University of Dundee

'CaMKK2: More Than Just a Ca2+ Sensor'

Event Date: 
Friday, September 1, 2017 - 12:00 to 13:00
Event Location: 
CTIR Sir Kenneth and Lady Noreen Murray Seminar Room
Professor Grahame Hardie FRS, FRSE, FMedSci
Event Speaker: 
John Scott
St Vincent's Institute of Medical Research, Melbourne, Australia
Event Type: 


John Scott originally hails from Glasgow, and obtained a BSc in Biochemistry from Glasgow University. He joined the lab of Grahame Hardie as a PhD student in 1997, graduated in 2001, and after a brief interlude in Glasgow returned as a postdoc in Grahame’s lab until 2006, when he left to take up a position as a Senior Research Fellow in the group of Bruce Kemp in Melbourne. John had a successful time in Grahame’s lab, which included establishing the detailed recognition motif for downstream targets of AMPK [Scott et al (2002) J. Mol. Biol. 317:309], identifying the function of CBS repeats in the gamma subunits of AMPK and other proteins as regulatory binding sites for AMP and other adenosine-containing ligands, and showing that mutations in CBS repeats that cause several hereditary diseases affect that binding [Scott et al (2004) J. Clin. Invest. 113:274]. John has continued to work on the AMPK system in Melbourne [e.g. Scott et al (2008) Chem. Biol. 11:1220; Scott et al (2014) Chem. Biol. 21:619], but recently has become particularly interested in the regulation and physiological role of one of its upstream kinases, CaMKK2 [e.g. Scott et al (2015) Sci. Rep. 5:14436; O’Brien et al (2017) Sci. Rep. 7:43264]. The latter will be the topic of his seminar.