Friday, November 24, 2017 - 11:00
MSI Small Lecture Theatre
Professor Geoff Barton FRSE FRSB
Professor Doreen Cantrell CBE FRS FRSE FMedSci
Professor Omer Dushek
University of Oxford
Omer Dushek is a Sir Henry Dale Fellow & Associate Professor at the Sir William Dunn School of Pathology (University of Oxford) and his laboratory is funded by the Wellcome Trust & the Royal Society. His work is focused on understanding how the T cell receptor and other, "accessory", receptors control the T cell response using quantitative experiments and mathematical modelling.
T cells orchestrate immune responses crucial for the elimination of infections and cancers. They do this by initiating responses when their T cell surface receptors (TCRs) recognise these threats. It is now appreciated that a large number of other, “accessory”, receptors shape these responses. Despite extensive research into the underlying biochemistry, we have yet formulate canonical models of signalling that explain how T cells integrate receptor signalling into responses. Here, we present our on-going efforts to identify an effective minimal model of signalling that can explain the T cell response to a 1-million fold variation in antigen ligand dose and affinity. We show how this minimal phenotypic model can provide information on how accessory receptors integrate with TCR signalling to regulate the T cell response. The work offers a general method to study cellular responses that does not require full details of biochemical signalling pathways.