Abstract: The sebaceous gland is a mammalian skin appendage that serves a wide range of functions, from thermoregulation to barrier formation. Its dysfunction is associated with an equally wide range of skin conditions, including highly frequent ones such as acne vulgaris, oily skin and atopic dermatitis. Thus, sebaceous gland biology is of considerable interest to medicine as well as to personal care.
Unfortunately, human sebaceous gland physiology remains poorly understood and our ability to intervene in its functioning is correspondingly limited. Mouse or other animal models are of limited use in changing this situation, as illustrated by the fact that mice do not develop acne. Thus, there is a need for in vitro and/or in vivo models that better reflect the physiology and pathology of the human sebaceous gland.
In my talk, I will discuss the state of the art in sebaceous gland models, and what my lab are doing to develop better ones.