Alessio Ciulli is currently a Professor of Chemical Structural Biology and Principal Investigator at the School of Life Sciences, University of Dundee.
Alessio graduated Magna Cum Laude in Chemistry from the University of Florence in 2002. His final year Laurea project was in computational drug design and NMR spectroscopy of matrix zinc metalloproteases with the late Professor Ivano Bertini at the Magnetic Resonance Center (CERM).
In 2002 he was awarded a Gates Cambridge Scholarship to study at Cambridge. His PhD research, under the supervision of Professor Chris Abell and in collaboration with Dr Glyn Williams's biophysics team at Astex Pharmaceuticals, concerned with biophysical and structural studies of protein-ligand interactions and enzyme mechanism.
In 2006 he was awarded a College Research Fellowship to conduct post-doctoral research on biophysical fragment screening and fragment-based drug design, within the framework of two international consortia to develop new drugs against tuberculosis funded by the Bill & Melinda Gates Foundation and the European Union FP6, jointly directed by Professor Abell and Professor Sir Tom Blundell. A short Human Frontier Science Program (HFSP) Fellowship allowed Alessio to visit Yale University in February 2009 and initiate collaboration with Professor Craig Crews on structure-based design of small molecule inducers of intracellular protein degradation (PROTACs) targeting the von Hippel-Lindau protein (VHL). He returned to Cambridge in June 2009 to start his independent research career as a BBSRC David Phillips Fellow within the Department of Chemistry.
In 2013 Alessio was awarded an ERC Starting Grant and moved his laboratory to Dundee where he took up a Readership (Associate Professorship) in Chemical & Structural Biology as Principal Investigator within the Division of Biological Chemistry and Drug Discovery of the School of Life Sciences. He was promoted to Professor (Chair) in October 2016.
Research in the Ciulli laboratory focuses on developing small molecules targeting protein-protein interactions and inducing targeted protein degradation.
Honours and Awards
- 2016 Fellow of the Royal Society of Chemistry (FRSC)
- 2016 MedChemComm Emerging Investigator Lectureship
- 2016 RSC Capps Green Zomaya Award
- 2015 ICBS Young Chemical Biologist Award
- 2015 EFMC Prize for Young Medicinal Chemist in Academia
- 2014 Talented Young Italians Award (Research and Innovation)
- 2012 ERC Starting Grant
- 2009 BBSRC David Phillips Fellowship