subjects and Patients with Atopic Dermatitis in Relation to Filaggrin Loss-of-Function Mutations. J Invest Dermatol 131:540-542 [Epub ahead of print 21st Oct] (Pub Med ID: 20962854)

Flohr C, England K, Radulovic S, McLean WHI, Campbell LE, Barker J, Perkin M and Lack G. (2010) Filaggrin loss-of-function mutations are associated with early-onset eczema, eczema severity and transepidermal water loss at 3 months of age. Br J Dermatol 163:1333-1336. (PubMed ID: 21137118)