University of Dundee

"The Source of Dietary Fat Shapes the Anti-Cancer Immune Response in Obesity"

Event Date: 
Wednesday, June 19, 2019 - 13:00 to 14:00
Event Location: 
CTIR Sir Kenneth and Lady Noreen Murray Seminar Room
Dr Linda Sinclair
Event Speaker: 
Dr Róisín Loftus
School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute
Event Type: 

All Welcome


Obesity causes a severe metabolic and functional defect in the anti-cancer responses of Natural Killer (NK) cells, which may contribute to the increased incidence of cancer in obesity. However, little is currently known about how dietary choices shape the metabolic landscape of immune cells in obesity.

To investigate how diet shapes NK cell immune responses, we fed mice a High Fat Diet (HFD) (45%) from different fat sources including plant, dairy, animal and nut based HFD. We then challenged the mice with B16 melanoma cancer and measured differences in tumor progression and NK infiltration. Interestingly, despite similar adiposity between different HFD fed mice, certain high fat diets accelerated tumor growth, as expected, but surprisingly, some high fat diets did not affect tumor growth or NK cell metabolism compared to Standard Fat Diet (SFD). Feeding, diet absorption and systemic metabolic disorder did not account for the differences observed. We have now adopted a multi-omics approach (proteomics and metabolomics) to investigate the differential effects of dietary fats on systemic and intracellular (immune cell and cancer) metabolism. The research will contribute to our understanding of how dietary nutrients shape immune surveillance.