‘Regulation of Innate Lymphoid Cell responses and host-microbiota crosstalk at mucosal barrier sites’
Monday, July 22, 2019 - 15:00 to 16:00
CTIR Sir Kenneth and Lady Noreen Murray Seminar Room
Dr Linda Sinclair
Dr Matthew Hepworth
University of Manchester
Tissue homeostasis within the gastrointestinal tract requires crosstalk between the host immune system and a range of environmental stimuli derived from the diet and microbiota. In particular, interactions between innate and adaptive immune cells act to prevent inappropriate inflammatory responses against microbial and dietary antigens and to maintain tissue health. Innate lymphoid cells (ILC) are a family of innate “sentinels” that constitutively reside in the mucosal barrier tissues, including the gut, and respond rapidly to damage and infection. Moreover, ILC are increasingly appreciated to be key orchestrators of tissue immune responses through regulatory crosstalk with myeloid and adaptive immune cell populations. In addition, the intestinal environment acts to modulate and facilitate intestinal immune responses through provision of critical metabolites and nutrients required to tune appropriate immune function. Emerging evidence suggests ILC respond to microbial metabolites and that ILC effector function is tightly controlled by the import of nutrients and metabolic substrates, which are subsequently required to license effector function. Together these findings suggest a dynamic crosstalk between diet, microbiota and intestinal ILC which together act to maintain tissue health and prevent inflammatory responses.