University of Dundee

"Serine ADP-ribosylation signaling”

Event Date: 
Tuesday, March 19, 2019 - 12:00 to 13:00
Event Location: 
MSI Small Lecture Theatre
Host: 
Professor Ron Hay FRS FRSE FMedSci
Event Speaker: 
Dr Ivan Matic
Institution: 
Max Planck Institute for Biology of Ageing
Event Type: 
Seminar
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bstract:

 

ADP-ribosylation (ADPr) is a key player in many physiological and disease

conditions, best known for its role in the maintenance of genome stability.

Despite the biological and clinical importance of ADPr little is known about

the functional consequences of site-specific ADPr. With a first truly unbiased and unambiguous

mapping of ADPr sites, we uncovered Serine ADPr as a new type of histone

mark that responds to DNA damage. Shortly afterwards we described the

molecular basis of Ser-ADPr by showing that HPF1 changes PARP1

specificity toward serine. More recently we showed that Ser-ADPr is the primary residue for ADPr upon DNA damage and revealed an intriguing interplay of canonical histone marks, such as lysine acetylation and phosphorylation, with Ser-ADPr.