University of Dundee

"Sex Differences in Organ Plasticity"

Event Date: 
Tuesday, November 26, 2019 - 12:00
Event Location: 
School of Life Sciences, MSI Small Lecture Theatre
Host: 
Professor Victoria Cowling FRSE FRSB
Dr Jens Januschke
Event Speaker: 
Irene Miguel-Aliaga
Institution: 
Professor of Genetics and Physiology (Imperial College London) and Section Chair/Programme Leader (MRC LMS)
Event Type: 
Seminar
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Joint GRE & CDB External Seminar

 

Abstract: 

Internal organs constantly exchange signals, and can respond with striking anatomical and functional transformations, even in fully developed organisms. We are exploring the mechanisms that drive and sustain such plasticity using the intestine and its neurons as experimental systems. I will present some of our recent work, which has explored the physiological plasticity of the intestinal epithelium using Drosophila, focusing on both stem cells and their progeny: the digestive/absorptive enterocytes. This has revealed unexpected sexual dimorphisms and intestinal contributions to reproductive success. I will discuss our ongoing work on how and why testes selfishly masculinize the metabolism of gut cells, as well as our attempts to explore how broadly applicable our findings may be using mouse and human models.