University of Dundee

"Regeneration and patterning of limbs, fins and tails"

Event Date: 
Friday, January 31, 2020 - 14:00
Event Location: 
Wellcome Trust Building Seminar Rooms WTB-SRF and WTB-SRB
Host: 
Professor Kate Storey FRSE FMedSci FRSB
Event Speaker: 
Dr Tom Hiscock
Institution: 
Cancer Research UK Cambridge Institute University of Cambridge
Event Type: 
Seminar
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There is an incredible diversity in the morphology and function of vertebrate appendages, which include limbs, fins and tails. Moreover, there is a large variation in the ability of different species to regenerate these appendages. In the first part of my talk, I will describe appendage regeneration in tadpoles of the frog species, Xenopus laevis, which can regenerate both limbs and tails but only at early stages. Using single cell RNA sequencing, we discovered a previously unrecognized cell type in the tail that organizes the regenerative response, and find a similar cell type at work in the limb. In the second part of my talk, I will explain how we have used mathematical modelling to understand limb patterning, and provide a new hypothesis to explain joint patterns and morphologies across the tetrapod lineage.
 
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