University of Dundee

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Biological networks: interdisciplinary collaboration sheds light on what makes cells robust

A collaboration between two interdisciplinary research groups at the University of Dundee has led to a better understanding of how cells are able to maintain their stability and function in response to environmental challenges and potential threats. 

The laboratories of Professors Julian Blow and Tim Newman have published a paper showing how a cell’s gene regulatory network – the system that allows a cell to produce the right set of proteins in response to external and internal environmental triggers – is wired up to maintain its stability. 

CLS Researchers make drug discovery breakthrough

The potential to develop new drugs to target a class of enzymes implicated in major diseases such as cancer and neurodegenerative conditions has been boosted with the development of a new drug discovery method in a research effort led by the University of Dundee.
The research group have been examining the class of enzymes called deubiquitylases (DUBs). Around 90 DUBs have been identified in the human genome and they are active in almost every process in cells.

CLS research reveals how key controller protein is switched on

New research has uncovered how a complex protein pivotal in the development of cancer, viral infection and autoimmune diseases is activated. The discovery answers a key question about one of the most widely-researched proteins in human biology, which has been the subject of tens of thousands of research papers and millions of pounds in research funding.

Horn Lab collaboration with Sussex reveals novel DNA repair polymerase

Researchers from David Horn's lab working with colleagues at the University of Sussex, have made a breakthrough in our understanding of how enzymes that make DNA, complete genome replication. Scientists studied a pair of primase polymerase-like (PPL) enzymes in the African trypanosome, a protozoan parasite that causes important diseases of humans and animals. These enzymes are also found in mammalian cells and many other eukaryotes.

Dundee-Glasgow collaboration shows that sleeping sickness parasite’s pores act as efficient drug uptake mechanism

Scientists at the Universities of Dundee and Glasgow have discovered how drugs that have been used for 60 years to kill the parasite that causes sleeping sickness actually work.

Research has revealed that the drugs used to attack Trypanosoma brucei enter through pores in the parasite’s cells known as aquaporins which function as water channels.

It is the first time that drugs have been shown to enter cells through aquaporins and this may have major implications for drug delivery in other diseases.

CLS researchers identify protein which could be a key in cancer research

Scientists at the College of Life Sciences at the University of Dundee have identified a protein that could be key in the fight against cancer.

Researchers at the College's Centre for Gene Regulation and Expression have demonstrated that cancer cells need a protein called Bod1 to grow and divide. When this protein is removed cancer cells lose control of cell division and die.

CLS collaboration reveals arsenic water contamination is implicated in resistance to Leishmaniasis drug in India

Arsenic contamination of water supplies may have played a significant role in the development of widespread resistance in the Indian subcontinent to an important drug used to treat leishmaniasis, the second-largest parasitic killer in the world.

Visceral leishmaniasis infects around half a million people across the world every year and close to one-in-ten of those die.