Nico Thoma’s group combines crystallography and cryo-electron microscopy to study large protein complexes that are implicated in human disease. Nico’s group has a particular focus on the roles of ubiquitin ligases in DNA repair and chromatin biology.
Nico studied biosynthetic enzymes with Peter Leadlay in Cambridge for his PhD thesis, before post-doctoral periods with Roger Goody and Ilme Schlichting at the Max-Planck Institute for Molecular Physiology in Dortmund, and Nico Pavletich at Memorial Sloan Kettering in New York. Nico then joined the Friedrich Miescher Institute in Basel in 2006 as a Junior Group Leader, and was promoted as a tenured Senior Group Leader in 2012. Nico was elected a member of EMBO in 2015.
Cavadini S, Fischer ES, Bunker RD, Potenza A, Lingaraju GM, Goldie KN, Mohamed WI, Faty M, Petzold G, Beckwith RE, Tichkule RB, Hassiepen U, Abdulrahman W, Pantelic RS, Matsumoto S, Sugasawa K, Stahlberg H, Thomä NH. Nature. 2016 Mar 31;531(7596):598-603. doi: 10.1038/nature17416.
Petzold G, Fischer ES, Thomä NH. Nature. 2016 Apr 7;532(7597):127-30. doi: 10.1038/nature16979. Epub 2016 Feb 24.
Fischer ES, Böhm K, Lydeard JR, Yang H, Stadler MB, Cavadini S, Nagel J, Serluca F, Acker V, Lingaraju GM, Tichkule RB, Schebesta M, Forrester WC, Schirle M, Hassiepen U, Ottl J, Hild M, Beckwith RE, Harper JW, Jenkins JL, Thomä NH. Nature. 2014 Aug 7;512(7512):49-53. doi: 10.1038/nature13527. Epub 2014 Jul 16.
Lingaraju GM, Bunker RD, Cavadini S, Hess D, Hassiepen U, Renatus M, Fischer ES, Thomä NH.Nature. 2014 Aug 14;512(7513):161-5. doi: 10.1038/nature13566. Epub 2014 Jul 16.
Joint MRC Protein Phosphorylation and Ubiquitylation, Centre for Gene Regulation & Expression and Biological Chemistry and Drug Discovery Seminar