University of Dundee

‘The CRL4 ubiquitin ligase: at the intersection of genome stability and drug discovery’

Event Date: 
Tuesday, August 21, 2018 - 12:00 to 13:00
Event Location: 
MSI Small Lecture Theatre
Host: 
Professor Alessio Ciulli FRSC
Professor Ron Hay FRS FRSE FMedSci
Professor Karim Labib FRSE
Event Speaker: 
Dr Nico Thoma
Institution: 
Friedrich Miescher Institute (FMI), Basel Switzerland
Event Type: 
Seminar
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Nico Thoma’s group combines crystallography and cryo-electron microscopy to study large protein complexes that are implicated in human disease.  Nico’s group has a particular focus on the roles of ubiquitin ligases in DNA repair and chromatin biology. 

 

Nico studied biosynthetic enzymes with Peter Leadlay in Cambridge for his PhD thesis, before post-doctoral periods with Roger Goody and Ilme Schlichting at the Max-Planck Institute for Molecular Physiology in Dortmund, and Nico Pavletich at Memorial Sloan Kettering in New York.  Nico then joined the Friedrich Miescher Institute in Basel in 2006 as a Junior Group Leader, and was promoted as a tenured Senior Group Leader in 2012.  Nico was elected a member of EMBO in 2015.

 

Selected publications:

 

Cullin-RING ubiquitin E3 ligase regulation by the COP9 signalosome.

Cavadini S, Fischer ES, Bunker RD, Potenza A, Lingaraju GM, Goldie KN, Mohamed WI, Faty M, Petzold G, Beckwith RE, Tichkule RB, Hassiepen U, Abdulrahman W, Pantelic RS, Matsumoto S, Sugasawa K, Stahlberg H, Thomä NHNature. 2016 Mar 31;531(7596):598-603. doi: 10.1038/nature17416.

 

Structural basis of lenalidomide-induced CK1α degradation by the CRL4(CRBN) ubiquitin ligase.

Petzold G, Fischer ES, Thomä NH. Nature. 2016 Apr 7;532(7597):127-30. doi: 10.1038/nature16979. Epub 2016 Feb 24.

 

Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide.

Fischer ES, Böhm K, Lydeard JR, Yang H, Stadler MB, Cavadini S, Nagel J, Serluca F, Acker V, Lingaraju GM, Tichkule RB, Schebesta M, Forrester WC, Schirle M, Hassiepen U, Ottl J, Hild M, Beckwith RE, Harper JW, Jenkins JL, Thomä NHNature. 2014 Aug 7;512(7512):49-53. doi: 10.1038/nature13527. Epub 2014 Jul 16.

 

Crystal structure of the human COP9 signalosome.

Lingaraju GM, Bunker RD, Cavadini S, Hess D, Hassiepen U, Renatus M, Fischer ES, Thomä NH.Nature. 2014 Aug 14;512(7513):161-5. doi: 10.1038/nature13566. Epub 2014 Jul 16.

 

Joint MRC Protein Phosphorylation and Ubiquitylation, Centre for Gene Regulation & Expression and Biological Chemistry and Drug Discovery Seminar