During my studies at the ETH Zürich, I developed a fascination for microbes and their interactions with biotic and abiotic environments. I investigated the mechanism of bacterial protein N-glycosylation in the lab of Dr. Markus Aebi. I then joined the lab of Dr. Mario Feldman in Edmonton, Canada, to explore the biotechnological potential of this system by producing a medically relevant glycoprotein with combined genetic engineering and biochemistry approaches. Investigating the similarities between pathways of bacterial glyco-conjugates and describing the Helicobacter pylori LPS pathway were another focus of my PhD research. From studying the assembly of bacterial cell surface structures, I moved on to investigate the bacterial response to surface contact. As a postdoc in the group of Dr. Urs Jenal at the University of Basel, Switzerland, I uncovered the molecular mechanism of the tactile response in Caulobacter crescentus. These findings will be the core of my talk.