University of Dundee

“Impact of cytosine modifications in gene regulation and their role in haematological malignancies"

Event Date: 
Tuesday, July 18, 2017 - 12:00 to 13:00
Event Location: 
MSI Small Lecture Theatre
Host: 
Professor Tom Owen-Hughes FRSE
Event Speaker: 
Dr Kasper Rasmussen
Institution: 
Biotech Research and Innovation Centre, University of Copenhagen
Event Type: 
Seminar
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Abstract:

 

The vast majority of cytosines in a CG context in the mammalian genome are covalently modified by methylation (mC) or oxidized methylcytosine derivatives (5hmC, 5fC, and 5caC). The patterns of these modifications are highly cell type-specific and change dynamically during development and differentiation. Several components of the cellular machinery that maintain these epigenetic landscapes have been found to be mutated in cancer. In this seminar, I will give insights into the function of Ten-Eleven Translocation (TET) proteins in DNA methylation homeostasis and how genetic disruption of TET2 can promote oncogenic transformation of hematopoietic cells.