University of Dundee

The University of Dundee is one of the leading universities in Europe for research in Life Sciences. The 2016 QS World University Rankings in Biological Sciences place Dundee 5th in the UK and 40th in the world as judged by ‘citations-per-paper’, one of the most widely recognized metrics of scientific excellence. The School enjoys a reputation as one of the most dynamic international centres for molecular cell biology, with outstanding laboratory and technology facilities.

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MRC Protein Phosphorylation Unit 2008

Al-Hakim, A. K., Zagorska, A., Chapman, L., Deak, M., Peggie, M. and Alessi, D. R. (2008) Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains. Biochem J. 411, 249-260

Ananieva, O., Darragh, J., Johansen, C., Carr, J. M., McIlrath, J., Park, J. M., Wingate, A., Monk, C. E., Toth, R., Santos, S. G., Iversen, L. and Arthur, J. S. (2008) The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling. Nat Immunol. 9, 1028-1036

MRC Protein Phosphorylation Unit 2009

Akue-Gedu, R., Rossignol, E., Azzaro, S., Knapp, S., Filippakopoulos, P., Bullock, A. N., Bain, J., Cohen, P., Prudhomme, M., Anizon, F. and Moreau, P. (2009) Synthesis, kinase inhibitory potencies, and in vitro antiproliferative evaluation of new Pim kinase inhibitors. J Med Chem. 52, 6369-6381

Alessi, D. R., Pearce, L. R. and Garcia-Martinez, J. M. (2009) New insights into mTOR signaling: mTORC2 and beyond. Sci Signal. 2, pe27

Arthur, J. S. and McGuire, V. A. (2009) Gene-targeting vectors. Methods Mol Biol. 561, 127-144

MRC Protein Phosphorylation Unit 2010

Akue-Gedu, R., Nauton, L., Thery, V., Bain, J., Cohen, P., Anizon, F. and Moreau, P. (2010) Synthesis, Pim kinase inhibitory potencies and in vitro antiproliferative activities of diversely substituted pyrrolo[2,3-a]carbazoles. Bioorg Med Chem, 18, 6865-6873.

Blomster, H. A., Imanishi, S. Y., Siimes, J., Kastu, J., Morrice, N. A., Eriksson, J. E. and Sistonen, L. (2010) In vivo identification of sumoylation sites by a signature tag and cysteine-targeted affinity purification. J Biol Chem, 285, 19324-19329.

MRC Protein Phosphorylation Unit 2012

Al-Salihi, M. A., Herhaus, L. and Sapkota, G. P. (2012) Regulation of the transforming growth factor beta pathway by reversible ubiquitylation. Open Biol. 2, 120082
doi. 10.1098/rsob.120082
Pubmed. 22724073

Appleyard, M. V., Murray, K. E., Coates, P. J., Wullschleger, S., Bray, S. E., Kernohan, N. M., Fleming, S., Alessi, D. R. and Thompson, A. M. (2012) Phenformin as prophylaxis and therapy in breast cancer xenografts. Br J Cancer. 106, 1117-1122
doi. 10.1038/bjc.2012.56
Pubmed. 22361631

Gene Regulation and Expression 2008

Agostinho, M., Santos, V., Ferreira, F., Costa, R., Cardoso, J., Pinheiro, I., Rino, J., Jaffray, E., Hay, R. T. and Ferreira, J. (2008) Conjugation of human topoisomerase 2 alpha with small ubiquitin-like modifiers 2/3 in response to topoisomerase inhibitors: cell cycle stage and chromosome domain specificity. Cancer research. 68, 2409-2418
doi: 10.1158/0008-5472.CAN-07-2092
Pubmed:

Gene Regulation and Expression 2009

Ahel, D., Horejsi, Z., Wiechens, N., Polo, S. E., Garcia-Wilson, E., Ahel, I., Flynn, H., Skehel, M., West, S. C., Jackson, S. P., Owen-Hughes, T. and Boulton, S. J. (2009) Poly(ADP-ribose)-Dependent Regulation of DNA Repair by the Chromatin Remodeling Enzyme ALC1. Science. 325, 1240-1243

Ahmad, Y., Boisvert, F. M., Gregor, P., Cobley, A. and Lamond, A. I. (2009) NOPdb: Nucleolar Proteome Database-2008 update. Nucleic Acids Research. 37, D181-D184

Gene Regulation and Expression 2010

Awad, S., Ryan, D., Prochasson, P., Owen-Hughes, T. and Hassan, A. H. (2010) The Snf2 Homolog Fun30 Acts as a Homodimeric ATP-dependent Chromatin-remodeling Enzyme. Journal of Biological Chemistry, 285, 9477-9484.

Bailly, A. P., Freeman, A., Hall, J., Declais, A.-C., Alpi, A., Lilley, D. M. J., Ahmed, S. and Gartner, A. (2010) The Caenorhabditis elegans Homolog of Gen1/Yen1 Resolvases Links DNA Damage Signaling to DNA Double-Strand Break Repair. PLoS Genet, 6, e1001025.

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