University of Dundee

'Ubiquitin Tips the Balance: How Proteostasis Is Challenged by Aging & Sensory Perception'

Event Date: 
Tuesday, September 18, 2018 - 12:00
Event Location: 
MSI Small Lecture Theatre
Host: 
Dr. Federico Pelisch
Event Speaker: 
Dr. Thorsten Hoppe
Institution: 
University of Cologne
Event Type: 
Seminar
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Abstract

Conjugation of ubiquitin onto proteins generates a degradation signal or exerts degradation-independent regulatory functions. Ubiquitylation is governed by the antagonistic action of ubiquitin ligases and deubiquitylating enzymes (DUBs). Several recent publications illustrate a balanced interplay of ligases and DUBs at signaling hubs central for longevity and protein homeostasis (proteostasis). In addition, stress-induced alterations of ubiquitin conjugation are emerging as key events that drive aging and contribute to the pathology of age-related diseases. This physiological role of dynamic ubiquitylation events further extends its well-known function in protein regulation and quality control at the cellular level. Recent work thus significantly advances our understanding of the aging process both at a molecular and organismal level.