University of Dundee

“Comparative transcriptomics identifies a single SNP mutation that controls virulence of African Salmonella"

Event Date: 
Tuesday, February 4, 2020 - 13:30
Event Location: 
CTIR Sir Kenneth and Lady Noreen Murray Seminar Room . CTIR 284 - Discovery Centre
Host: 
Professor Sarah Coulthurst
Event Speaker: 
Professor Jay Hinton
Institution: 
University of Liverpool
Event Type: 
Seminar
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Abstract:
 
With 3.4 million infections each year, invasive non-Typhoidal Salmonella (iNTS) is a major cause of illness worldwide. In Sub-Saharan Africa bloodstream infections with iNTS Salmonella enterica serovar Typhimurium are causing ~68,000 deaths annually. Co-infection with HIV or malaria in adults, and a young age (<5 years) are known risk factors.
Using a combination of comparative genomics and comparative transcriptomics, we discovered phenotypic differences that distinguish African from global Salmonella pathovariants (Canals et al., 2019).
Our analysis led us to identify a single core genome SNP responsible for the up-regulation of a single promoter in strain D23580 that controlled the expression of a Salmonella virulence factor (Hammarlöf et al., 2018), and offers part of the explanation of the pan-African epidemic of bloodstream infection. All of the Salmonella transcriptomic data we have generated are now available online in a user-friendly website that allows intra-strain and inter-strain comparisons of gene expression between African and global pathovariants of S. Typhimurium: https://tinyurl.com/SalComD23580