University of Dundee

‘Control of membrane traffic at the Golgi by coiled-coil proteins and Rab GTPases’

Event Date: 
Monday, March 18, 2019 - 13:00
Event Location: 
MSI Small Lecture Theatre
Host: 
Professor Dario Alessi FRS FRSE
Event Speaker: 
Dr Sean Munro
Institution: 
MRC-LMB
Event Type: 
Seminar
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Bio:

PhD with Hugh Pelham at the MRC-LMB in Cambridge UK.  Development of epitope tagging, identification of a member of the hsp70 family of chaperones in the ER,  discovery of the KDEL sequence for retention of proteins in the ER.  

 

Post-doc with Tom Maniatis in Harvard.   Cloning of the receptor for gamma interferon.

 

Group leader in the Division of Cell Biology in the MRC LMB (tenure-track and then tenured, and since 2012 Head of the Cell Biology Division).  Mostly focused on membrane traffic and the Golgi apparatus, but also cloned the CB2 cannabinoid receptor along the way (my most highly cited paper).  Areas covered included role of transmembrane domains in protein sorting,  role of PtdIns(4)P as a Golgi targeting signal,  role of GTPases in recruiting proteins to the Golgi, role of golgin coiled-coil proteins as vesicle tethers at the Golgi.