University of Dundee

"Investigating how mechanical forces control cell divisions: from the Drosophila epithelium to migrating neural crest cells"

Event Date: 
Thursday, January 23, 2020 - 14:00
Event Location: 
CTIR Sir Kenneth and Lady Noreen Murray Seminar Room . CTIR 284 - Discovery Centre
Host: 
Professor Kate Storey FRSE FMedSci FRSB
Event Speaker: 
Dr Elena Scarpa
Institution: 
University of Cambridge
Event Type: 
Seminar
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I did my PhD with Roberto Mayor at UCL, where my main project showed how a switch between E- and N- Cadherin drives the acquisition of contact inhibition of locomotion and leads to the redistribution of forces from intercellular junctions to cell-matrix adhesions in Xenopus and Zebrafish neural crest cells (Scarpa et al., Dev Cell 2015, https://doi.org/10.1016/j.devcel.2015.06.012 . I changed models for my postdoc, joining to Bénédicte Sanson’s group at the University of Cambrige, where I worked on the role of actomyosin-driven tension in orienting cell divisions in the Drosophila embryo. My latest paper in December 2018 demonstrated that cell divisions can be oriented by tension independently of cell shape in the embryonic epithelium in vivo (Scarpa et al., Dev Cell 2018, https://doi.org/10.1016/j.devcel.2018.10.029).