Friday, September 1, 2017 - 12:00 to 13:00
CTIR Sir Kenneth and Lady Noreen Murray Seminar Room
Professor Grahame Hardie FRS, FRSE, FMedSci
St Vincent's Institute of Medical Research, Melbourne, Australia
John Scott originally hails from Glasgow, and obtained a BSc in Biochemistry from Glasgow University. He joined the lab of Grahame Hardie as a PhD student in 1997, graduated in 2001, and after a brief interlude in Glasgow returned as a postdoc in Grahame’s lab until 2006, when he left to take up a position as a Senior Research Fellow in the group of Bruce Kemp in Melbourne. John had a successful time in Grahame’s lab, which included establishing the detailed recognition motif for downstream targets of AMPK [Scott et al (2002) J. Mol. Biol. 317:309], identifying the function of CBS repeats in the gamma subunits of AMPK and other proteins as regulatory binding sites for AMP and other adenosine-containing ligands, and showing that mutations in CBS repeats that cause several hereditary diseases affect that binding [Scott et al (2004) J. Clin. Invest. 113:274]. John has continued to work on the AMPK system in Melbourne [e.g. Scott et al (2008) Chem. Biol. 11:1220; Scott et al (2014) Chem. Biol. 21:619], but recently has become particularly interested in the regulation and physiological role of one of its upstream kinases, CaMKK2 [e.g. Scott et al (2015) Sci. Rep. 5:14436; O’Brien et al (2017) Sci. Rep. 7:43264]. The latter will be the topic of his seminar.