Frank Sargent is a principal investigator in the Division of Molecular Microbiology within the College of Life Sciences at the University of Dundee.
Work in this research group concentrates on the molecular biology of bacterial respiration and fermentation. Escherichia coli and Salmonella enterica are related bacteria that display versatile metabolic capabilities. These bacteria can grow easily in the absence of oxygen either by substituting a number of different organic or inorganic compounds as electron acceptors, or by switching to a fermentative metabolism. This respiratory flexibility is thanks to a bank of different respiratory enzymes available to these bacteria.
Targeting of GFP to the bacterial periplasm
A transport mutant forms long chains of cells
The crystal structure of the SufI protein