University of Dundee

‘Enhancing the therapeutic potential of cytokines through protein engineering’

Event Date: 
Friday, October 18, 2019 - 14:00
Event Location: 
Sir Kenneth and Lady Noreen Murray Seminar Room School of Life Sciences, Discovery Centre (CTIR 2.84)
Dr. Ignacio Moraga Gonzalez
Event Speaker: 
Dr Juan Mendoza
University of Chicago Pritzker School of Molecular Engineering and Dept. of Biochemistry and Molecular Biology
Event Type: 

All Welcome



The interferon (IFN) superfamily of cytokines is an essential part of the innate immune system which protects against the spread of viral infections and cancerous growths. There are three families of IFNs, type I-III, each with distinct ligand-receptor systems. This presentation will report on efforts to elucidate the structure-functional relationships of IFN induced signaling and to enhance IFN functions. For these efforts, a protein engineering approach has been applied to rapidly evolve IFNs and visualize the three-dimensional shapes of interferon cytokines bound to their cellular receptors. These results provide new insight into cytokine signaling and new opportunities for developing promising molecules for basic research and clinical use.