Wellcome Trust Centre for Gene Regulation and Expression

Publications 2011

Ahmad, Y., Boisvert, F. M., Lundberg, E., Uhlen, M. and Lamond, A. I. (2011) Systematic analysis of protein pools, isoforms and modifications affecting turnover and subcellular localisation. Molecular and Cellular Proteomics.  Oct 16  [Epub ahead of print]  PMID:22002106 View Paper

Albert, B., Leger-Silvestre, I., Normand, C., Ostermaier, M. K., Perez-Fernandez, J., Panov, K. I., Zomerdijk, J. C., Schultz, P. and Gadal, O. (2011) RNA polymerase I-specific subunits promote polymerase clustering to enhance the rRNA gene transcription cycle. The Journal of Cell Biology 192, (2) 277-293  PMID:21263028 View Paper

Blow, J. J.,Ge, X. Q. and Jackson, D. A. (2011) How dormant origins promote complete genome replication. Trends in Biochemical Sciences 36, (8) 405-414  PMID:21641805 View Paper

Boisvert, F. M., Ahmad, Y., Gierlinski, M., Charriere, F., Lamond, D., Scott, M., Barton, G. J. and Lamond, A. I. (2011) A quantitative spatial proteomics analysis of proteome turnover in human cells. Molecular and Cellular Proteomics. Dec 1 [Epub ahead of print]  PMID:21937730 View Paper

Bowman, A., Ward, R., Wiechens, N., Singh, V., El-Mkami, H., Norman, D. G. and Owen-Hughes, T. (2011) The histone chaperones Nap1 and Vps75 bind histones H3 and H4 in a tetrameric conformation. Molecular Cell 41, (4) 398-408  PMID:21329878 View Paper

Bruderer, R., Tatham, M. H., Plechanovova, A., Matic, I., Garg, A. K. and Hay, R. T. (2011) Purification and identification of endogenous polySUMO conjugates. EMBO Reports 12, (2) 142-148  PMID:21252943 View Paper

Culver, C., Melvin, A., Mudie, S. and Rocha, S. (2011) HIF-1alpha depletion results in SP1-mediated cell cycle disruption and alters the cellular response to chemotherapeutic drugs. Cell Cycle 10, (8) 1249-1260  PMID:21412054 View Paper

Dellago, H., Loscher, M., Ajuh, P., Ryder, U., Kaisermayer, C., Grillari-Voglauer, R., Fortschegger, K., Gross, S., Gstraunthaler, A., Borth, N., Eisenhaber, F., Lamond, A. I. and Grillari, J. (2011) Exo70, a subunit of the exocyst complex, interacts with SNEV(hPrp19/hPso4) and is involved in pre-mRNA splicing. Biochemical Journal 438, (1) 81-91  PMID:21639856 View Paper

Drakou, C. E., Malekkou, A., Hayes, J. M., Lederer, C. W., Leonidas, D. D., Oikonomakos, N. G., Lamond, A. I., Santama, N. and Zographos, S. E. (2011) hCINAP is an atypical mammalian nuclear adenylate kinase with an ATPase motif: Structural and functional studies. Proteins 80, (1) 206-220  PMID:22038794 View Paper

Edmonds, E., Barton, G. J, Buisson, S., Francis, N., Gotch, F., Game, L., Haddad, M., Dinneen, M. and Bunker, C. (2011) Gene expression profiling in male genital lichen sclerosus. International Journal of Experimental Pathology 92, (5) 320-325  PMID:21718371 View Paper

Flaus, A. and Owen-Hughes, T. (2011) Mechanisms for ATP-dependent chromatin remodelling: the means to the end. Febs Journal 278, (19) 3579-3595  PMID:21810178 View Paper

Franz, A., Orth, M., Pirson, P. A., Sonneville, R., Blow, J. J., Gartner, A., Stemmann, O. and Hoppe, T. (2011) CDC-48/p97 Coordinates CDT-1 Degradation with GINS Chromatin Dissociation to Ensure Faithful DNA Replication. Molecular Cell 44, (1) 85-96  PMID:21981920 View Paper

Gambus, A., Khoudoli, G. A., Jones, R. C. and Blow, J. J. (2011) MCM2-7 form double hexamers at licensed origins in Xenopus egg extract. The Journal of Biological Chemistry 286, (13) 11855-11864  PMID:21282109 View Paper

Gandhi, S. R., Gierlinski, M., Mino, A., Tanaka, K., Kitamura, E., Clayton, L. and Tanaka, T. U. (2011) Kinetochore-dependent microtubule rescue ensures their efficient and sustained interactions in early mitosis. Developmental Cell 21, (5) 920-933  PMID:22075150 View Paper

Gkikopoulos, T., Schofield, P., Singh, V., Pinskaya, M., Mellor, J., Smolle, M., Workman, J. L., Barton, G. J. and Owen-Hughes, T. (2011) A role for Snf2-related nucleosome-spacing enzymes in genome-wide nucleosome organization. Science 333, (6050) 1758-1760  PMID:21940898 View Paper

Gkikopoulos, T., Singh, V., Tsui, K., Awad, S., Renshaw, M. J., Scholfield, P., Barton, G. J., Nislow, C., Tanaka, T. U. and Owen-Hughes, T. (2011) The SWI/SNF complex acts to constrain distribution of the centromeric histone variant Cse4. Embo Journal 30, (10) 1919-1927  PMID:21505420 View Paper

Hattersley, N., Shen, L., Jaffray, E. G. and Hay, R. T. (2011) The SUMO protease SENP6 is a direct regulator of PML nuclear bodies. Molecular Biology of the Cell 22, (1) 78-90 PMID:21148299 View Paper

Hutten, S., Prescott, A., James, J., Riesenberg, S., Boulon, S., Lam, Y. W. and Lamond, A. I. (2011) An intranucleolar body associated with rDNA. Chromosoma 120, (5) 481-499  PMID:21698343 View Paper

Klotz-Noack, K. and Blow, J. J. (2011) A role for dormant origins in tumor suppression. Molecular Cell 41, (5) 495-496  PMID:21362544 View Paper

Kubota, T., Hiraga, S., Yamada, K., Lamond, A. I. and Donaldson, A. D. (2011) Quantitative Proteomic Analysis of Chromatin Reveals that Ctf18 Acts in the DNA Replication Checkpoint. Molecular and Cellular Proteomics. 10, (7) M110 005561  PMID:21505101 View Paper

Kundu, L. R., Seki, M., Watanabe, N., Murofushi, H., Furukohri, A., Waga, S., Score, A., Blow, J. J., Horikoshi, M., Enomoto, T. and Tada, S. (2011) Biphasic chromatin binding of histone chaperone FACT during eukaryotic chromatin DNA replication. Biochima et Biophysica Acta 1813, (6) 1129-1136  PMID:21232560 View Paper

Larance, M., Bailly, A. P., Pourkarimi, E., Hay, R. T., Buchanan, G., Coulthurst, S., Xirodimas, D. P., Gartner, A. and Lamond, A. I. (2011) Stable-isotope labeling with amino acids in nematodes. Nature Methods 8, (10) 849-851  PMID:21874007 View Paper

Larance, M., Kirkwood, K. J., Xirodimas, D. P., Lundberg, E., Uhlen, M. and Lamond, A. I. (2011) Characterization of MRFAP1 Turnover and Interactions Downstream of theNEDD8 Pathway. Molecular and Cellular Proteomics Oct 29 [epub ahead of print]  PMID:22038470 View Paper

Lejeune, E., Bayne, E. H. and Allshire, R. C. (2011) On the connection between RNAi and heterochromatin at centromeres. Cold Spring Harbor Symposia on Quantitative Biology 75, 275-283  PMID:21289046 View Paper

Matic, I., Jaffray, E. G., Oxenham, S. K., Groves, M. J., Barratt, C. L., Tauro, S., Stanley-Wall, N. R. and Hay, R. T. (2011) Absolute SILAC-Compatible Expression Strain Allows Sumo-2 Copy Number Determination in Clinical Samples. Journal of Proteome Research 10, (10) 4869-4875  PMID:21830832 View Paper

Maure, J. F., Komoto, S., Oku, Y., Mino, A., Pasqualato, S., Natsume, K., Clayton, L., Musacchio, A. and Tanaka, T. U. (2011) The Ndc80 loop region facilitates formation of kinetochore attachment to the dynamic microtubule plus end. Current Biology 21, (13) 207-213  PMID:21256019 View Paper

Mauro, C., Leow, S. C., Anso, E., Rocha, S., Thotakura, A. K., Tornatore, L., Moretti, M., De Smaele, E., Beg, A. A., Tergaonkar, V., Chandel, N. S. and Franzoso, G. (2011) NF-kappaB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration. Nature Cell Biology 13, (10) 1272-1279  PMID:21968997 View Paper

Mehrotra, P. V., Ahel, D., Ryan, D. P., Weston, R., Wiechens, N., Kraehenbuehl, R., Owen-Hughes, T. and Ahel, I. (2011) DNA repair factor APLF is a histone chaperone. Molecular Cell 41, (1)46-55  PMID:21211722 View Paper

Melvin, A., Mudie, S. and Rocha, S. (2011) The chromatin remodeler ISWI regulates the cellular response to hypoxia: role of FIH. Molecular Biology of the Cell 22, (21) 4171-4181 PMID:21900490 View Paper

Melvin, A., Mudie, S. and Rocha, S. (2011) Further insights into the mechanism of hypoxia-induced NFkappaB. [corrected]. Cell Cycle 10, (6) 879-882  PMID:21325892 View Paper

Moore, H. C., Johnston, M., Nicol, S. M., Bourdon, J. C., Thompson, A. M., Hutvagner, G. and Fuller-Pace, F. V. (2011) An evolutionarily conserved, alternatively spliced, intron in the p68/DDX5 DEAD-box RNA helicase gene encodes a novel miRNA. RNA 17, (4) 555-562  PMID:21346006 View Paper

Moser, S. C. and Swedlow, J. R. (2011) How to be a mitotic chromosome. Chromosome Research. 19, (3) 307-319  PMID:21461697 View Paper

Msaki, A., Sanchez, A. M., Koh, L. F., Barre, B., Rocha, S., Perkins, N. D. and Johnson, R. F. (2011) The role of RelA (p65) threonine 505 phosphorylation in the regulation of cell growth, survival, and migration. Molecular Biology of the Cell 22, (17) 3032-3040  PMID:21737676 View Paper

Naidu, S., Friedrich, J. K., Russell, J. and Zomerdijk, J. C. (2011) TAF1B is a TFIIB-like component of the basal transcription machinery for RNA polymerase I. Science 333, (6049) 1640-1642  PMID:21921199 View Paper

Napolitano, L. M., Jaffray, E. G., Hay, R. T. and Meroni, G. (2011) Functional interactions between ubiquitin E2 enzymes and TRIM proteins. Biochemical Journal 434, (2) 309-319 PMID:21143188 View Paper

Nathke, I. and Rocha, S. (2011) Antagonistic crosstalk between APC and HIF-1alpha. Cell Cycle 10, (10) 1545-1547  PMID:21502812 View Paper

Ono, M., Scott, M. S., Yamada, K., Avolio, F., Barton, G. J. and Lamond, A. I. (2011) Identification of human miRNA precursors that resemble box C/D snoRNAs. Nucleic Acids Research 39, (9) 3879-3891  PMID: 21247878 View Paper

Overton, I. M. and Barton, G. J. (2011) Computational approaches to selecting and optimising targets for structural biology. Methods 55, (1) 3-11  PMID:21906678 View Paper

Overton, I. M., Graham, S., Gould, K. A., Hinds, J., Botting, C. H., Shirran, S., Barton, G. J. and Coote, P. J. (2011) Global network analysis of drug tolerance, mode of action and virulence in methicillin-resistant S. aureus. BMC Systems Biology May 12. 5, 68  PMID:21569391 View Paper

Overton, I. M., van Niekerk, C. A. and Barton, G. J. (2011) XANNpred: neural nets that predict the propensity of a protein to yield diffraction-quality crystals. Proteins 79, (4) 1027-1033  PMID:21246630 View Paper

Plechanovova, A., Jaffray, E. G., McMahon, S. A., Johnson, K. A., Navratilova, I., Naismith, J. H. and Hay, R. T. (2011) Mechanism of ubiquitylation by dimeric RING ligase RNF4. Nature Structural and Molecular Biology 18, (9) 1052-1059  PMID:21857666 View Paper

Pourkarimi, E., Greiss, S. and Gartner, A. (2011) Evidence that CED-9/Bcl2 and CED-4/Apaf-1 localization is not consistent with the current model for C. elegans apoptosis induction. Cell Death and Differerentiation Sep 2. [Epub ahead of print]  PMID:21886181 View Paper

Rhind, N., Chen, Z., Yassour, M., Thompson, D. A., Haas, B. J., Habib, N., Wapinski, I., Roy, S., Lin, M. F., Heiman, D. I., Young, S. K., Furuya, K., Guo, Y., Pidoux, A., Chen, H. M., Robbertse, B., Goldberg, J. M., Aoki, K., Bayne, E. H., Berlin, A. M., Desjardins, C. A., Dobbs, E., Dukaj, L., Fan, L., FitzGerald, M. G., French, C., Gujja, S., Hansen, K., Keifenheim, D., Levin, J. Z., Mosher, R. A., Muller, C. A., Pfiffner, J., Priest, M., Russ, C., Smialowska, A., Swoboda, P., Sykes, S. M., Vaughn, M., Vengrova, S., Yoder, R., Zeng, Q., Allshire, R., Baulcombe, D., Birren, B. W., Brown, W., Ekwall, K., Kellis, M., Leatherwood, J., Levin, H., Margalit, H., Martienssen, R., Nieduszynski, C. A., Spatafora, J. W., Friedman, N., Dalgaard, J. Z., Baumann, P., Niki, H., Regev, A. and Nusbaum, C. (2011) Comparative functional genomics of the fission yeasts. Science 332, (6032) 930-936  PMID:21511999 View Paper

Rutkowski, R., Dickinson, R., Stewart, G., Craig, A., Schimpl, M., Keyse, S. M. and Gartner, A. (2011) Regulation of Caenorhabditis elegans p53/CEP-1-dependent germ cell apoptosis by Ras/MAPK signaling. PLoS Genetics 7, (8) e1002238  PMID:21901106 View Paper

Ryan, D. P. and Owen-Hughes, T. (2011) Snf2-family proteins: chromatin remodellers for any occasion. Current Opinion Chemical Biology 15, (5) 649-656  PMID:21862382 View Paper

Ryan, D. P., Sundaramoorthy, R., Martin, D., Singh, V. and Owen-Hughes, T. (2011) The DNA-binding domain of the Chd1 chromatin-remodelling enzyme contains SANT and SLIDE domains. Embo Journal 30, (13) 2596-2609  PMID:21623345 View Paper

Sasaki, T., Li, A., Gillespie, P. J., Blow, J. J. and Gilbert, D. M. (2011) Evidence for a mammalian late-G1 phase inhibitor of replication licensing distinct from geminin or Cdk activity. Nucleus 2, (5) 455-464  PMID:21983086 View Paper

Scott, M. S., Boisvert, F. M., Lamond, A. I. and Barton, G. J. (2011) PNAC: a protein nucleolar association classifier. BMC Genomics 12, 74  PMID:21272300 View Paper

Scott, M. S., Troshin, P. V. and Barton, G. J. (2011) NoD: a Nucleolar localization sequence detector for eukaryotic and viral proteins. BMC Bioinformatics 12, 317  PMID:21812952 View Paper

Simoes, M. J., Gartner, A., Shirosaki, Y., Gil da Costa, R. M., Cortez, P. P., Gartner, F., Santos, J. D., Lopes, M. A., Geuna, S., Varejao, A. S. and Mauricio, A. C. (2011) In vitro and in vivo chitosan membranes testing for peripheral nerve reconstruction. Acta Medica Portuguesa 24, (1) 43-52  PMID:21672441 View Paper

Sugden, C., Ross, S., Annesley, S. J., Cole, C., Bloomfield, G., Ivens, A., Skelton, J., Fisher, P. R., Barton, G. J. and Williams, J. G. (2011) A Dictyostelium SH2 adaptor protein required for correct DIF-1 signaling and pattern formation. Developmental Biology 353, (2) 290-301  PMID:21396932 View Paper

Swedlow, J. R.(2011) Finding an image in a haystack: the case for public image repositories. Nature Cell Biology 13, 183  PMID:21364564 View Paper

Swedlow, J. R., Zanetti, G. and Best, C. (2011) Channeling the data deluge. Nature Methods 8, (6) 463-465  PMID:21623351 View Paper

Tatchell, K., Makrantoni, V., Stark, M. J. and Robinson, L. C. (2011) Temperature-sensitive ipl1-2/Aurora B mutation is suppressed by mutations in TOR complex 1 via the Glc7/PP1 phosphatase. Proceedings of the National Academy of Sciences of the U S A. 108, (10) 3994-3999  PMID:21368139 View Paper

Tatham, M. H., Matic, I., Mann, M. and Hay, R. T. (2011) Comparative Proteomic Analysis Identifies a Role for SUMO in Protein Quality Control. Science Signaling 4, (178) rs4 PMID:21693764 View Paper

ten Have, S., Boulon, S., Ahmad, Y. and Lamond, A. I. (2011) Mass spectrometry-based immuno-precipitation proteomics - the user's guide. Proteomics 11, (6) 1153-1159  PMID:21365760 View Paper

Troshin, P. V., Postis, V. L., Ashworth, D., Baldwin, S. A., McPherson, M. J. and Barton, G. J. (2011) PIMS sequencing extension: a laboratory information management system for DNA sequencing facilities. BMC Research Notes 4, 48  PMID:21385349 View Paper

Troshin, P. V., Procter, J. B. and Barton, G. J. (2011) Java bioinformatics analysis web services for multiple sequence alignment--JABAWS:MSA. Bioinformatics 27, (14) 2001-2002 PMID:21593132 View Paper

van Uden, P., Kenneth, N. S., Webster, R., Muller, H. A., Mudie, S. and Rocha, S. (2011) Evolutionary conserved regulation of HIF-1beta by NF-kappaB. PLoS Genetics 7, (1) e1001285  PMID:21298084 View Paper

Wang, X. D., Lapi, E., Sullivan, A., Ratnayaka, I., Goldin, R., Hay, R. T. and Lu, X. (2011) SUMO-modified nuclear cyclin D1 bypasses Ras-induced senescence. Cell Death and Differerentiation 18, (2) 304-314 PMID:20798689 View Paper

Westman, B. J. and Lamond, A. I. (2011) A role for SUMOylation in snoRNP biogenesis revealed by quantitative proteomics. Nucleus 2, (1) 30-37 PMID:21647297 View Paper