University of Dundee

‘The impact of macrophage phagocytosis in the modulation of inflammation resolution’

Event Date: 
Thursday, December 13, 2018 - 13:00 to 14:00
Event Location: 
WTB Seminar Rooms
Professor Paul Crocker FRSE
Event Speaker: 
Ioannis Kourtzelis
Dresden University
Event Type: 
Dundee Cell Signalling Lecture

Timely termination of an inflammatory response is of major importance to prevent unwarranted tissue damage and promote reconstitution of tissue integrity after inflammatory insults. Inflammation resolution does not represent passive termination of inflammatory responses but rather a well-coordinated active process. In this regard, after performing acute proinflammatory actions, recruited neutrophils in the inflamed site undergo apoptosis and are cleared by macrophage phagocytosis through a process known as efferocytosis. Several interactions between phagocytic receptors and specific ligands, involving among others effectors of complement pathways and integrin system, coordinate efferocytic activity. This process serves more than waste disposal as it promotes a ‘pro-resolving’ phenotype in macrophages that includes metabolic alterations. In this talk I will summarize our findings into the regulation of efferocytosis and show how this process promotes clearance of inflammation. Additionally, I will discuss potential ways to investigate the interconnections between immunometabolism and phagocytic activity that may lead to the identification of novel regulators of inflammation resolution.