University of Dundee

‘Cellular responses to DNA damage: mechanistic insights and applications in cancer therapy’

Event Date: 
Tuesday, November 13, 2018 - 13:00 to 14:00
Event Location: 
MSI Small Lecture Theatre
Host: 
Professor John Rouse FRSE
Event Speaker: 
Prof Steve Jackson FRS, FMedSci
Institution: 
University of Cambridge
Event Type: 
Seminar
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Steve Jackson is a world leading figure in the study of DNA repair and DNA damage signalling. He is the Francis James Quick Professor of Biology at University of Cambridge, and Head of Cancer Research UK Laboratories at the Gurdon Institute. Research in Steve’s lab has identified many key principles by which cells respond to and repair DNA damage. Steve’s lab has identified many DNA repair proteins, established how they function, and helped define how their dysfunction yields cancer and other age-related diseases. Steve’s work has been recognized by a wide range of prestigious prizes, including the 2015 Gagna and van Heck Prize for Medicine, the 2016 King Faisal International Prize for Science, the 2016 AH. Heineken Prize for Medicine, and the 2017 Genome Stability Network Medal.
 
To translate his academic work towards patient benefit, in 1997 Steve founded the drug-discovery company KuDOS Pharmaceuticals Ltd., and he then served as part-time Chief Scientific Officer (CSO) until and after its acquisition by AstraZeneca in 2005. Several KuDOS-generated drugs are currently in clinical trials, with the most advanced, the PARP inhibitor olaparib/LynparzaTMnow being a marketed anti-cancer drug for certain ovarian and breast cancers throughout the world. In 2010, Steve founded Mission Therapeutics Ltd. (Babraham, Cambridge) to exploit recent advances in protein ubiquitylation and deubiquitylation to derive new medicines. Steve’s academic laboratory is currently further defining mechanisms of DNA repair and associated processes, with a view to identifying new therapeutic opportunities for cancer as well as various other genetic diseases.
 
Steve gives an excellent talks that will appeal to wide audience including those interested in cell signalling, chromatin, DNA repair, DNA replication, the molecular basis for disease and the development of new treatments for cancer. Please come early to be sure of getting a seat.