University of Dundee

“PTEN-L as a novel protein phosphatase against Phospho-ubiquitin in suppression of mitophagy”

Event Date: 
Friday, August 3, 2018 - 13:00 to 14:00
Event Location: 
CTIR Sir Kenneth and Lady Noreen Murray Seminar Room
Dr Ian Ganley
Professor Miratul Muqit FRSE
Event Speaker: 
Professor Han-Ming Shen
Yong Loo Lin School of Medicine, National University of Singapore
Event Type: 

MRC Protein Phosphorylation and Ubiquitylation Informal Seminar




Professor Shen received his MD degree from Zhejiang University in China followed by his PhD from the the National University of Singapore. His laboratory studies the mechanisms of autophagy in cancer and also the role of oxidative stress in cell death pathways. This has led him to investigate anti-oxidants and natural products as anti-cancer agents. He has published over 150 papers and has an h-index of 73.


Seminar Synopsis

Mitophagy or the selective removal or mitochondria by autophagy is a major biological process linked to a number of human diseases including Parkinson's disease. Much is known on the role of the PINK1 kinase in the initiation of stress-evoked mitophagy through the generation of Phospho-ubiquitin and activation of the Parkin ubiquitin ligase. However, the reverse regulation of mitophagy is poorly studied. The Shen lab has recently investigated a newly identified long isoform of PTEN (PTEN-L) and found that this functions as a negative regulator of mitophagy, via phosphatase activity against Phospho-ubiquitin. This informal seminar will be of great interest to many in the School especially those working in signal transduction and cell biology.