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Ciulli Laboratory
School of Life Sciences, University of Dundee
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Alessio Ciulli
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Targeted Protein Degradation: PROTACs
Cullin RING E3 Ubiquitin Ligases
Chromatin-Reader Domains
Fragment-Based Ligand Discovery
Chemical Probes
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October 2021
Introducing BromoTAG and AGB1: our new inducible degron system for potent, rapid, selective protein degradation
New openings and website now live for our newly-announced Centre for Targeted Protein Degradation (CeTPD)
Lab contributing to Dundee being ranked top 6 in UK for spinout success
July 2021
Our beginner’s guide to PROTACs and targeted protein degradation is now out in The Biochemist
Successful anti-cancer alliance extended
New pre-print: Amide-to-ester substitution as a strategy for optimizing PROTAC permeability and cellular activity
June 2021
New preprint: Estimating the cooperativity of PROTAC-induced ternary complexes using 19F NMR displacement assay
April 2021
First-of-its-kind centre to lead protein degradation revolution
New pre-print: VHL inhibitor binding increases intracellular level of VHL
March 2021
Will and Manfred's review on the present and future of PROTACs for cancer therapy is now out in Current Opinion in Pharmacology
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