MRC Protein Phosphorylation and Ubiquitylation Informal Seminar
Professor Shen received his MD degree from Zhejiang University in China followed by his PhD from the the National University of Singapore. His laboratory studies the mechanisms of autophagy in cancer and also the role of oxidative stress in cell death pathways. This has led him to investigate anti-oxidants and natural products as anti-cancer agents. He has published over 150 papers and has an h-index of 73.
Mitophagy or the selective removal or mitochondria by autophagy is a major biological process linked to a number of human diseases including Parkinson's disease. Much is known on the role of the PINK1 kinase in the initiation of stress-evoked mitophagy through the generation of Phospho-ubiquitin and activation of the Parkin ubiquitin ligase. However, the reverse regulation of mitophagy is poorly studied. The Shen lab has recently investigated a newly identified long isoform of PTEN (PTEN-L) and found that this functions as a negative regulator of mitophagy, via phosphatase activity against Phospho-ubiquitin. This informal seminar will be of great interest to many in the School especially those working in signal transduction and cell biology.