University of Dundee

The University of Dundee is one of the leading universities in Europe for research in Life Sciences. In the most recent UK-wide assessment of research quality in UK higher education institutions – REF2014 –Dundee was ranked the top University in Biological Sciences. More recent rankings widely recognized as indicators of scientific excellence place Dundee high in their rankings. The 2017 QS World University Rankings in Biological Sciences place Dundee 5th in the UK, 8th in Europe and 39th in the World as judged by ‘citations-per-paper’, one of the most widely recognized metrics of scientific excellence. This year’s ‘The State of Innovation’ report by Clarivate Analytics ranks Dundee as the most influential scientific research institution in the world for pharmaceuticals for the period 2006-16. The School enjoys a reputation as one of the most dynamic international centres for molecular cell biology, with outstanding laboratory and technology facilities.

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Nucleic Acid Structure Group 2008

Lilley, D.M.J. (2008) DNA Junctions and their Interaction with Resolving Enzymes In Protein-Nucleic Acid Interactions: Structural Biology [Eds Rice, P.A. and Correll, C.C.] RSC publications, 129-149.

Déclais, A.C., and Lilley, D.M.J. (2008) New insight into the recognition of branched DNA structure by junction-resolving enzymes Curr. Opin. Struct. Biol. 18, 86-95.

Lilley, D.M.J. (2008) Four-way helical junctions in DNA molecules in Mathematics of DNA Structure, Function, and Interactions. IMA In press.

Nucleic Acid Structure Group 2011

Aranda-Orgilles, B., Rutschow, D., Zeller, R., Karagiannidis, A. I., Kohler, A., Chen, C., Wilson, T., Krause, S., Roepcke, S., Lilley, D., Schneider, R. and Schweiger, S. (2011) Protein Phosphatase 2A (PP2A)-specific Ubiquitin Ligase MID1 Is a Sequence-dependent Regulator of Translation Efficiency Controlling 3-Phosphoinositide-dependent Protein Kinase-1 (PDPK-1). The Journal of biological chemistry. 286, 39945-39957
doi. 10.1074/jbc.M111.224451
Pubmed. 21930711

Nucleic Acid Structure Group 2009

Araki, L., Morita, K., Yamaguchi, M., Zhao, Z. Y., Wilson, T. J., Lilley, D. M. J. and Harusawa, S. (2009) Synthesis of Novel C4-Linked C-2-Imidazole Ribonucleoside Phosphoramidite and Its Application to Probing the Catalytic Mechanism of a Ribozyme. Journal of Organic Chemistry. 74, 2350-2356

Lilley, D. M. J. (2009) Comparative gel electrophoresis analysis of helical junctions in RNA. Methods in Enzymology, Vol 469: Biophysical, Chemical, and Functional Probes of Rna Structure, Interactions and Folding, Pt B. 469, 143-157

Molecular Microbiology 2008

Karnchanatat, A., Petsom, A., Sangvanich, P., Piapukiew, J., Whalley, A.J.S., Reynolds, C.D., Gadd, G.M., and Sihanonth, P. (2008) A novel thermostable endoglucanase from the wood-decaying fungus Daldinia eschscholzii (Ehrenb.:Fr.) Rehm. Enzyme and Microbial Technology 42, 404–413.

Fomina, M., Charnock, J.M., Hillier, S., Alvarez, R., Francis Livens, F., and Gadd, G.M. (2008) Role of fungi in the biogeochemical fate of depleted uranium. Current Biology 18, R375-R377.

Molecular Microbiology 2009

Andrell, J., Hicks, M. G., Palmer, T., Carpenter, E. P., Iwata, S. and Maher, M. J. (2009) Crystal Structure of the Acid-Induced Arginine Decarboxylase from Escherichia coli: Reversible Decamer Assembly Controls Enzyme Activity. Biochemistry. 48, 3915-3927

Coulthurst, S. J. and Sargent, F. (2009) Chaperone-signal peptide interactions on the Tat protein transport pathway. Febs Journal. 276, 3-3

Molecular Microbiology 2010

Ahmed, R. Z., Gadd, G. M. and Ahmed, N. (2010) Isolation of two Kocuria species capable of growing on various polycyclic aromatic hydrocarbons. African Journal of Biotechnology, 9, 3611-3617.

Borodkin, V. S. and van Aalten, D. M. (2010) An efficient and versatile synthesis of GlcNAcstatins-potent and selective O-GlcNAcase inhibitors built on the tetrahydroimidazo[1,2-a]pyridine scaffold. Tetrahedron, 66, 7838-7849.

Molecular Microbiology 2012

Bragonzi, A., Farulla, I., Paroni, M., Twomey, K. B., Pirone, L., Lore, N. I., Bianconi, I., Dalmastri, C., Ryan, R. P. and Bevivino, A. (2012) Modelling co-infection of the cystic fibrosis lung by Pseudomonas aeruginosa and Burkholderia cenocepacia reveals influences on biofilm formation and host response. Plos One. 7, e52330
d.o.i: 10.1371/journal.pone.0052330
PubMed: 3528780
PMC: 23284990

MRC Protein Phosphorylation Unit 2008

Al-Hakim, A. K., Zagorska, A., Chapman, L., Deak, M., Peggie, M. and Alessi, D. R. (2008) Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains. Biochem J. 411, 249-260

Ananieva, O., Darragh, J., Johansen, C., Carr, J. M., McIlrath, J., Park, J. M., Wingate, A., Monk, C. E., Toth, R., Santos, S. G., Iversen, L. and Arthur, J. S. (2008) The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling. Nat Immunol. 9, 1028-1036

MRC Protein Phosphorylation Unit 2009

Akue-Gedu, R., Rossignol, E., Azzaro, S., Knapp, S., Filippakopoulos, P., Bullock, A. N., Bain, J., Cohen, P., Prudhomme, M., Anizon, F. and Moreau, P. (2009) Synthesis, kinase inhibitory potencies, and in vitro antiproliferative evaluation of new Pim kinase inhibitors. J Med Chem. 52, 6369-6381

Alessi, D. R., Pearce, L. R. and Garcia-Martinez, J. M. (2009) New insights into mTOR signaling: mTORC2 and beyond. Sci Signal. 2, pe27

Arthur, J. S. and McGuire, V. A. (2009) Gene-targeting vectors. Methods Mol Biol. 561, 127-144