School of Life Sciences
University of Dundee

* Full open access.
# Free from PMC.
^ Complimentary access.
 

Selected research – last 7 years

Aquaglyceroporin-null trypanosomes display glycerol transport defects and respiratory-inhibitor sensitivity. *
Jeacock L, Baker N, Wiedemar N, Mäser P and Horn D. (2017) PLoS Pathogens. 13:e1006307
VEX1 controls the allelic exclusion required for antigenic variation in trypanosomes. *
Glover L, Hutchinson S, Alsford  S and Horn D. (2016) Proc. Natl. Acad. Sci. USA113:7225-30
Vacuolar ATPase depletion affects mitochondrial ATPase function, kinetoplast dependency and drug-sensitivity in trypanosomes. *
Baker N, Hamilton G, Wilkes J, Hutchinson S, Barrett MP, Horn D. (2015)  Proc. Natl. Acad. Sci. USA. 112:9112-9117
Cathepsin-L can resist lysis by human serum in Trypanosoma brucei brucei. *
Alsford S, Currier RB, Guerra-Assunção JA, Clark TG, Horn D (2014) PLoS Pathogens10:e1004130
Locus-specific control of DNA resection and suppression of subtelomeric VSG recombination by HAT3 in the African trypanosome. *
Glover L, Horn D (2014) Nucleic Acids Res. 42:12600-12613
DNA break site at fragile subtelomeres determines probability and mechanism of antigenic variation in African trypanosomes. * 
Glover L, Alsford S and Horn D (2013) PLoS Pathogens 9:e1003260
Cell cycle regulated control of VSG expression site silencing by histones and histone chaperones ASF1A and CAF-1b in Trypanosoma brucei. * 
Alsford S and Horn D (2012) Nucleic Acids Res. 40:10150-60
Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes. *
Baker N, Glover L, Munday JC, Aguinaga Andrés D, Barrett MP, de Koning HP and Horn D (2012) Proc. Natl. Acad. Sci. USA 109:10996–11001
High-throughput decoding of antitrypanosomal drug efficacy and resistance. #
Alsford S, Eckert S, Baker N, Glover L, Sanchez-Flores A, Leung K, Turner DJ, Field MC, Berriman M and Horn D. (2012) Nature 482:232-236 PMC
Elongator protein 3b negatively regulates ribosomal DNA transcription in African trypanosomes. * 
Alsford S and Horn D. (2011) Mol Cell Biol 31:1822-1832
Microhomology mediated deletion and gene conversion in African trypanosomes. * 
Glover L, Jun J and Horn D. (2011) Nucleic Acids Res. 39:1372-1380
High throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome. *
Alsford S, Turner DJ., Obado SO, Sanchez-Flores A, Glover L, Berriman M, Hertz-Fowler C and Horn D. (2011) Genome Research 21:915-924

Selected research collaborations – last 5 years

Distinct activation mechanisms trigger the trypanocidal activity of DNA damaging prodrugs. *
Meredith EL, Kumar A, Konno A, Szular J, Alsford S, Seifert K, Horn D and Wilkinson SR. (2017) Mol. Microbiol. 106:207-222
Genome-wide and protein kinase-focused RNAi screens reveal conserved and novel damage response pathways in Trypanosoma brucei *
Stortz JA, Serafim TD, Alsford S, Wilkes J, Fernandes-Cortes F, Hamilton G, Briggs E, Lemgruber L, Horn D, Mottram JC and McCulloch R. (2017) PLoS Pathogens.13:e1006477
Genome-wide RNAi selection identifies a regulator of transmission stage-enriched gene families and cell-type differentiation in Trypanosoma brucei. *
Rico E, Ivens A, Glover L, Horn D and Matthews K. (2017) PLoS Pathogens. 13:e1006279
The role of folate transport in antifolate drug action in Trypanosoma brucei. *
Dewar S, Sienkiewicz N, Ong HB, Wall RJ, Horn D and Fairlamb AH. (2016) J. Biol. Chem. 291:24768–24778
Co-dependence between trypanosome nuclear lamina components in nuclear stability and control of gene expression. *
Maishman L, Obado SO, Alsford S, Bart J, Chen W, Ratushny AV, Navarro M, Horn D, Aitchison JD, Chait BT, Rout MP and Field MC. (2016) Nucleic Acids Res. 44:10554-10570
Pentamidine is not a permeant but a nanomolar inhibitor of the Trypanosoma brucei aquaglyceroporin-2. *
Song J, Baker N, Rothert M, Henke B, Jeacock L, Horn D, Beitz E. (2016) PLoS Pathogens12:e1005436
Modulation of the surface proteome through multiple ubiquitylation pathways in African trypanosomes. *
Zoltner M, Leung K-F, Alsford S, Horn D and Field MC. (2015) PLoS Pathogens11:e1005236
Chimerization at the AQP2-AQP3 locus is the genetic basis of melarsoprol-pentamidine cross-resistance in clinical Trypanosoma brucei gambiense isolates. *
Graf FE, Baker N, Munday JC, de Koning HP, Horn D, Mäser P. (2015) Int. J. Parasitol; Drugs & Drug Resistance 5:65-68
Genome wide dissection of the quorum sensing signaling pathway in Trypanosoma brucei. #
Mony BM, MacGregor P, Ivens A, Rojas F, Cowton A, Wilson J, Horn D and Matthews KR (2014) Nature. 505:681-685
Cyclic AMP effectors in African trypanosomes revealed by genome-scale RNAi library screening for resistance to the phosphodiesterase inhibitor Cpd A. * 
Gould MK, Bachmaier S, Ali JA, Alsford S, Tagoe DN, Munday JC, Schnaufer AC, Horn D, Boshart M and de Koning HP (2013) Antimicrob. Agents Chemother. 57:4882-93
PPL2 translesion polymerase is essential for the completion of chromosomal DNA replication in the African trypanosome. * 
Rudd SG, Glover L, Jozwiakowski SK, Horn D and Doherty AJ (2013) Mol. Cell 52:554-565
NUP-1 Is a large coiled-coil nucleoskeletal protein in trypanosomes with lamin-like functions. * 
duBois K, Alsford S, Buisson J, Swiderski M, Bart J, Bastin P, Barry D, Navarro M, Horn D, Aitchison J, Rout M and Field M. (2012) PLOS Biology 10:e1001287

Selected Reviews – last 5 years

Anti-trypanosomatid drug discovery: An ongoing challenge and a continuing need.
Field MC, Horn D, Fairlamb AH, Ferguson MAJ, Gray DW, Read KD, De Rycker M, Torrie LS, Wyatt PG, Wyllie S and Gilbert IH. (2017) Nature Reviews Microbiol. 15:217-231.
Epigenetic regulation of virulence gene expression in parasitic protozoa.
Duraisingh MT and Horn D. (2016) Cell Host & Microbe.  19:629-640 / Comlimentary access.
Research Matters: How antiparasitic drugs work – and sometimes stop working! *
Horn D. (2016) PLoS Pathogens12:e1005430
Protocol: Genome-scale RNAi screens for high-throughput phenotyping in bloodstream form African trypanosomes.
Glover L, Alsford S, Baker N, Turner DJ, Sanchez-Flores A, Hutchinson S, Hertz-Fowler C, Berriman M and Horn D (2015) Nature Protocols10:106–133
Antigenic variation in African trypanosomes. *
Horn D. (2014) Mol. Biochem. Parasitol. 195:123-129
Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story. # 
Baker N, de Koning HP, Mäser P and Horn D. (2013) Trends in Parasitol. 29:110-118 PMC

All publications

2017

Distinct activation mechanisms trigger the trypanocidal activity of DNA damaging prodrugs. *
Meredith EL, Kumar A, Konno A, Szular J, Alsford S, Seifert K, Horn D and Wilkinson SR. (2017) Mol. Microbiol. 106:207-222
Ornithine uptake and the modulation of drug sensitivity in Trypanosoma brucei. *
Macedo JP, Currier RB, Wirdnam C, Horn D, Alsford S and Rentsch D.  (2017) FASEB Journal. 10:4649-4660
Genome-wide and protein kinase-focused RNAi screens reveal conserved and novel damage response pathways in Trypanosoma brucei *
Stortz JA, Serafim TD, Alsford S, Wilkes J, Fernandes-Cortes F, Hamilton G, Briggs E, Lemgruber L, Horn D, Mottram JC and McCulloch R. (2017) PLoS Pathogens. 13:e1006477
Aquaglyceroporin-null trypanosomes display glycerol transport defects and respiratory-inhibitor sensitivity. *
Jeacock L, Baker N, Wiedemar N, Mäser P and Horn D. (2017) PLoS Pathogens. 13:e1006307
Genome-wide RNAi selection identifies a regulator of transmission stage-enriched gene families and cell-type differentiation in Trypanosoma brucei. *
Rico E, Ivens A, Glover L, Horn D and Matthews K. (2017) PLoS Pathogens. 13:e1006279
Review: Anti-trypanosomatid drug discovery: An ongoing challenge and a continuing need.
Field MC, Horn D, Fairlamb AH, Ferguson MAJ, Gray DW, Read KD, De Rycker M, Torrie LS, Wyatt PG, Wyllie S and Gilbert IH. (2017) Nature Reviews Microbiol. 15:217-231.

2016

High-resolution analysis of multi-copy variant surface glycoprotein gene expression sites in African trypanosomes. *
Hutchinson S, Glover L and Horn D. (2016) BMC Genomics. 17:806
The role of folate transport in antifolate drug action in Trypanosoma brucei. *
Dewar S, Sienkiewicz N, Ong HB, Wall RJ, Horn D and Fairlamb AH. (2016) J. Biol. Chem. 291:24768–24778
Co-dependence between trypanosome nuclear lamina components in nuclear stability and control of gene expression. *
Maishman L, Obado SO, Alsford S, Bart J, Chen W, Ratushny AV, Navarro M, Horn D, Aitchison JD, Chait BT, Rout MP and Field MC. (2016) Nucleic Acids Res. 44:10554-10570
VEX1 controls the allelic exclusion required for antigenic variation in trypanosomes. *
Glover L, Hutchinson S, Alsford  S and Horn D. (2016) Proc. Natl. Acad. Sci. USA113:7225-30
Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense. ^
Graf FE, Ludin P, Arquint C, Schmidt RS,  Schaub N, Kunz-Renggli C, Munday JC, Krezdorn J,  Baker N, Horn D, Balmer O, Caccone A, de Koning HP and Mäser P. (2016) Cellular and Molecular Life Sciences. 73:3387-3400 / Free access.
Pentamidine is not a permeant but a nanomolar inhibitor of the Trypanosoma brucei aquaglyceroporin-2. *
Song J, Baker N, Rothert M, Henke B, Jeacock L, Horn D, Beitz E. (2016) PLoS Pathogens. 12:e1005436
Opinion: Exploiting the Achilles' heel of membrane trafficking in trypanosomes. *
Zoltner M, Horn D, de Koning HP and Field MC. (2016) Curr. Opin. Microbiol. 34:97-103
Review: Epigenetic regulation of virulence gene expression in parasitic protozoa.
Duraisingh MT and Horn D. (2016) Cell Host & Microbe.  19:629-640 / Comlimentary access.
Research Matters: How antiparasitic drugs work – and sometimes stop working! *
Horn D. (2016) PLoS Pathogens. 12:e1005430

2015

Modulation of the surface proteome through multiple ubiquitylation pathways in African trypanosomes. *
Zoltner M, Leung K-F, Alsford S, Horn D and Field MC. (2015) PLoS Pathogens. 11:e1005236
Vacuolar ATPase depletion affects mitochondrial ATPase function, kinetoplast dependency and drug-sensitivity in trypanosomes. *
Baker N, Hamilton G, Wilkes J, Hutchinson S, Barrett MP, Horn D. (2015)  Proc. Natl. Acad. Sci. USA. 112:9112-9117
Chimerization at the AQP2-AQP3 locus is the genetic basis of melarsoprol-pentamidine cross-resistance in clinical Trypanosoma brucei gambiense isolates. *
Graf FE, Baker N, Munday JC, de Koning HP, Horn D, Mäser P. (2015) Int. J. Parasitol; Drugs & Drug Resistance 5:65-68
Trypanosoma brucei J protein 2 is a stress inducible and essential Hsp40.
Ludewig MH, Boshoff A, Horn D, Blatch GL. (2015) Int. J. of Biochem. & Cell Biol. 60:93-98
Protocol: Genome-scale RNAi screens for high-throughput phenotyping in bloodstream form African trypanosomes.
Glover L, Alsford S, Baker N, Turner DJ, Sanchez-Flores A, Hutchinson S, Hertz-Fowler C, Berriman M and Horn D (2015) Nature Protocols. 10:106–133

2014

Locus-specific control of DNA resection and suppression of subtelomeric VSG recombination by HAT3 in the African trypanosome. *
Glover L, Horn D (2014) Nucleic Acids Res. 42:12600-12613
Cathepsin-L can resist lysis by human serum in Trypanosoma brucei brucei. *
Alsford S, Currier RB, Guerra-Assunção JA, Clark TG, Horn D (2014) PLoS Pathogens. 10:e1004130
Genome wide dissection of the quorum sensing signaling pathway in Trypanosoma brucei. #
Mony BM, MacGregor P, Ivens A, Rojas F, Cowton A, Wilson J, Horn D and Matthews KR (2014) Nature. 505:681-685
Trypanosoma brucei Aquaglyceroporin 2 is a high affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs. *
Munday J, Eze A, Baker N, Glover L, Clucas C, Aguinaga Andres D, Natto M, Teka I, McDonald J, Lee R, Graf F, Ludin P, Burchmore R, Turner MC, Tait A, McLeod A, Mäser P, Barrett M, Horn D and de Koning HP (2014) J. Antimicrob. Chemother. 69:651-63
Review: Antigenic variation in African trypanosomes. *
Horn D. (2014) Mol. Biochem. Parasitol. 195:123-129
Review: Antiparasitic Chemotherapy: From Genomes to Mechanisms. ^
Horn D and Duraisingh MT. (2014) Annual Review of Pharmacology and Toxicology. 54:71-94 Complimentary access
Review: High-throughput decoding of drug targets and drug resistance mechanisms in African trypanosomes.
Horn D. (2014) Parasitology. 141:77-82
Book Chapter: Subtelomeres.
Figueiredo LM and Horn D (2014) Springer. Trypanosoma brucei subtelomeres - Chapter 7

2013

 

PPL2 translesion polymerase is essential for the completion of chromosomal DNA replication in the African trypanosome. *
Rudd SG, Glover L, Jozwiakowski SK, Horn D and Doherty AJ (2013) Mol. Cell 52:554-565

 

 

Aquaporin 2 mutations in Trypanosoma brucei gambiense field isolates correlate with decreased susceptibility to pentamidine and melarsoprol. *
Graf FE, Ludin P, Wenzler T, Kaiser M, Brun R, Pyana PP, Büscher P, de Koning HP, Horn D and Mäser P. (2013) PLoS Neglected Tropical Diseases 7:e2475

 

 

Cyclic AMP effectors in African trypanosomes revealed by genome-scale RNAi library screening for resistance to the phosphodiesterase inhibitor Cpd A. *
Gould MK, Bachmaier S, Ali JA, Alsford S, Tagoe DN, Munday JC, Schnaufer AC, Horn D, Boshart M and de Koning HP (2013) Antimicrob. Agents Chemother. 57:4882-93

 

 

DNA break site at fragile subtelomeres determines probability and mechanism of antigenic variation in African trypanosomes. *
Glover L, Alsford S and Horn D (2013) PLoS Pathogens 9:e1003260

 

 

Review: Antigenic variation in African trypanosomes: the importance of chromosomal and nuclear context in VSG expression control. *
Glover L, Hutchinson S, Alsford S, McCulloch R, Field MC and Horn D. (2013) Cell. Microbiol. 15:1984-93

 

 

Review: Genetic dissection of drug resistance in trypanosomes. *
Alsford S, Kelly JM, Baker N and Horn D. (2013) Parasitology 140:1478-1491

 

 

Opinion: Receptor mediated endocytosis for drug delivery in African Trypanosomes: fulfilling Paul Ehrlich’s vision of chemotherapy.
Alsford S, Field MC and Horn D. (2013) Trends in Parasitology 29:207-212

 

 

Review: Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story. #
Baker N, de Koning HP, Mäser P and Horn D. (2013) Trends in Parasitol. 29:110-118 PMC

 

2012

 

Cell cycle regulated control of VSG expression site silencing by histones and histone chaperones ASF1A and CAF-1b in Trypanosoma brucei. *
Alsford S and Horn D (2012) Nucleic Acids Res. 40:10150-60

 

 

Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes. *
Baker N, Glover L, Munday JC, Aguinaga Andrés D, Barrett MP, de Koning HP and Horn D (2012) Proc. Natl. Acad. Sci. USA 109:10996–11001

 

 

NUP-1 Is a large coiled-coil nucleoskeletal protein in trypanosomes with lamin-like functions. *
duBois K, Alsford S, Buisson J, Swiderski M, Bart J, Bastin P, Barry D, Navarro M, Horn D, Aitchison J, Rout M and Field M. (2012) PLOS Biology 10:e1001287

 

 

Inhibitors of human histone deacetylase with potent activity against the African trypanosome Trypanosoma brucei. *
Kelly J, Taylor M, Horn D, Loza E, Kalvinsh I and Björkling F. (2012) Bioorganic & Medicinal Chemistry Letters 22:1886-90

 

 

Trypanosomal histone gamma-H2A and the DNA damage response. *
Glover L and Horn D. (2012) Mol. Biochem. Parasitol. 183:78-83

 

 

High-throughput decoding of antitrypanosomal drug efficacy and resistance. #
Alsford S, Eckert S, Baker N, Glover L, Sanchez-Flores A, Leung K, Turner DJ, Field MC, Berriman M and Horn D. (2012) Nature 482:232-236 PMC

 

 

Extraview: Telomeres, tethers and trypanosomes. *
Field MC, Horn D, Alsford S, Koreny L and Rout MP. (2012) Nucleus 3:1-9

 

 

Review: Epigenetic mechanisms, nuclear architecture and the control of gene expression in trypanosomes.
Alsford S, Dubois K, Horn D and Field MC. (2012) Expert Rev Mol Med 14:e13

 

2011

 

High throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome. *
Alsford S, Turner DJ., Obado SO, Sanchez-Flores A, Glover L, Berriman M, Hertz-Fowler C and Horn D. (2011) Genome Research 21:915-924

 

 

Elongator protein 3b negatively regulates ribosomal DNA transcription in African trypanosomes. *
Alsford S and Horn D. (2011) Mol Cell Biol 31:1822-1832

 

 

Microhomology mediated deletion and gene conversion in African trypanosomes. *
Glover L, Jun J and Horn D. (2011) Nucleic Acids Res 39:1372-1380

 

 

Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6. *
Baker N, Alsford S and Horn D. (2011) Mol Biochem Parasitol 176:55-57

 

2010

 

Histone deacetylases play distinct roles in telomeric VSG expression site silencing in African trypanosomes. *
Wang Q-P, Kawahara T and Horn D. (2010) Mol Microbiol 77:1237-1245

 

 

RNA interference, growth and differentiation appear normal in African trypanosomes lacking Tudor staphylococcal nuclease. *
Alsford S, Kemp LE, Kawahara T and Horn D. (2010) Mol Biochem Parasitol 174:70-73

 

 

Review: Molecular mechanisms underlying the control of antigenic variation in African trypanosomes. *
Horn D and McCulloch R. (2010) Curr Opin Microbiol 13:700-705

 

2009

 

Site-specific DNA double-strand breaks greatly increase stable transformation efficiency in Trypanosoma brucei. *
Glover L and Horn D. (2009) Mol Biochem Parasitol 166:194-197

 

 

Opinion: What has DNA sequencing revealed about the VSG Expression Sites of African Trypanosomes?
McCulloch R and Horn D. (2009) Trends Parasitol 8:359-363

 

 

Dispatch: Antigenic variation: Extending the reach of telomeric silencing. *
Horn D. (2009) Curr Biol 19:R496-498

 

 

Minireview: DNA breaks as triggers for antigenic variation in African trypanosomes. *
Alsford S, Horn D and Glover L. (2009) Genome Biol 10:223

 

2008

 

Two essential MYST-family proteins display distinct roles in histone H4K10 acetylation and telomeric silencing in trypanosomes. *
Kawahara T, Siegel TN, Ingram AK, Alsford S, Cross GAM and Horn D. (2008) Mol Microbiol 69:1054-1068

 

 

Single-locus targeting vectors for regulated transgene expression and RNAi in T. brucei. #
Alsford S and Horn D. (2008) Mol Biochem Parasitol 161:76-79 PMC

 

 

A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes. *
Wilkinson SR, Taylor MC, Horn D, Kelly JM and Cheeseman I. (2008) Proc Natl Acad Sci USA 105:5022-5027

 

 

Sequence homology and microhomology dominate chromosomal double-strand break repair in African trypanosomes. *
Glover L, McCulloch R and Horn D. (2008) Nucleic Acids Res 36:2608-2618

 

 

Acetylation of histone H4K4 is cell-cycle regulated and mediated by HAT3 in Trypanosoma brucei. *
Siegel TN, Kawahara T, DeGrasse JA, Janzen CJ, Horn D and Cross GAM. (2008) Mol Microbiol 67:762-771

 

 

Codon usage suggests that translational selection has a major impact on protein expression in trypanosomatids. *
Horn D. (2008) BMC Genomics 9:2

 

 

Book Chapter: Analysis of small GTPase function in trypanosomes.
Field MC, Horn D and Carrington M (2008) Elsevier. Methods Enzymol 438:57-76

 

 

Book Chapter: Histone Deacetylases.
Horn D (2008) Landes Bioscience. Drug targets in kinetoplastid parasites Chapter.

 

2007

 

RNA polymerase I transcription stimulates homologous recombination in Trypanosoma brucei. #
Alsford S and Horn D. (2007) Mol Biochem Parasitol 153:77-9 PMC

 

 

Deletion of a trypanosome telomere leads to loss of silencing and progressive loss of terminal DNA in the absence of cell cycle arrest. *
Glover L, Alsford S, Beattie C and Horn D. (2007) Nucleic Acids Res 35:872-80

 

 

A sirtuin in the African trypanosome is involved in both DNA repair and telomeric gene silencing but is not required for antigenic variation. *
Alsford S, Kawahara T, Isamah C and Horn D. (2007) Mol Microbiol 63:724-36

 

 

Deletion of the Trypanosoma brucei superoxide dismutase gene Tbsodb1 increases sensitivity to nifurtimox and benznidazole. *
Prathalingham SR, Wilkinson SR, Horn D and Kelly JM. (2007) Antimicrob Agents Chemother 51:755-58

 

 

Research Focus: Introducing histone modification in trypanosomes. #
Horn D. (2007) Trends Parasitol 23:239-42 PMC

 

 

Book Chapter: Chromosome structure and dynamics.
Renauld H, Kelly JM and Horn D (2007) Horizon Press. Trypanosomes – after the genome Chapter 4.

 

2006

 

Chromsome-wide analysis of gene function by RNA interference in the African trypanosome. *
Subramaniam C, Veazey P, Redmond S, Hayes-Sinclair J, Chambers E, Carrington M, Gull K, Matthews K, Horn D and Field MC. (2006) Eukaryotic Cell 5:1539-1549

 

 

Functional characterisation of the iron superoxide dismutase gene repertoire in Trypanosoma brucei.
Wilkinson SR, Prathalingam SR, Taylor MC, Ahmed A, Horn D and Kelly JM (2006) Free Radic Biol Med 40:198-209

 

 

Repression of polymerase I-mediated gene expression at Trypanosoma brucei telomeres. *
Glover L and Horn D (2006) EMBO Rep 7:93-9

 

2005

 

Tagging a T. brucei RRNA locus improves stable transfection efficiency and circumvents inducible expression position effects. #
Alsford S, Kawahara T, Glover L and Horn D (2005) Mol Biochem Parasitol 144:142-8 PMC

 

 

Vitamin C biosynthesis in trypanosomes: a role for the glycosome. *
Wilkinson SR, Prathalingam SR, Taylor MC, Horn D and Kelly JM (2005) Proc Natl Acad Sci USA 102:11645-50

 

 

The genome of the kinetoplastid parasite, Leishmania major. #
Ivens AC … Horn D … Myler PJ (2005) Science 309:436-42 PMC

 

 

The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease.
El-Sayed NM … Horn D … Andersson B (2005) Science 309:409-15

 

 

Directional enrichment of directly cloned PCR products. *
Horn D (2005) Biotechniques 39:40-46.

 

 

Multiplex analysis of RNA interference defects in Trypanosoma brucei. #
Alsford S, Glover L and Horn D (2005) Mol Biochem Parasitol 139:129-32 PMC

 

 

A doubly inducible system for RNA interference and rapid RNAi plasmid construction in Trypanosoma brucei.
Alibu VP, Storm L, Haile S, Clayton C and Horn D (2005) Mol Biochem Parasitol 139:75-82

 

 

Review: The central roles of telomeres and subtelomeres in antigenic variation in African trypanosomes. *
Horn D and Barry JD (2005) Chromosome Res 13:525-33

 

 

Book Chapter: Down-regulating gene expression by RNA interference in Trypanosoma brucei.
Clayton CE, Estevez AM, Hartmann C, Alibu VP, Field M and Horn D (2005) Methods Mol Biol 309:39-60

 

pre-2005

 

Review: The molecular control of antigenic variation in Trypanosoma brucei.
Horn D (2004) Curr Mol Med 4:563-76

 

 

Review: Trypanosomatid Histones. *
Alsford S and Horn D (2004) Mol Micro 53:365-72

 

 

RNAi identifies two hydroperoxide metabolising enzymes that are essential to the bloodstream form of the African trypanosome. *
Wilkinson SR, Horn D, Prathalingam R, and Kelly JM (2003) J Biol Chem 278:31640-6

 

 

Histone deacetylases in Trypanosoma brucei: Two are essential and another is required for normal cell cycle progression. *
Ingram AK and Horn D (2002) Mol Microbiol 45:89-97

 

 

Review: Nuclear gene transcription and chromatin in Trypanosoma brucei
Horn D (2001) Int J Parasitol 31:1157-65

 

 

Telomere maintenance and length regulation in Trypanosoma brucei. *
Horn D, Spence C and Ingram AK (2000) EMBO J 19:2332-9

 

 

Genetic manipulation indicates that ARD1 is an essential N-terminal protein acetyltransferase in Trypanosoma brucei.
Ingram AK, Cross GAM and Horn D (2000) Mol Biochem Parasitol 111:309-17

 

 

Position-dependent and promoter-specific regulation of gene expression in Trypanosoma brucei. *
Horn D and Cross GAM (1997) EMBO J 16:7422-31

 

 

Analysis of Trypanosoma brucei VSG expression site switching in vitro.
Horn D and Cross GAM (1997) Mol Biochem Parasitol 84:189-201

 

 

A developmentally regulated position effect at a telomeric locus in Trypanosoma brucei. *
Horn D and Cross GAM (1995) Cell 83:555-61

 

 

Mice lacking Snrpn expression show normal regulation of neuronal alternative splicing events.
Huntriss JD, Barr JA, Horn D, Williams DG and Latchman DS (1994) Mol. Biol. Rep. 20:19-25

 

 

The cardiac form of the tissue-specific protein SmN is identical to the brain and embryonic forms of the protein.
Gerrelli D, Grimaldi K, Horn D, Mahadeva U, Sharpe N and Latchman DS (1993) J. Mol. Cell. Cardiol. 25:321-329

 

 

Expression of the SmN splicing protein is developmentally regulated in the rodent brain but not in the rodent heart.
Grimaldi K, Horn D, Hudson LD, Terenghi G, Polak JM and Latchman DS (1993) Dev. Biol. 156:319-323

 

 

The tissue specific SmN protein does not influence the alternative splicing of endogenous N-Cam and C-SRC RNAs in transfected 3T3 cells.
Horn D and Latchman DS (1993) Brain Res: Mol. Brain Res. 19:181-187

 

 

Alternative splicing of the mRNA encoding the a subunits of the G(o) GTP-binding protein during brain development and in neuronal cell lines.
Horn D and Latchman DS (1993) Neurosci. Lett. 155:57-60

 

 

A distal region of the CALC-I gene is necessary for regulated alternative splicing.
Horn D and Latchman DS (1993) FEBS Lett. 324:123-126

 

 

Redistribution of secretory granule components precedes that of synaptic vesicle proteins during differentiation of a neuronal cell line in serum-free medium.
Wheatley SC, Suburo AM, Horn D, Vucicevic V, Terenghi G, Polak JM and Latchman DS. (1992) Neuroscience. 51:575-582

 

 

Expression of the tissue specific splicing protein SmN in neuronal cell lines and in regions of the brain with different splicing capacities.
Horn D, Suburo A, Terenghi G, Hudson L, Polak JM and Latchman DS. (1992) Brain Res: Mol. Brain Res. 19:13-19

 

 

Intracellular redistribution of neuropeptides and secretory proteins during differentiation of neuronal cell lines.
Suburo AM, Wheatley SC, Horn D, Gibson SJ, Jahn R, Fischer-Colbrie R, Wood JN, Latchman DS and Polak JM. (1992) Neuroscience. 46:881-889

 

 

Neuronal expression of the tissue specific splicing protein SmN and its possible role in pre mRNA splicing.
Horn D and Latchman DS. (1992) Biochem. Soc. Trans. 20:266s